This message contains images. If you don't see images, click here to view.
Advertise in this news brief.


Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit May 07, 2014    SLAS2015    Moving? New job? Let SLAS know.    




Providing clean, uninterrupted electrical power.

Certified UPS’s to protect your laboratory’s critical instrumentation and resolve current and potential power issues.


Manufacturing for Chemists since 1928

Laboratory & Custom Reagents ISO 17025 Accredited Certificate #3336.01 Custom Packaging Configurations Order Today 800-858-9682




SLAS ELN Reports: 3D Printing in the Lab —
Facilitating Innovation, Fueling Visions

SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Two researchers who are working on projects with implications for different aspects of drug discovery reveal their motivations for using 3D printing in the laboratory in the SLAS Electronic Laboratory Neighborhood e-zine.

Jordan Miller and Lee Cronin are inspired not only by the challenge of doing innovative science, but also by the opportunity to make their work accessible to scientists around the world.


NEW at JBS Online: Integrating High-Content Analysis into a Multiplexed Screening Approach to Identify and Characterize GPCR Agonists
SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A collaborative team, including 2013 SLAS Innovation Award winner Andrea Weston of Bristol-Myers Squibb, published this work last week.

"The results presented here demonstrate that once a clear understanding of the desired pharmacological fingerprint for a given GPCR has been established, a multiassay approach provides a powerful means to identify, characterize, and optimize GPCR-targeted compounds," from the manuscript discussion section. "Our findings also underscore the advantages of using high-content imaging to uncover compound-induced changes to typical cellular physiology. Combining a multiassay platform, high-content imaging assays, and more up-front studies to understand the mechanistic basis for efficacy will greatly improve efforts to design safer and more efficacious therapeutics."

Sponsored Content

New at JALA and JBS SAGEtrack: ORCID Interface
SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
To provide even better service and support to JALA and JBS authors, the SAGEtrack online manuscript submission system now interacts with ORCID (Open Researcher and Contributor ID). ORCID allows researchers to create permanent, unique ORCID records that may be linked to contact information, institutional affiliations, publication records and other identifiers. JALA and JBS SAGEtrack now give authors the ability to use and directly access their ORCID IDs. More

Sponsored Content

May 13 SLAS Webinar: Cellular Protein-Protein Interaction Assays Implemented using BacMam
SLAS     Share    Share on FacebookTwitterShare on LinkedinE-mail article
There is still time to register for this SLAS Webinar to be presented by Mary Ellen Digan, Ph.D., of Novartis Institutes for Biomedical Research.

She will provide an overview of cellular protein-protein interaction methods, the strengths and weaknesses of various assay classes and examples of BRET assays using BacMam vectors.

This SLAS Webinar is free to dues-paid SLAS members.

Ligand-receptor capture(LRC-TriCEPS/CaptiRec)
Identifies on living cells the receptors of your orphan ligand (Peptide/Protein/Antibody/Virus) using a tri-functional linker in a LC-MS/MS based system.
Advanced rotary & linear motion sensors
Renishaw | RLS
Reliable, low cost, rotary and linear magnetic encoders designed for motor feedback solutions in harsh environments.

Laurie Garrett Provides Insight to 2014 Ebola Outbreak
SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
SLAS2015 keynote speaker Laurie Garrett appeared on CNN in April to explain the difficulties of containing the 2014 Ebola outbreak.

"The number one challenge," she says in the video, is that the outbreak is in different countries involving different governments. She cites the good work being done to contain its spread.

Garrett, following Ebola as senior fellow for global health at the Council on Foreign Relations, is an SLAS2015 keynote speaker on Feb. 11.

Why Should You Attend SLAS2015?
SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A new video posted to provides the reasons! Take a look and see why you will want to mark Feb. 7-11 on your calendar for the Fourth Annual Conference and Exhibition, Come Transform Research, Washington, D.C.

The SLAS2015 Headquarters Hotel, the Marriott Marquis, opened last week to rave reviews. See photos here.

Unlimited Modes of Detection = 1 Microplate Reader
With an industry-leading number of detection modes, SpectraMax i3 not only meets your application needs today, it also adapts to your changing requirements tomorrow. Read about the latest microplate reader applications like StainFree Cell Detection and ScanLater Western Blot in the Novel Microplate Reader Applications eBook. Download here >>
Cloud Solutions Designed with Scientists in Mind
  • Save time and money with
       Acquire™ lab supplies
       management software.
  • Streamline compound
       management with Store™
  • Make internal and external
       compounds and assays
       accessible to all project
       teams with Request™
  • Visualize™ enables
       securely sharing compound
       and biological assay results.
  • Advertisement
    Real-Time Monitoring Cardiomyocyte Beating
    The xCELLigence RTCA Cardio System monitors cardiomyocyte beating functions in a 96-well format under physiological conditions, using a noninvasive label-free impedance-based technology. Rule out both acute and long-term cardiotoxicity in a single experiment. For more information, please visit


    Nanoengineers Develop Basis for Electronics That Stretch at Molecular Level
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Nanoengineers are asking what might be possible if semiconductor materials were flexible and stretchable without sacrificing electronic function? Today's flexible electronics are already enabling a new generation of wearable sensors and other mobile electronic devices. But these flexible electronics, in which very thin semiconductor materials are applied to a thin, flexible substrate in wavy patterns and then applied to a deformable surface such as skin or fabric, are still built around hard composite materials that limit their elasticity. More

    AstraZeneca Rejects New Pfizer Offer
    BBC    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    U.K. drugs firm AstraZeneca has rejected the new takeover offer from Pfizer. The U.S. company had earlier raised the price it was offering for AstraZeneca to the equivalent of £50 a share, valuing the firm at £63 billion. But Astra said the new terms offered were, "inadequate, substantially undervalue AstraZeneca and are not a basis on which to engage with Pfizer." More


