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  Mobile version   RSS   Subscribe   Unsubscribe   Archive   Media Kit May. 23, 2012

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JALA unveils new podcast series
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The first in a new podcast series at JALA Online is entitled "A Conversation with the Authors of Automation of Cell-Based Drug Absorption Assays in 96-Well Format Using Permeable Support Systems." The podcast features June JALA cover story authors Brad Larson of BioTek Instruments and Mark Rothenberg of Corning Life Sciences with JALA Podcast Editor David Pechter of Merck Research Laboratories. Larson and Rothenberg explain how their Apparent Permeability (Papp) and Efflux data demonstrate how an automated procedure, when compared to manual processing, provides a method that is less variable and is capable of delivering a more accurate assessment of a compound's absorption characteristics. More

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New SLAS PDD LinkedIn subgroup takes off
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The Phenotypic Drug Discovery Forum attracted about 100 members in its first week. Get involved in the discussion on PDD research and related topics such as target identification/validation, chemical diversity, chemical genomics, chemo-informatics, poly-pharmacology, translational pharmacology, model systems and patient tailoring. This is one of 16 SLAS subgroups and the overall SLAS LinkedIn group generating conversations among peers. More

Talented SLAS member Jan Wagner shares his story
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"Working in laboratory automation and playing in a local rock band complement one another nicely," says SLAS member Jan Wagner, Dresden, Germany. This new SLAS Electronic Laboratory Neighborhood member profile discusses Wagner's work at LiCONiC Instruments and the Max Planck Institute of Molecular Cell Biology and Genetics, as well as his play with the band Nine a.m. More



Small automated pipettors perform big
SOLO & SOLOPlus Automated Pipettors are the perfect choice for automating repetitive and time consuming applications. Available in single channel, 8-channel and 12- channel configurations the SOLO handles serial dilutions, kinase assays and next-gen sequencing prep with ease. Multiple deck configurations, accessories and robotics are available. See more at http://www.hudsonrobotics.com/PRODUCTS/Liquid-Handling. Email info@hudsonrobotics.com.


Promega grant allows student attendance at SLAS Asia Conference
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Five students will attend the SLAS Asia Conference and Exhibition June 19-21 in Shanghai thanks to a generous sponsorship from Promega Corporation. Dong Wang, Shu-Ting Liu and Ming Li study with Jinfeng Hu, Ph.D., professor and head of Department Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai, China. Ming Ma and Yanzhen Ye work with Jeff Xi, Ph.D., professor at Peking University's Department of Biomedical Engineering, Beijing. More

SLAS2013 exhibits are 80 percent sold
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Find ways to solve real-world challenges in your laboratories by exploring the new and emerging technologies offered by exhibitors at the Second Annual SLAS Conference and Exhibition, Jan. 12-16, Orlando. Pre-walk the exhibit floor by viewing the robust interactive floorplan, and find those companies offering innovative solutions of interest to you. More


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JBS free access through June 29
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Encourage your colleagues to explore the Journal of Biomolecular Screening! Through June 29, the top 10 read articles in this SLAS journal are open to those without a subscription. Articles include "Sirtuin 1 (SIRT1): The Misunderstood HDAC," by Walter Stünkel and Robert M. Campbell; "A High-Content Screen Identifies Inhibitors of Nuclear Export of Forkhead Transcription Factors," by David C. Bouck et al.; and "Open Innovation for Phenotypic Drug Discovery: The PD2 Assay Panel," by Jonathan A. Lee, et al. More

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$54.7 million awarded to universities for research equipment
U.S. Department of Defense    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The Department of Defense announced plans to award $54.7 million to academic institutions to support the purchase of state-of-the-art research equipment. The 190 awards to 100 academic institutions are being made under the Defense University Research Instrumentation Program that augments current university capabilities or develops new university capabilities to perform cutting-edge defense research. More

2 patients get eye stem cells transplanted to restore sight
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Two people have had stem cells transplanted into their eyes as part of a clinical trial to restore their sight. The technique has been developed by Scottish specialists to reverse corneal blindness, and it is believed to be the first treatment of its kind in the U.K. Both have corneal blindness, and until now the only treatment was a transplant of cornea tissue from an organ donor. More


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Investigate major signaling pathways
Cisbio provides a panel of cellular kinase assays dedicated to the measurement of site-specific phosphorylation, in an endogenous cellular environment. These homogeneous assays represent a reliable, robust and rapid alternative to classical technologies like Western Blot, ELISA or bead-based assays.
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Alpaqua Magnet Plates... Like No Other
ALPAQUA® offers 24-well, 96-well & 384-well magnet plates with integrated spring technology for touch-off dispensing and complete supernatant removal while eliminating costly tip crashes and occlusions. Strong NdFeB magnets enable rapid, reliable bead capture and retention. Alpaqua magnet plates are SBS compliant and compatible with many liquid handlers, plate hotels & stackers.


