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Julea Vlassakis Earns SLAS Graduate Education Fellowship Grant
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Vlassakis is a bioengineering graduate student and Ph.D. candidate in the Herr Lab at the University of California, Berkeley.
The SLAS grant provides $100,000 over two years to help Vlassakis further her research on high-throughput quantitative electrophoretic separations of actin species from single cells. She believes accurate biomolecular screening of the effects of drug treatments on the distribution of actin will become a critical step in identification of novel therapies.
SLAS will begin accepting applications for the 2018 SLAS Graduate Education Fellowship Grant in the fall of 2017. You can read about last year's inaugural winner in the SLAS Electronic Laboratory Neighborhood e-zine.
May 18 SLAS Webinar: Modular, Fully Integrated or Collaborative Automation?
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The establishment of the AstraZeneca-Medical Research Council UK Centre for Lead Discovery led to revamping the company's screening infrastructure to embrace next generation high-throughput screening automation.
In this real-time SLAS Webinar taking place May 18, free to dues-paying SLAS members, AstraZeneca's Mark Wigglesworth recaps the organization's experience and reviews what works, what scientists like, what best conforms to the demands of the assay and summarizes project learnings regarding collaborative robotics, remote operation and unforeseen benefits.
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SLAS ELN Reports: SLAS2017 Student Poster Winners — Courageous Young Minds
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Undaunted by international travel or speaking before world-class professionals, forward-thinking student scientists Alice Bong, Sudip Mondal and Bilal Zulfiqar share how the SLAS Student Poster Award boosts self-confidence, builds connections to potential collaborators and advances life sciences research.
Bong is a Ph.D. candidate at the University of Queensland, Mondal a postdoctoral researcher at The University of Texas at Austin and Zulfiqar a Ph.D. student at Griffith Institute for Drug Discovery at Griffith University. Read more in the SLAS Electronic Laboratory Neighborhood e-zine.
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Vote Today! 2017 SLAS Discovery and SLAS Technology Art of Science Contest Voting Ends May 19
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Five finalists have been selected, and now it's up to the life sciences discovery and technology community to decide which one will receive the grand prize of a $500 USD Amazon gift card. Vote for your favorite finalist by 5 p.m. U.S. Eastern time on Friday, May 19.
The criteria are completely subjective — vote for the image you think is the coolest, prettiest, scariest, most interesting or whatever. In other words, vote for the one you personally like the best.
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2017 SLAS Europe High-Content Screening Conference Call for Abstracts
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SLAS invites research scientists, engineers, academics and business leaders to submit scientific abstracts for presentation at this Sept. 19-20 conference in Madrid, Spain. The conference has four focus areas: data analysis, screening, technology and model systems.
The podium abstract submission deadline is Monday, June 5; poster abstract submissions close on Aug. 21. Read about last year's SLAS Europe High-Content Screening Conference in the SLAS Electronic Laboratory Neighborhood e-zine and SLAS Discovery.
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Abstracts Due June 1 for SLAS Discovery and SLAS Technology Special Issues
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Special issues of SLAS Discovery and SLAS Technology are hallmarks of editorial excellence, popular with readers and highly cited. Manuscript proposals (abstracts) for original research reports, reviews, perspectives and technical notes/technology briefs are being accepted through June 1 for special issues on these important topics:
Enabling Technology in Cell-Based Therapies: Scale-Up, Scale-Out or Program In-Place
DNA-Encoded Chemical Library Technologies: Screening and Hit Identification
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Atlases of Immune Cells Surrounding Tumors May Guide Immunotherapy
Bioscience Technology Share
Two independent studies have begun mapping the connections between and identities of the thousands of immune cells surrounding human tumors. One research group, looking at kidney cancer, found that tumors with different clinical outcomes have unique immune cell profiles. These profiles can also estimate a cancer patient's prognosis. The other group, looking at lung cancer, showed that even early tumors have disturbed immune cell activity.
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Second-Ever ALS Drug Approved
The Scientist Share
The U.S. Food and Drug Administration approved edaravone (Radicava) for the treatment of amyotrophic lateral sclerosis (ALS). The drug, manufactured by MT Pharma America, the U.S. subsidiary of the Japanese company Mitsubishi Tanabe Pharma Corporation, is only the second approved ALS treatment in the U.S. The first, riluzole (Rilutek), was approved in December 1995.
"I'm very happy, frankly, that there is a second drug approved for ALS," said Neil Shneider, director of the Eleanor and Lou Gehrig ALS Center at Columbia University Medical Center.
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A Slingshot to Shoot Drugs Onto the Site of an Infection
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An international team of researchers from the University of Rome Tor Vergata and the University of Montreal has reported, in a paper published this week in Nature Communications, the design and synthesis of a nanoscale molecular slingshot made of DNA that is 20,000 times smaller than a human hair. This molecular slingshot could "shoot" and deliver drugs at precise locations in the human body once triggered by specific disease markers.
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Molecular Recognition within the Cavity of a Foldamer Helix Bundle: Encapsulation of Primary Alcohols in Aqueous Conditions
Journal of the American Chemical Society Share
Artificial synthetic molecules able to adopt well-defined stable secondary structures comparable to those found in nature ("foldamers") have considerable potential for use in a range of applications such as biomaterials, biorecognition, nanomachines and as therapeutic agents. The development of foldamers with the ability to bind and encapsulate "guest" molecules is of particular interest; as such an ability is a key step toward the development of artificial sensors, receptors and drug-delivery vectors.
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Antibiotic Resistance Charted on Interactive World Map
Genetic Engineering & Biotechnology News Share
With the rapid rise in antimicrobial drug resistance, having the ability to identify trends in antibiotic use and control antibiotic resistance on the global scale is an important step in halting and potentially reversing the spread of drug resistance. In 2014, the problem of drug resistance was named among serious threats to human health by the World Health Organization.
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Boosting NMR Sensitivity
Chemical & Engineering News Share
Poor sensitivity is one of the drawbacks of nuclear magnetic resonance spectroscopy. A method called dynamic nuclear polarization can improve the situation, particularly for solid-state NMR, by transferring spin polarization from unpaired electrons on paramagnetic agents to the nuclei of the molecules being analyzed. This aligns the nuclei and thus boosts the NMR signal. But the electron spins are such strong magnets that they interfere with the magnetization they just induced on the nuclei, causing the boosted signal to decay quickly and broadening the peaks in the resulting spectra.
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FIONA to Take on the Periodic Table's Heavyweights
Lab Manager Share
A new tool at the Department of Energy's Lawrence Berkeley National Laboratory will be taking on some of the periodic table's latest heavyweight champions to see how their masses measure up to predictions.
Dubbed FIONA, the device is designed to measure the mass numbers of individual atoms of superheavy elements, which have higher masses than uranium.
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New Math Techniques to Improve Computational Efficiency in Quantum Chemistry
Science Daily Share
Researchers at Sandia National Laboratories have developed new mathematical techniques to advance the study of molecules at the quantum level.
Mathematical and algorithmic developments along these lines are necessary for enabling the detailed study of complex hydrocarbon molecules that are relevant in engine combustion. Existing methods to approximate potential energy functions at the quantum scale need too much computer power and are thus limited to small molecules.
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Senior Clinical Research Coordinator
Science 37
US – CA – Playa Vista
Research Scientist High-Throughput Screening
Vertex
US – MA – Boston
Scientific Manager, Sample Management - Biomolecular Engineering Group
Genentech
US – CA – South San Francisco
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