    Supercritical Fluid Chromatography Seeks New Users
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Supercritical fluid chromatography, or SFC, has been around for decades. During that time, the separation technique has fallen in and out of and back in favor. But it has consistently been relegated to niche status. Could that finally be changing? Instrument manufacturers certainly hope so. In the past several years, instrument companies Agilent Technologies and Waters Corp. have both brought out new analytical SFC instruments. More

    Out of Africa: Special Report on Point-of-Care Diagnostics
    Drug Discovery News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Sitting at a table in a makeshift clinic several miles outside of Apesika, Ghana, HIV patient Bekoe Mahama leans forward to spit onto a small strip of paper handed him by a clinician. The doctor asks him how the antiretroviral therapy (ART) has been treating him and if he needs any other assistance. Glancing at the paper strip, the doctor smiles. Bekoe is showing no signs of liver damage. He can continue his ART. More

    Predict toxicity earlier!

    Eliminate cardiotoxic compounds and identify potential cardiac drug candidates earlier in the
                                      drug discovery process.
    Microfluidics and Miniaturization Made Easy

    Microfabrication and Design Services for Custom and OEM Devices. Let our 40+ years’ experience in photomask fabrication work for you.
    To learn more click here

    Solving 3D Genomics Puzzles Holds Key to Understanding Human Diseases
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Scientists at McGill University say they have discovered that the 3D shape of a leukemia cell's genome holds a key to solving the puzzle of human diseases. The researchers report their findings in Genome Biology. Josée Dostie, Ph.D., a researcher in the faculty of medicine in the department of biochemistry, focused on the shape made by the region spanning the Homeobox A genes in human cells, a set of 11 genes encoding proteins that are highly relevant to numerous types of cancers. More

    Molecular Rotors As Conditionally Fluorescent Labels for Rapid Detection of Biomolecular Interactions
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    We demonstrate the use of fluorescent molecular rotors as probes for detecting biomolecular interactions, specifically peptide–protein interactions. Molecular rotors undergo twisted intramolecular charge transfer upon irradiation, relax via the nonradiative torsional relaxation pathway, and have been typically used as viscosity probes. More

    Extended-Nanofluidics: Fundamental Technologies, Unique Liquid Properties, and Application in Chemical and Bio Analysis Methods and Devices
    Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Engineering using liquids confined in channels 10−1000 nm in dimension, or "extended-nanofluidics," is the next target of microfluidic science. Liquid properties at this scale were unrevealed until recently because of the lack of fundamental technologies for investigating these ultrasmall spaces. In this article, the fundamental technologies are reviewed, and the emerging science and technology in the extended-nanospace are discussed. More

    Additive Stops Aging in Super Glassy Polymer Membranes    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Putting a stop to aging has now been made possible for highly porous polymer membranes whose efficiency in the separation of gases falls off fast when parts of their polymer chains rearrange, as so do their pores. In the journal Angewandte Chemie, a team of researchers has now introduced a method for preventing this relaxation of the polymer chains: special porous particles made of an aromatic framework incorporate the polymer chains and hold them in their original position. More

    Mapping Neural Activity with Molecular Precision
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Launched in 2013, the national BRAIN Initiative aims to revolutionize our understanding of cognition by mapping the activity of every neuron in the human brain, revealing how brain circuits interact to create memories, learn new skills, and interpret the world around us. Before that can happen, neuroscientists need new tools that will let them probe the brain more deeply and in greater detail, said Alan Jasanoff, an MIT associate professor of biological engineering. More

    Edgy Look at 2D Molybdenum Disulfide
    Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The drive to develop ultrasmall and ultrafast electronic devices using a single atomic layer of semiconductors, such as transition metal dichalcogenides, has received a significant boost. Researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have recorded the first observations of a strong nonlinear optical resonance along the edges of a single layer of molybdenum disulfide. More

    Compact High-Throughput Nucleic Acid Isolation
    The revolutionary compact chemagic 360 (80 x 65 x 90 cm L/W/H) purifies nucleic acids from 10 µl - 10 ml sample volume by managing 1 96 samples/run. An integrated dispenser for automated buffer filling, QA software and barcode reading allow unique flexibility in sample processing and throughput needs.
    SyncroPatch384 PE - Patch clamp goes HTS!
    The SyncroPatch 384 PE is a revolutionary platform for ion channel screening, fully compatible with HTS-standards. The SyncroPatch 384PE has the highest throughput on the market, enabling 768 parallel whole-cell, gigaseal recordings from ligand- and voltage-gated ion channels. Contact us today for a demo with your cells and compounds!
    Sample Screening from your Compound

    The comPOUND system comprises a high-density sample storage unit and an additional suite of specialized delivery and processing modules to enable easy integration into any compound management or screening system.


    Manager, Biological Sample Management
    US – PA – Collegeville

    Staff Quality Assurance Engineer
    US – MI – Southfield

    Software Developer
    Hudson Robotics
    US – NJ – Springfield


    SLAS Point-to-Point
    Colby Horton, Vice President of Publishing, 469.420.2601
    Download media kit

    Dennis Hall, Senior Content Editor, 469.420.2656   
    Contribute news

    This edition of SLAS Point-to-Point was sent to ##Email##. To unsubscribe from receiving SLAS Point-to-Point, click here. To unsubscribe from all SLAS e-mail communications, please click here. Did someone forward this edition to you? Subscribe here — it's free!

    SLAS Terms of Use Policy
    Recent issues

    April 30, 2014
    April 23, 2014
    April 16, 2014
    April 9, 2014

    7701 Las Colinas Ridge, Ste. 800, Irving, TX 75063