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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit April 30, 2014    SLAS2015    Moving? New job? Let SLAS know.    




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Expert Advice/Stimulating Conversation

Discussions and musings focused on the engaging field of laboratory science and technology.




May 13 SLAS Webinar: Cellular Protein-Protein Interaction Assays Implemented using BacMam
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Mary Ellen Digan, Ph.D., Novartis Institutes for Biomedical Research, provides an overview of cellular protein-protein interaction methods, highlights the strengths and weaknesses of various assay classes and shares specific examples from her work at Novartis in the May 13 SLAS Webinar.

"It is an exciting time not only for the understanding of basic biology but also for high-throughput screening where people are starting to move toward more complex cellular models," she offers. "Our understanding of all the previous years of work has built to where we're now able to work in a more complex world."

This SLAS Webinar is free to dues-paid SLAS members. Register today.


SLAS ELN Reports: Settling a New Biotech Frontier
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SLAS members Anne Marie Quinn and Thomas Hughes carved a place for their company, Montana Molecular, far from the biotech hubs that launched their careers.

Montana Molecular spent the past year making headlines with its genetically encoded fluorescent biosensors and probes for cell-based assays and live cell imaging, which help drug discovery scientists to observe and measure cell-signaling processes.

Read more in the SLAS Electronic Laboratory Neighborhood.

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Tony B. Academic Travel Awards Program Now Accepting Applications
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Airfare, SLAS2015 conference registration and hotel accommodations are provided to recipients of this valuable award for early career scientists.

"Presenting my research at the conference exposed me to feedback from industry scientists and engineers that I wouldn't have otherwise received," explains Timothy Ruckh, Ph.D., a postdoctoral research associate at Northeastern University and one of 46 SLAS2014 Tony B winners. "The experience has recalibrated how I view my own research."

July 28 is the due date for proposed podium presentations. Poster abstracts may be submitted until September 22.


SLAS Europe Council Unveils Plans
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SLAS Europe Chair Steve Rees shares highlights of the newly formed SLAS Europe Council to increase engagement throughout the SLAS community in Europe.

"To grow the presence of the Society in Europe, plans are being developed to collaborate with universities and other scientific societies to host or participate in a series of one- to two-day events across Europe," he says. "These will each be small events, targeted at a local audience, in which SLAS will bring its expertise to multiple regions within Europe."

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SLAS Beijing Seminar: Introduction to Lab Automation a Success!
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Four speakers addressed 50-plus participants on April 23 in Beijing at this SLAS Seminar, organized jointly with the Institute of Microbiology Chinese Academy of Sciences.

Bing Xie, Cisbio Bioassays; Anthony Partridge, Pharmaron; Lixin Zhang, Chinese Academy of Sciences; and Shuyi Si, Chinese Academy of Medical Sciences, presented laboratory automation applications in centralized and automated compound management systems, high-throughput screening (HTS) natural products and the progress of HTS for novel drugs in China.

See photos on Facebook and contact Kitty Yang for information on future SLAS Asia events.

Exclusive EndNote Discount for SLAS Members
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Collect. Collaborate. Create. From Anywhere!

EndNote is regarded as the industry standard software tool for publishing and managing bibliographies, citations and references. JBS SAGEtrack and JALA SAGEtrack users know the EndNote Fast Pass submission shortcut saves them time and effort by automatically populating many of the required fields.

For a limited time, SLAS dues-paid members can purchase Endnote X7 for the deeply discounted price of $95.45 (retail price: $249.95).

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Breakthrough: Human Neural Stem Cells Become Neurons in Monkey Brains
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A team of scientists based in Korea and Canada who transplanted human neural stem cells into the brains of nonhuman primates report that the hNSCs had differentiated into neurons at 24 months and did not cause tumors. The study is scheduled to be published in Cell Transplantation. The hNSCs were labeled with magnetic nanoparticles to enable them to be followed by magnetic resonance imaging. More

Multifunctional Nanoworms and Nanorods through a One-Step Aqueous Dispersion Polymerization
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Producing synthetic soft worm and rod structures with multiple chemical functionalities on the surface would provide potential utility in drug delivery, nanoreactors, tissue engineering, diagnostics, rheology modifiers, enzyme mimics, and many other applications. Here, we have synthesized multifunctional worms and rods directly in water using a one-step reversible addition–fragmentation chain transfer (RAFT)-mediated dispersion polymerization at high weight fractions of polymer (>10 wt %). More


Cancer Researchers Can Create Live Tumors With 3-D Printer
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Drexel’s Wei Sun, Albert Soffa chair professor in the College of Engineering, has devised a method for 3-D printing tumors that could soon be taking cancer research out of the petri dish. Using a mixture of cervical cancer cells and a hydrogel substance that resembles an ointment balm, Sun can print out a tumor model that can be used for studying their growth and response to treatment. More

World-to-Digital-Microfluidic Interface Enabling Extraction and Purification of RNA from Human Whole Blood
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Digital microfluidics is a powerful technique for simple and precise manipulation of microscale droplets of fluid. This technique enables processing and analysis of a wide variety of samples and reagents and has proven useful in a broad range of chemical, biological, and medical applications. Handling of "real-world" samples has been a challenge, however, because typically their volumes are greater than those easily accommodated by DMF devices and contain analytes of interest at low concentration. More

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Novel Therapies for Neuroprotection in Stroke
By Dr. Afsaneh Motamed-Khorasani    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Stroke is the second-leading cause of death worldwide, according to the World Health Organization. There is considerable interest in investigating novel treatments for neuroprotection during stroke, but at present no approved treatment is available for pathological processes occurring in the brain during stroke. Minocycline, cerebrolysin, Ginsenoside-Rd, G-CSF, NA-1 and albumin are some of the drugs being researched. However, treatment methods that showed significant promise in animal models of stroke have not been successful in human trials. More

Automation: The Answer to Tedious Manual Sample Preparation for Mass Spectrometry?
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Mass spectrometry technology has advanced extremely rapidly over the last decade, with MS techniques now being widely used in life science research, and even finding their way into the clinical setting for diagnostic applications. As one of the first sectors to adopt MS technology, the drug discovery market has been at the forefront of this revolution and, as such, has now become one of the first areas of research to run up against the major limitation of the technique — sample preparation. More

Pair of Catalysts Builds Chiral Rings Using Visible Light
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
By combining two catalysts, researchers have used photochemistry to build enantiomerically enriched rings in high yields. The advance could add to the tool kit for building motifs present in agrochemicals and pharmaceuticals. For more than a century, chemists have talked about generating chirality with photochemistry because it can access products not available by other routes. More

New Method to Analyze How Cancer Cells Die    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A team from The University of Manchester — part of the Manchester Cancer Research Centre — have found a new method to more efficiently manufacture a chemical used to monitor cancer cells. The technique could lead to clearer and better quality images on PET scans. The number of cells within tissue is controlled through apoptosis — a process where cells shrink and their components break up, also known as programmed cell death. More

Protein That Shrinks Depressed Brains Identified
New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Could preventing the brain shrinkage associated with depression be as simple as blocking a protein? Post-mortem analysis of brain tissue has shown that the dendrites that relay messages between neurons are more shrivelled in people with severe depression than in people without the condition. This atrophy could be behind some of the symptoms of depression, such as the inability to feel pleasure. As a result, drugs that help repair the neuronal connections, like ketamine, are under investigation. More

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