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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit April 29, 2015

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SLAS ELN Reports: Biologics Come of Age — Therapeutic Antibody Discovery and Development
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Rob Howes of MedImmune and Joseph G. McGivern of Amgen offer a snapshot of the JBS April 2015 Special Issue on Therapeutic Antibody Discovery and Development in a new SLAS Electronic Laboratory Neighborhood e-zine feature article.

They also discuss the enriching experience of serving as the special issue's guest editors, a role they accepted to further fuel their interest and grow their expertise in the expanding field of biologics in drug discovery.
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SLAS Requests Input on Open Access Publishing
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SLAS is interested in your opinions regarding open access publishing of scientific journals.

Take 5-7 minutes (really, that's all!) to complete this short multiple choice survey and you could win a full registration to SLAS2016 (Jan. 23-27, 2016, in San Diego, CA) or one of 10 of the popular SLAS "Element of Surprise" T-shirts.

The survey is open today through May 15.
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SLAS Accepting SLAS2016 Tony B. Academic Travel Award Applications
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Tony B. awardees receive airfare, full conference registration, hotel accommodations and the opportunity to participate fully in SLAS2016, Jan. 23-27 in San Diego, CA.

Students, graduate students, post-doctoral associates and junior faculty may apply for this prestigious travel award by submitting a podium or poster abstract. Podium abstracts are due Aug. 3 and poster abstracts can be submitted as late as Sept. 21.
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New at JALA Online: Direct Nuclear Delivery of DNA by Photothermal Nanoblade
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In this technology brief, a UCLA team demonstrates direct nuclear delivery of DNA into live mammalian cells using the photothermal nanoblade.

Pulsed laser-triggered cavitation bubbles on a titanium-coated micropipette tip punctured both cellular plasma and nuclear membranes, which was followed by pressure-controlled delivery of DNA into the nucleus.

High-level and efficient plasmid expression in different cell types with maintained cell viability was achieved. SLAS Laboratory Automation Section members and JALA subscribers can access this brief now.
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Working with a FIRST Team? Apply for SLAS Grant
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Tyler Aldredge, Elliot Hui, Jody Keck and David Pechter are SLAS members who have received SLAS FIRST Team Grants to guide local For Inspiration and Recognition of Science and Technology (FIRST) teams.

FIRST is a nationwide program that engages young people in mentor-based programs that tackle long-term technology projects such as building robots to enter in local, regional and national competitions. Aldredge, Hui, Keck and Pechter agree that while modeling what a laboratory science and technology career offers is one reason to work with FIRST kids, encouraging curiosity, offering team-building skills and mentoring discipline is important to all students no matter where their interests lead them.
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Now at JBS Online: A Data Analysis Pipeline Accounting for Artifacts in Tox21 Quantitative HTS Assays
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SLAS Biomolecular Sciences Section members and JBS subscribers can read more about a data analysis pipeline that includes an updated signal noise–filtering/curation protocol and an assay interference flagging system.

Scientists from the National Institute of Environmental Health Sciences, MultiCASE and the National Center for Advancing Translational Sciences collaborated on this work.
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SAGE Publications Honored with 2015 International Academic and Professional Publisher Award
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SLAS's publishing partner for the Journal of Biomolecular Screening (JBS) and Journal of Laboratory Automation (JALA) was honored with the 2015 International Academic and Professional Publisher Award at the London Book Fair (LBF) International Excellence Awards on April 16. The LBF hosts 25,000+ professionals from 100+ countries each spring. More

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Scientists Develop First Liquid Nanolaser
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Scientists have developed the first liquid nanoscale laser. And it's tunable in real time, meaning you can quickly and simply produce different colors, a unique and useful feature. The laser technology could lead to practical applications, such as a new form of a "lab on a chip" for medical diagnostics. In addition to changing color in real time, the liquid nanolaser has additional advantages: it is simple to make, inexpensive to produce and operates at room temperature. More

Colorimetric Nanoplasmonic Assay To Determine Purity and Titrate Extracellular Vesicles
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Extracellular Vesicles — cell secreted vesicles that carry rich molecular information of the parental cell and constitute an important mode of intercellular communication — are becoming a primary topic in translational medicine. EVs (that comprise exosomes and microvesicles/microparticles) have a size ranging from 40 nm to 1 μm and share several physicochemical proprieties, including size, density, surface charge, and light interaction, with other nano-objects present in body fluids, such as single and aggregated proteins. More

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Congress Sends Energy Efficiency Bill to White House for President's Signature
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The House of Representatives gave final approval to a bill to boost energy efficiency, sending the measure to the White House after a marathon three-year push by the chemical industry and other advocates. President Barack Obama is expected to sign the legislation into law. The bill, S. 535, which was approved by the Senate last month, includes incentives to cut energy use in federal, commercial, manufacturing, school and residential buildings. More

Scientists Buzzing with Excitement after Bumblebee Genome Sequenced
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With spring in the air across most of North America, it wouldn't be difficult to notice the vibrantly colored flora that has begun to bloom all around. It's hard to imagine a pastoral setting without catching a glimpse of plump furry bumblebees lumbering from one flower to the next, but with declining population numbers across several species that scenario could become a reality — with devastating consequences to many ecosystems. More



Key Blood Pressure Drug Seen in Startling New Detail
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A new Arizona State University research study has revealed the fine details of how an experimental drug works to regulate blood pressure, paving the way to the development of better drugs. The ASU team's interdisciplinary work, led by Petra Fromme of the Biodesign Institute, may one day help scientists better control blood pressure irregularities with a new class of drugs that could limit harmful side effects. More

Electric Field Breakdown in Single Molecule Junctions
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Here we study the stability and rupture of molecular junctions under high voltage bias at the single molecule/single bond level using the scanning tunneling microscope-based break-junction technique. We synthesize carbon-, silicon- and germanium-based molecular wires terminated by aurophilic linker groups and study how the molecular backbone and linker group affect the probability of voltage-induced junction rupture. More

First Human Embryos Genetically Modified — More Will Come
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The prospect of genetically engineering humans has come a step closer, with the publication of the first paper to describe efforts to modify embryos. There is a long way to go before we can safely tinker with our genes, but at least one group in the U.S. and four in China are aiming to edit human embryos: this will be the first of many studies. The work was done using a gene editing technique called CRISPR (pronounced "crisper"). More

An End to Cancer Pain?
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A new study led by Dr. David Lam has discovered the trigger behind the most severe forms of cancer pain. Released in top journal Pain this month, the study points to TMPRSS2 as the culprit: a gene that is also responsible for some of the most aggressive forms of androgen-fueled cancers. Head of Oral and Maxillofacial Surgery at the Faculty of Dentistry, Lam's research initially focused on cancers of the head and neck, which affect more than 550,000 people worldwide each year. More

Career


Application Scientist
Andrew Alliance
Switzerland – Geneva area

Sr. Scientist – High-Content Imaging and Screening
Janssen Pharmaceuticals Companies of Johnson & Johnson
US – CA – San Diego

Research Scholar: Postdoctoral Position Temperature & Pressure Sensitive Paints
National Institute of Aerospace
US – VA – Hampton

More jobs at SLAS Career Connections


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