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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit May 21, 2014    SLAS2015    Moving? New job? Let SLAS know.    




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Get Published! SLAS Journal Special Issues on Deck
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Special issues published by SLAS's two MEDLINE-indexed scientific journals (JALA and JBS) are always widely read and highly rated. Manuscript proposals for three upcoming special issues are now being accepted (due dates noted in parentheses). More


SLAS ELN Reports: Develop Wise Skills to Achieve Career Goals
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A recent Ph.D. has had three job interviews in the last month and just heard back from her most promising one: "The people from HR just contacted me. They let me know that they have chosen another person."

In the latest feature article in the SLAS Electronic Laboratory Neighborhood e-zine, career consultant Dan Eustace discusses how a better understanding and application of wise skills could have made her the chosen candidate.

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Tony B. Academic Travel Award Deadline is July 28
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Airfare, SLAS2015 conference registration and hotel accommodations are provided to recipients of these valuable awards. Apply via the SLAS2015 abstract submission site; opt in for award consideration. July 28 is the due date for proposed podium presentations. Poster abstracts for consideration in this award program may be submitted until Sept. 22.

A total of 46 students, graduate students, post-doc researchers and junior faculty members received Tony B. awards to present their scientific achievements at SLAS2014.

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Francis Collins Addresses Senate Appropriation Committee on Biomedical Research
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"Today I have provided you with examples of how investments in biomedical research through NIH are advancing human health, spurring innovations in science and technology, and providing significant economic benefits to our nation. The opportunities have never been better, but America is now at a critical juncture. Continued investment in biomedical research will lead to health advances and economic growth."

Read the full April 29 speech, Driving Innovation through Federal Investments, from the NIH director and SLAS2015 keynote speaker.

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Protein-Protein Interactions as Small Molecule Drug Targets Webinar Series On Demand
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All three highly-attended, highly-rated SLAS Webinars in this series now are available FREE to SLAS dues-paid members. Review the complete list of archived SLAS Webinars on topics like phenotypic drug discovery, R&D partnerships in Asia, data management and More.

New at JBS: Rank Ordering Plate Data Facilitates Data Visualization and Normalization in High-Throughput Screening
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A team from McMaster University in Canada presents a method of high-throughput screening data visualization and normalization that is effective, intuitive, and easy to implement in a spreadsheet program. They use biochemical and cell-based high-throughput data sets to show that normalization by the mean of the interquartile (middle 50%) of the data on each plate is an effective method of minimizing variability.

Like the Z score, the interquartile method avoids the potential problems of control-based normalization; however, since only the middle 50 percent of the data is used for normalization, the interquartile method has the advantage of not being influenced by the outliers on the plate.

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    Research Leads to New Understanding of How Cells Grow, Shrink
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    For a century biologists have thought they understood how the gooey growth that occurs inside cells causes their protective outer walls to expand. Now, Stanford researchers have captured the visual evidence to prove the prevailing wisdom wrong. The finding may lead to new strategies for fighting bacterial diseases. "What we observed was not what we had expected," said K.C. Huang, an assistant professor of bioengineering and of microbiology and immunology and the senior author of the findings. More

    Pros and Cons of Open-Plan Science
    Chemistry & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Board the ferry from central Amsterdam for Buiksloterweg on a weekday morning, and it's likely you'll be sharing it with some of more than 900 scientists from Shell's open-plan research center on the other side of the river. Until the building was commissioned in 2009, one would watch these scientists, who may study catalysts or detergent formulations for recovering shale oil, quietly splinter off from Buiksloterweg to workspaces in about 40 research buildings in the area. More


    Researchers Develop Chip-Like Cell-Sorting System
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    An international team has developed a cell-sorting system that they hope will revolutionize research: a chip-like device that could be scaled up to sort and store hundreds of thousands of individual living cells, enabling single-cell analysis. The team consisted of researchers from Duke University and Daegu Gyeongbuk Institute of Science and Technology in the Republic of Korea, and their study, "Magnetophoretic circuits for digital control of single particles and cells," appeared online in Nature Communications. More

    A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion
    ACS Chemical Biology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Signal transducer and activator of transcription 3 (STAT3) plays important roles in multiple aspects of cancer aggressiveness including migration, invasion, survival, self-renewal, angiogenesis, and tumor cell immune evasion by regulating the expression of multiple downstream target genes. STAT3 is constitutively activated in many malignant tumors and its activation is associated with high histological grade and advanced cancer stages. More

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    Nanotech Poster Absorbs Pollution
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    A scientist and an award-winning poet, both at the University of Sheffield, have made a giant poster that uses nanotechnology to gobble up pollution. It can absorb the poisonous compounds from around 20 cars each day if you put it by a busy road. Professor Tony Ryan (the science expert) and professor Simon Armitage (the words expert) came up with the idea to highlight one possible way to cut disease and save lives by taking poisonous compounds from the air. More

    Tobacco Plants May Contain Cure for Cancer, a New Twist in Protein-Lipid Interactions
    Live Science    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Scientists at La Trobe University published a study about a protein found in the flowers of ornamental tobacco plant that targets human cancer cells and destroys them. This raises the prospect of the deepest kind of irony: tobacco grown to produce drugs used to treat cancers caused by tobacco. Mark Hulett, Marc Kvansakul and others from the Biochemistry Department used a range of techniques to examine the structure and function of a protein called NaD1. More

    Immune-Boosting Drug Shows Promise Against Lung Cancer
    New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Cancer has one less place to hide. A drug that stops tumors camouflaging themselves from the immune system appears to significantly boost survival rates in people with a form of lung cancer that is almost incurable unless removed surgically before it spreads. Some people who received the drug have seen their tumors disappear completely. More

    Using Nature as a Model for Low-Friction Bearings    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The mechanical properties of natural joints are considered unrivalled. Cartilage is coated with a special polymer layer allowing joints to move virtually friction-free, even under high pressure. Using simulations on Jülich's supercomputers, scientists from Forschungszentrum Jülich and the University of Twente have developed a new process that technologically imitates biological lubrication and even improves it using two different types of polymers. More

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