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SLAS
Last year was an exciting year of innovation and growth for SLAS. Read about the firsts, flexibility and future-thinking in Growing with the Changes, 2018 Annual Report.
VIEW THE ANNUAL REPORT
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SLAS
The deadline to submit podium abstracts for the 2019 SLAS Americas Sample Management Symposium has been extended to Monday, June 3. Podium abstracts are being accepted for four different session topics:
- Enabling Drug Discovery: Target Validation to Pre-Clinical
- Innovative Technology and Process Optimization
- Enabling New Medicines: From Candidate to Clinic
- The Common Threads Across All Sample Types: Challenges of Sample Management Quality and Compliance
Save the date for this upcoming symposium in Boston, MA, USA, November 20-21.
COMPLETE SUBMISSION DETAILS
PROGRAM INFORMATION
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PRODUCT SHOWCASE | Advertisement
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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SLAS
The latest SLAS Discovery issue features the cover article, "A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction" by Timothy M. Willson, Ph.D., (University of North Carolina and Structural Genomics Consortium), is now accessible through June 20. Read about how Willson and his team of researchers from UNC used an open sharing concept to explore new medicines, specifically small molecule kinase inhibitors. Willson outlines how they leveraged the pooled knowledge of the scientific community to develop several dark proteins as potential drug targets.
READ THE COMPLETE ARTICLE
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SLAS
June's issue of SLAS Technology features a special collection of articles based on the content from the SLAS 2018 Americas Sample Management Symposium. The issue leads with cover article, "Next Generation Compound Delivery to Support Miniaturized Biology," which outlines the challenges of changing the established screening paradigm to support the needs of modern drug discovery, including the shift from traditional screening methods to the use of more miniaturized biology approaches with disease-relevant cells and tissues. Full access is available until June 20. Abstract submission for 2019 Americas Sample Management Symposium is extended to June 3.
ACCESS JUNE'S SLAS TECHNOLOGY
SLAS
Do you have interesting and impactful research to be published? SLAS currently has two opportunities for upcoming and seasoned researchers, scientists and students to share their research proposals within our two peer-reviewed journals, SLAS Discovery and SLAS Technology.
SLAS Technology: Carbohydrate Structure Analysis: Methods and Applications
Topics include: Mass spectrometry of oligosaccharides or glycoconjugates, NMR techniques for carbohydrate structure analysis, higher order structures and more.
Submission deadline: Friday, May 31
COMPLETE SUBMISSION INSTRUCTIONS
SLAS Discovery: Functional Genomics for Target Identification
Topics include: Functional genomics screening aimed at the identification of novel therapeutic targets and pathways, understanding the emergence of drug resistance mechanisms, generating novel hypothesis for combination therapies and patient stratification and more.
Submission deadline: Sunday, June 30
COMPLETE SUBMISSION INSTRUCTIONS
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Anton Paar’s Modular Sample Processor allows pipetting, sampling, dosing and weighing to be automated. Available as a benchtop unit or a complete solution integration. MORE
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SLAS
SLAS Journal Special Issues Call for Papers
SLAS Technology: Carbohydrate Structure Analysis: Methods and Applications
May 31: Proposals due
SLAS Discovery: Functional Genomics for Target Identification
June 30: Proposals due
October 31: Invited submissions due
Upcoming 2019 Events
SLAS Europe 2019 Conference and Exhibition
June 26 - 28
Short Courses: June 25
Barcelona, Spain
Exhibit and sponsorship opportunities available
Save the Dates
SLAS 2019 AI in Process Automation Symposium
October 3 - 4
Boston, MA
Exhibit and Sponsorship Opportunities Available: Contact Karen Layser
SLAS 2019 Advanced 3D Human Models and High-Content Analysis Symposium
October 21 - 22
London, UK
SLAS 2019 Americas Sample Management Symposium — Call for Podium Abstracts Extended to June 3
November 20 - 21
Boston, MA
Monday, June 3: Podium Abstract Submission Deadline
Sponsorship Opportunities Available: Contact Karen Layser
SLAS2020 International Conference and Exhibition
January 25 - 29, 2020
San Diego, CA
Call for Podium and Poster Abstracts Now Open
COMPLETE LIST OF SLAS CONFERENCES AND SYMPOSIA
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Designed for simple retrofitting within fume hoods and biosafety cabinets, the Rooster™ is a fast, reliable, and affordable way to monitor airflow safety and achieve OSHA or NSF-49/ANSI compliance. The Rooster™ Alarm can be configured with three types of sensors and allows for a variety of customization for alarming behaviors.
