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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit May 17, 2017    SLAS2018    Moving? New job? Let SLAS know.      




May 18 SLAS Webinar: High-Throughput Screening

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New Researchers, New Ideas: The Lab Man Talks with SLAS2017 Student Poster Competition Winners
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Alice Bong, Sudip Mondal and Bilal Zulfiqar took top honors in the SLAS Student Poster Competition at SLAS2017. The Lab Man, AKA SLAS Director of Education Steve Hamilton, talks with each about the work behind their winning posters, the challenges they encountered and what's next in their research and careers.

Bong is a Ph.D. candidate at the University of Queensland, Mondal a postdoctoral researcher at The University of Texas at Austin and Zulfiqar a Ph.D. student at Griffith Institute for Drug Discovery at Griffith University. Read more in the SLAS Electronic Laboratory Neighborhood e-zine and listen to the podcasts.

Game On: Spain vs. Switzerland vs. United Kingdom!
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No, it's not the World Cup. It's an all-Europe five-person final in the 2017 SLAS Discovery and SLAS Technology Art of Science Contest. It's up to you — the life sciences discovery and technology community — to determine who will score the grand prize of a $500 USD Amazon gift card.

Vote for the scientific image you like best before the game is over at 5 p.m. U.S. Eastern time on Friday, May 19.

SLAS2017 Screen Design and Assay Technology SIG Meeting Presentation Now Online
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Adam Weinglass and Mary Jo Wildey of Merck & Co. share their well-received SLAS2017 Special Interest Group meeting presentation, "Cell-Based In Vitro Assay Automation: Balancing Technology & Data Reproducibility/Predictability." GPCRs are modulated by many marketed drugs and continue to be key targets for drug discovery and development.

One of the assay technologies used in these discovery efforts is the homogenous time-resolved fluorescence IPOne (IP1) cell-based functional assay, using adherent cells. Learn about different technology options for removing assay media prior to compound addition and determination of IP1 accumulation.

Flawless High-Throughput NA QC

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SLAS is Now Accepting Abstracts for SLAS2018
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The Scientific Program Committee is accepting abstract submissions in 10 educational tracks for SLAS2018, Feb. 3-7, San Diego, CA. Podium abstracts are due by Monday, Aug. 7.

Abstracts should describe original research and will be assessed according to the novelty of the work with an emphasis to abstracts that clearly detail results. Students: be sure to apply for an SLAS Tony B. Academic Travel Award when you submit your podium or poster abstract.

Make a Bigger Splash in Life Sciences With the SLAS Journals
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Read the SLAS journals to advance your research. Publish in the SLAS journals to advance your professional success.

The life sciences community counts on the rigorously peer-reviewed SLAS Discovery (Advancing Life Sciences R&D) and SLAS Technology (Translating Life Sciences Innovation) journals to gain scientific insights; increase productivity; elevate data quality; reduce process cycle times; and enable research and development that would otherwise be impossible.


The Chemical Biology Discussion Group Year-End Symposium on May 24
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The New York Academy of Sciences invites interested members of the SLAS community to this one-day event, featuring keynote presentations from New York University's Dirk Traunder, Ph.D., and The Rockefeller University's Sean F. Brady, Ph.D.

Chemical biology is a dynamic field that explores chemical approaches to studying and manipulating biological systems. The symposium addresses a range of topics in chemical biology including chemical probe development, organic synthesis, biosynthesis, protein engineering, nanotechnology and drug discovery.


