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SLAS ELN Reports: 3D Printing in the Lab —
Facilitating Innovation, Fueling Visions
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Two researchers who are working on projects with implications for different aspects of drug discovery reveal their motivations for using 3D printing in the laboratory in the SLAS Electronic Laboratory Neighborhood e-zine.
Jordan Miller and Lee Cronin are inspired not only by the challenge of doing innovative science, but also by the opportunity to make their work accessible to scientists around the world.
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NEW at JBS Online: Integrating High-Content Analysis into a Multiplexed Screening Approach to Identify and Characterize GPCR Agonists
SLAS Share
A collaborative team, including 2013 SLAS Innovation Award winner Andrea Weston of Bristol-Myers Squibb, published this work last week.
"The results presented here demonstrate that once a clear understanding of the desired pharmacological fingerprint for a given GPCR has been established, a multiassay approach provides a powerful means to identify, characterize, and optimize GPCR-targeted compounds," from the manuscript discussion section. "Our findings also underscore the advantages of using high-content imaging to uncover compound-induced changes to typical cellular physiology. Combining a multiassay platform, high-content imaging assays, and more up-front studies to understand the mechanistic basis for efficacy will greatly improve efforts to design safer and more efficacious therapeutics."
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New at JALA and JBS SAGEtrack: ORCID Interface
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To provide even better service and support to JALA and JBS authors, the SAGEtrack online manuscript submission system now interacts with ORCID (Open Researcher and Contributor ID). ORCID allows researchers to create permanent, unique ORCID records that may be linked to contact information, institutional affiliations, publication records and other identifiers. JALA and JBS SAGEtrack now give authors the ability to use and directly access their ORCID IDs.
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May 13 SLAS Webinar: Cellular Protein-Protein Interaction Assays Implemented using BacMam
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There is still time to register for this SLAS Webinar to be presented by Mary Ellen Digan, Ph.D., of Novartis Institutes for Biomedical Research.
She will provide an overview of cellular protein-protein interaction methods, the strengths and weaknesses of various assay classes and examples of BRET assays using BacMam vectors.
This SLAS Webinar is free to dues-paid SLAS members.
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Laurie Garrett Provides Insight to 2014 Ebola Outbreak
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SLAS2015 keynote speaker Laurie Garrett appeared on CNN in April to explain the difficulties of containing the 2014 Ebola outbreak.
"The number one challenge," she says in the video, is that the outbreak is in different countries involving different governments. She cites the good work being done to contain its spread.
Garrett, following Ebola as senior fellow for global health at the Council on Foreign Relations, is an SLAS2015 keynote speaker on Feb. 11.
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Why Should You Attend SLAS2015?
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A new video posted to SLAS2015.org provides the reasons! Take a look and see why you will want to mark Feb. 7-11 on your calendar for the Fourth Annual Conference and Exhibition, Come Transform Research, Washington, D.C.
The SLAS2015 Headquarters Hotel, the Marriott Marquis, opened last week to rave reviews. See photos here.
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Nanoengineers Develop Basis for Electronics That Stretch at Molecular Level
Science Daily Share
Nanoengineers are asking what might be possible if semiconductor materials were flexible and stretchable without sacrificing electronic function? Today's flexible electronics are already enabling a new generation of wearable sensors and other mobile electronic devices. But these flexible electronics, in which very thin semiconductor materials are applied to a thin, flexible substrate in wavy patterns and then applied to a deformable surface such as skin or fabric, are still built around hard composite materials that limit their elasticity.
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AstraZeneca Rejects New Pfizer Offer
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U.K. drugs firm AstraZeneca has rejected the new takeover offer from Pfizer. The U.S. company had earlier raised the price it was offering for AstraZeneca to the equivalent of £50 a share, valuing the firm at £63 billion. But Astra said the new terms offered were, "inadequate, substantially undervalue AstraZeneca and are not a basis on which to engage with Pfizer."
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Supercritical Fluid Chromatography Seeks New Users
Chemical & Engineering News Share
Supercritical fluid chromatography, or SFC, has been around for decades. During that time, the separation technique has fallen in and out of and back in favor. But it has consistently been relegated to niche status. Could that finally be changing? Instrument manufacturers certainly hope so. In the past several years, instrument companies Agilent Technologies and Waters Corp. have both brought out new analytical SFC instruments.
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Out of Africa: Special Report on Point-of-Care Diagnostics
Drug Discovery News Share
Sitting at a table in a makeshift clinic several miles outside of Apesika, Ghana, HIV patient Bekoe Mahama leans forward to spit onto a small strip of paper handed him by a clinician. The doctor asks him how the antiretroviral therapy (ART) has been treating him and if he needs any other assistance. Glancing at the paper strip, the doctor smiles. Bekoe is showing no signs of liver damage. He can continue his ART.
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Solving 3D Genomics Puzzles Holds Key to Understanding Human Diseases
Genetic Engineering & Biotechnology News Share
Scientists at McGill University say they have discovered that the 3D shape of a leukemia cell's genome holds a key to solving the puzzle of human diseases. The researchers report their findings in Genome Biology. Josée Dostie, Ph.D., a researcher in the faculty of medicine in the department of biochemistry, focused on the shape made by the region spanning the Homeobox A genes in human cells, a set of 11 genes encoding proteins that are highly relevant to numerous types of cancers.
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Molecular Rotors As Conditionally Fluorescent Labels for Rapid Detection of Biomolecular Interactions
Journal of the American Chemical Society Share
We demonstrate the use of fluorescent molecular rotors as probes for detecting biomolecular interactions, specifically peptide–protein interactions. Molecular rotors undergo twisted intramolecular charge transfer upon irradiation, relax via the nonradiative torsional relaxation pathway, and have been typically used as viscosity probes.
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Extended-Nanofluidics: Fundamental Technologies, Unique Liquid Properties, and Application in Chemical and Bio Analysis Methods and Devices
Analytical Chemistry Share
Engineering using liquids confined in channels 10−1000 nm in dimension, or "extended-nanofluidics," is the next target of microfluidic science. Liquid properties at this scale were unrevealed until recently because of the lack of fundamental technologies for investigating these ultrasmall spaces. In this article, the fundamental technologies are reviewed, and the emerging science and technology in the extended-nanospace are discussed.
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Additive Stops Aging in Super Glassy Polymer Membranes
Phys.org Share
Putting a stop to aging has now been made possible for highly porous polymer membranes whose efficiency in the separation of gases falls off fast when parts of their polymer chains rearrange, as so do their pores. In the journal Angewandte Chemie, a team of researchers has now introduced a method for preventing this relaxation of the polymer chains: special porous particles made of an aromatic framework incorporate the polymer chains and hold them in their original position.
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Mapping Neural Activity with Molecular Precision
Bioscience Technology Share
Launched in 2013, the national BRAIN Initiative aims to revolutionize our understanding of cognition by mapping the activity of every neuron in the human brain, revealing how brain circuits interact to create memories, learn new skills, and interpret the world around us. Before that can happen, neuroscientists need new tools that will let them probe the brain more deeply and in greater detail, said Alan Jasanoff, an MIT associate professor of biological engineering.
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Edgy Look at 2D Molybdenum Disulfide
Lab Manager Share
The drive to develop ultrasmall and ultrafast electronic devices using a single atomic layer of semiconductors, such as transition metal dichalcogenides, has received a significant boost. Researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have recorded the first observations of a strong nonlinear optical resonance along the edges of a single layer of molybdenum disulfide.
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SLAS Point-to-Point
Colby Horton, Vice President of Publishing, 469.420.2601
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