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Science Magazine
Passive transfer of neutralizing antibodies can protect against disease caused by chikungunya virus, an emerging mosquito-borne pathogen. However, effective treatment of chikungunya-infected patients with symptomatic disease using antibodies will require identification of high-potency immunoglobulins and an efficient platform for delivering them to patients. Kose et al. screened immortalized human B cells from a chikungunya survivor and identified a monoclonal IgG antibody with exceptional neutralizing capacity.
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Science Daily
Tissue engineering could transform medicine. Instead of waiting for our bodies to regrow or repair damage after an injury or disease, scientists could grow complex, fully functional tissues in a laboratory for transplantation into patients.
Proteins are key to this future. In our bodies, protein signals tell cells where to go, when to divide and what to do. In the lab, scientists use proteins for the same purpose.
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Genetic Engineering & Biotechnology News
Diving deep into patient data, researchers based at the University of Pittsburgh School of Medicine have uncovered four novel sepsis phenotypes. The phenotypes, shown to differ with respect to demographics, laboratory values, and patterns of organ dysfunction, appear to correlate with biomarkers and mortality. Overall, the newly characterized phenotypes emphasize that sepsis isn't just one condition. Rather, sepsis comprises many conditions that could benefit from different treatments.
READ MORE
The Scientist
During gene editing with CRISPR technology, the Cas9 scissors that cut DNA home in on the right spot to snip with the help of guide RNA. The way the genetic material is stitched back together afterward isn't terribly precise, though; in fact, scientists have long thought that without a template, the process is random. However, "there's been anecdotal evidence that cells don't repair DNA randomly," geneticist Richard Sherwood of Brigham and Women's Hospital said.
READ MORE
Lab Manager
Researchers have developed a new compact, fiber-based imaging spectrometer for remote sensing that can capture 30,000 sampling points each containing more than 60 wavelengths. This rich spectral information combined with high spatial resolution provides valuable insight into the chemical makeup of a scene or sample.
"Compact imaging spectrometers such as the one we developed can be used on unmanned aerial vehicles to help increase crop production or inform response after a disaster based on detected pollution," said research team leader Tomasz S. Tkaczyk from Rice University.
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Laboratory Equipment
Gastric cancer, Q fever, Legionnaires' disease, whooping cough — though the infectious bacteria that cause these dangerous diseases are each different, they all utilize the same molecular machinery to infect human cells. Bacteria use this machinery, called a Type IV secretion system, to inject toxic molecules into cells and also to spread genes for antibiotic resistance to fellow bacteria. Now, researchers at Caltech have revealed the 3-D molecular architecture of the T4SS from the human pathogen Legionella pneumophila with unprecedented details.
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Phys.org
Hydrogenases are enzymes that catalyze hydrogen activation. There are three types of hydrogenases in nature, all containing iron and some of them nickel. But in synthetic chemistry there is a whole host of metals that can activate molecular hydrogen and catalyze hydrogenation reactions.
"Why doesn't nature use other metals in hydrogenases? Is it purely due to bioavailability?" asks Xile Hu, head of the Laboratory of Inorganic Synthesis and Catalysis at EPFL.
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Chemical & Engineering News
Vertex Pharmaceuticals is buying into the burgeoning field of protein degradation through a four-year pact with fellow Cambridge, Massachusetts–based biotech firm Kymera Therapeutics. Kymera will receive $70 million, including an equity investment, from Vertex, which will get an exclusive option to license any drugs that emerge from the deal.
The partners will develop protein degraders for a set of undisclosed drug targets.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
Career Connections Exclusive: Two Postdoctoral Positions Now Available at Scripps
Apply for one of two postdoctoral positions at one of the world's largest independent non-profit research facilities. Both positions will work within the laboratory of SLAS Fellow and Scripps’ Senior Scientific Director Tim Spicer, Ph.D.
FULL POSITION DESCRIPTION
Investigator III, Discovery Bioanalytical Sciences
Novartis
US – MA
Laboratory Automation Engineer
Oxford Immunotec
US – MA – Norwood
Research & Technology Advisor/Chemist - New Product Development
Albemarle Corporation
US – LA – Baton Rouge
Search Jobs at SLAS Career Connections
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