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SLAS ELN Reports: New Tools to Rapidly Diagnose Infections and Detect Antibiotic-Resistant Bacteria
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 2016 SLAS Innovation Award winner Shana Kelley was a graduate student at Cal Tech when a basic science project serendipitously yielded a technique for identifying single nucleotide mismatches in DNA — i.e., disease-related mutations. "It just popped out of the basic science we were doing and I thought, 'hmmm, that's interesting ...'" she recalls.
Kelley went on to patent the approach and co-found GeneOhm Sciences, as well as running her own laboratory at the University of Toronto. Read more about the award winner and her work on diagnostic devices in the SLAS Electronic Laboratory Neighborhood e-zine.
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May 17 SLAS Webinar on Challenges of 1536-Well Cell-Based Screening
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Join SLAS and Helen Plant of AstraZeneca (U.K.) to explore the practical intricacies of doing small volume, 1536-well cell-based assays. "Successful conversion of complex phenotypic assays to 1536-well formats results in up to a 50 percent reduction in cell number requirements and approximately a four-fold reduction in time taken to perform a full HTS screening campaign," she says.
Plant explains how the BlueCatBio centrifugal plate washer integrates centrifugal emptying with the individual addition of up to four separate solutions for complex phenotypic assays. Dues-paying SLAS members may participate at no cost. SLAS Webinars are presented by JALA and JBS, the official SLAS journals.
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SLAS2017 Call for Scientific Podium Presentations
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Are you leveraging the power of new technologies to achieve scientific objectives? SLAS wants to hear from you. Submit a scientific presentation abstract by Aug. 8 for the opportunity to showcase your research on the global stage of SLAS2017, Feb. 4-8, Washington, DC.
Detailed information on seven scientific tracks, including overall descriptions, session titles and track and session chairs are now online. The SLAS2017 Scientific Program Committee is looking for innovation, relevance and applicability.
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New LabAutopedia Video: Activating the Immune System Against Cancer
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A new video explains how the immune system is activated against cancer cells and how cancer cells respond. It is just one way the collaborative life sciences discovery and technology community shares information and challenges one another on the SLAS scientific wiki.
Other new topics explored on LabAutopedia include lab-grown skin tissue, history of the U.S. war on cancer, gravitational waves and the German master inventor Artur Fischer.
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Protect Your Scholarly Identity
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 Register now with ORCID to secure a unique identifier for yourself so editors, funding agencies, publishers and institutions can reliably recognize you in the same way that ISBNs and DOIs identify books and articles. ORCID supports automated linkages between you and your professional activities to ensure your work is properly recognized.
Once you have an ORCID ID, be sure to add it to your JALA SAGEtrack and JBS SAGEtrack user profile. Registration is fast, free and easy.
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Since 1997 Rad Source Technologies has been the expert in providing renewable, non-isotope, ionizing radiation replacements for self-shielded gamma irradiators. Currently, there are over 300 renowned hospital, university, and pharmaceutical research institutions using Rad Source X-ray technology. To find out more about our equipment, select your application and you will find equipment specifications, literature references, white papers, training videos, discussion forums, as well as other helpful info.
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Digilab has combined advancements in the miniaturization of spectrometers, data storage, robotics & automation, to develop the Digilab Identity Raman Plate Reader, enabling fast sample measurement into microtiter plates or slides, with the flexibility of low-to-high throughput for many industry specific applications. Why settle for less with your research investment?
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The comPOUND system comprises a high-density sample storage unit and an additional suite of specialized delivery and processing modules to enable easy integration into any compound management or screening system.
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No Longer Lost in Translation: Biochemists Watch Gene Expression in Real Time
Phys.org Share
Most high school students can recite the central dogma of molecular biology: DNA makes RNA makes protein. We all know it. But have we ever seen it?
Parts of it, yes. DNA transcription, the first step in gene expression, has been quantified in real time. But the second step — the translation of genetic code into a protein — is much harder to see in living systems, and until now has eluded us.
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New Zika Diagnostic
The Scientist Share
Scientists have developed a cheap, rapid, paper-based diagnostic test for Zika virus. The test is capable of discriminating between Zika and related viruses like dengue, and can detect Zika even at low levels in plasma from infected monkeys, researchers from MIT and their colleagues reported in Cell.
Testing takes only two to three hours, which "is much faster and cheaper than the PCR tests used now," study coauthor James Collins, a bioengineer at MIT, told The New York Times.
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Squished Cells Could Shape Design of Synthetic Materials
Science Daily Share
All living cells are basically squishy balloons full of water, proteins and DNA, surrounded by oily membranes. Those membranes stand up to significant amounts of stretching and bending, but only recently have scientists started to fully appreciate the useful organization and functions that result from all that stress.
Inspired by this emerging understanding, a multidisciplinary group at the University of Wisconsin-Madison is trying to recreate aspects of those broad design principles in synthetic systems comprised of simple membranes and complex fluids.
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New Insights into Rare Cancer Uncovered in Large Genome Analysis Study
Genetic Engineering & Biotechnology News Share
Research teams from 39 institutions around the world collected and analyzed 91 samples of adrenocortical carcinoma — hoping to improve our understanding about one of the rarest, and lethal, types of cancer. This comprehensive analysis was performed as part of The Cancer Genome Atlas Research Network.
The investigators from this new study were able to identify several genes that drive adrenal cancer. Moreover, the analysis uncovered double the number of genetic drivers already known to fuel adrenal cancer.
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Gene Therapy Stops Rare Childhood Brain Disease
Science Magazine Share
Gene therapy is living up to its promise of halting a rare, deadly brain disease in young boys. In a new study presented in Washington, D.C., at the annual meeting of the American Society of Gene and Cell Therapy, all but one of 17 boys with adrenoleukodystrophy remained relatively healthy for up to two years after having an engineered virus deliver into their cells a gene to replenish a missing protein needed by the brain. The results, which expand on an earlier pilot study, bring this ALD therapy one step closer to the clinic.
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Call to Re-Examine '14-Day Rule' Limiting In Vitro Human-Embryo Research
Lab Manager Share
Bioethicists from Case Western Reserve University School of Medicine and The Hastings Center, working with a research administrator at The Rockefeller University, are proposing a reexamination of an internationally recognized rule limiting in vitro research on human embryos to 14 days post-fertilization. Under the rule, such research is permitted before the cut-off date at 14 days and prohibited thereafter.
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Ketamine Metabolite Could Inspire Fast-Acting Antidepressants
Chemical & Engineering News Share
Ketamine offers psychiatrists something that conventional antidepressants lack: speed. Most patients take selective serotonin reuptake inhibitors such as Prozac or Zoloft for weeks to months before they feel any improvement. But a single dose of ketamine can act within hours.
Unfortunately, the compound, used for decades as an anesthetic, comes with some downsides, including the potential for abuse as a psychedelic drug.
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SLAS Point-to-Point
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