Lab Unveils 'Heart-on-a-Chip'    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Prescription drugs have enabled millions of Americans with chronic medical conditions to live longer and more fulfilling lives, but many promising new drugs never make it to the human trials stage due to the potential for cardiac toxicity. Through "heart-on-a-chip" technology — modeling a human heart on an engineered chip and measuring the effects of compound exposure on functions of heart tissue using microelectrodes — Lawrence Livermore National Laboratory researchers hope to decrease the time needed for new drug trials and ensure potentially lifesaving drugs are safe and effective while reducing the need for human and animal testing. More

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Molecular Dynamics, Machine Learning Create 'Hyper-Predictive' Computer Models
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Drug development is a costly and time-consuming process. To narrow down the number of chemical compounds that could be potential drug candidates, scientists utilize computer models that can predict how a particular chemical compound might interact with a biological target of interest — for example, a key protein that might be involved with a disease process. Traditionally, this is done via quantitative structure-activity relationship (QSAR) modeling and molecular docking, which rely on 2- and 3-D information about those chemicals. More

FDA Approves First New ALS Drug in More than 20 Years
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The Food and Drug Administration has approved the drug Radicava, also known as edaravone, for the treatment for amyotrophic lateral sclerosis (ALS). This is the first time an ALS drug has been cleared for use in the U.S. since the drug riluzole was approved in 1995. The Centers for Disease Control and Prevention estimates between 12,000 and 15,000 people in the U.S. are living with ALS, commonly referred to as Lou Gehrig's disease. More

Hydrogen Tunneling above Room Temperature Evidenced by Infrared Ion Spectroscopy
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
While hydrogen tunneling at elevated temperatures has, for instance, often been postulated in biochemical processes, spectroscopic proof is thus far limited to cryogenic conditions, under which thermal reactivity is negligible. We report spectroscopic evidence for H-tunneling in the gas phase at temperatures around 320–350 K observed in the isomerization reaction of a hydroxycarbene into an aldehyde. The charge-tagged carbene was generated in situ in a tandem mass spectrometer by decarboxylation of oxo[4-(trimethylammonio)phenyl]acetic acid upon collision induced dissociation. More

Screening of Wolbachia Endosymbiont Infection in Aedes aegypti Mosquitoes Using Attenuated Total Reflection Mid-Infrared Spectroscopy
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Dengue fever is the most common mosquito transmitted viral infection afflicting humans, estimated to generate around 390 million infections each year in over 100 countries. The introduction of the endosymbiotic bacterium Wolbachia into Aedes aegypti mosquitoes has the potential to greatly reduce the public health burden of the disease. This approach requires extensive polymerase chain reaction (PCR) testing of the Wolbachia-infection status of mosquitoes in areas where Wolbachia–A. aegypti are released. More

US Visa Change Could Impact Chemists
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Some foreign scientists who want to travel to the U.S. may have to provide far more information in visa applications than they do now, under a White House proposal. Last week, the State Department released a plan to expand its collection of visa information such as social media handles and family connections for some travelers seeking both visitor and immigrant visas. The move was in response to a March 6 executive order by President Donald J. Trump. More

Two Genetic Wrongs Make an Anticancer Right
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
It sounds counterintuitive: Lose the function of one tumor suppressor gene or another, and the result is faster tumor growth. But lose the function of both tumor suppressor genes, and the result is slower tumor growth. Yet such a counterintuitive effect has been observed by scientists at the Ludwig Institute for Cancer Research. They report that the tumor suppressor genes PTEN (phosphatase and tensin homolog) and DAXX (death domain associated protein), along with the H3.3 histone protein, participate in interactions that may epigenetically enhance or inhibit tumor growth. More

Folk Contraceptives Lead Researchers to Drugs That Block Fertilization
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Two chemicals found in anti-fertility folk medicines block a key step in fertilization — the meeting of egg and sperm — and may make effective alternatives to today's hormone-based contraceptives, which sometimes cause side effects. The chemicals are effective at low doses that seem to have no adverse effect on egg or sperm, other than to prevent the sperm from pushing through the cells that congregate around the egg and an enveloping membrane called the zona pelucida. More


Postdoctoral Associate in Mouse Models of Stroke
University of Minnesota Medical School
US – MN – Duluth

Three Research Associate Positions in Personal Technologies for Affective Health
Lancaster University
UK - Lancaster

Research Scientist High-Throughput Screening
US – MA – Boston

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