Comparison of behavior of metal-organic frameworks and zeolites for hydrocarbon separations
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The objective of this work was to study the adsorption and separation of the most important families of hydrocarbon compounds on metal–organic frameworks, in comparison with zeolites. For this purpose, we have selected four probe molecules, each of them representing one of these families, i.e., o- and p-xylene as aromatics, 1-octene as an alkene, and n-octane as an alkane. More

Visualization and quantitative analysis of G protein-coupled receptor — β-arrestin interaction in single cells and specific organs of living mice using split luciferase complementation
ACS Chemical Biology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Methods used to assess the efficacy of potentially therapeutic reagents for G protein-coupled receptors have been developed. Previously, we demonstrated sensitive detection of the interaction of GPCRs and β-arrestin2 using 96-well microtiter plates and a bioluminescence microscope based on split click beetle luciferase complementation. More



Physical properties predict stem cell outcome
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Tissue engineers can use mesenchymal stem cells derived from fat to make cartilage, bone or more fat. The best cells to use are ones that are already likely to become the desired tissue. Brown University researchers have discovered that the mechanical properties of the stem cells can foretell what they will become, leading to a potential method of concentrating them for use in healing. More

Folic acid may reduce some childhood cancers
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Folic acid fortification of foods may reduce the incidence of the most common type of kidney cancer and a type of brain tumors in children, finds a new study by Kimberly J. Johnson, PhD, assistant professor at the Brown School at Washington University in St. Louis, and Amy Linabery, PhD, postdoctoral fellow at the University of Minnesota. More


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Integrated nanopore sensing platform with sub-microsecond temporal resolution
Nature Methods    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Nanopore sensors have attracted considerable interest for high-throughput sensing of individual nucleic acids and proteins without the need for chemical labels or complex optics. A prevailing problem in nanopore applications is that the transport kinetics of single biomolecules are often faster than the measurement time resolution. Methods to slow down biomolecular transport can be troublesome and are at odds with the natural goal of high-throughput sensing. More

Scientists identify key metastasis-enabling enzyme
Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Recently, scientists at the Leibniz Research Centre for Working Environment and Human Factors, University of Dortmund, Germany, studying the tumor metabolome — the characteristic metabolic phenotype of tumor cells fundamental to the tumor's metastatic capacity — identified EDI3 as the enzyme responsible for a decreased glycerophosphocholine to phosphocholine ratio by cleaving GPC to produce choline. More

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Immune system strength at birth linked to quantity of baby's colds
Live Science    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The number of colds babies have in their first year of life can range from none to 10, a new study finds. And the quantity of colds was linked to the innate strength of the babies’ immune systems at birth. The science of it is complex, but in a nutshell, the researchers extracted certain cells in blood from newborn's umbilical cords, exposed those cells to a common respiratory virus (in a lab setting) and determined the strength of the responses. More

Survey: 'Rare' genetic variants are surprisingly common
eBioNews    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A large survey of human genetic variation, published in the online version of the journal Science, shows that rare genetic variants are not so rare after all and offers insights into human diseases. A team of life scientists studied 202 genes in 14,002 people. The human genome contains some 3 billion base pairs; the scientists studied 864,000 of these pairs. More


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Fast replication or reformatting of 96 and 384 well plates and high precision transferring of reagents, compounds and solutions to or from microplates is now as easy as pipetting with a standard electronic pipette into a single tube.
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Get your free automation consultation
Astech Projects launch new turnkey approach to automation at SLAS! Composed of four key steps – consultation & proposal, concept design study, proof of concept, and detailed design, manufacture and testing – Astech currently offers the initial consultation & proposal free of charge. Apply for yours today.


Career


Integrated Circuit Reverse Engineer/Scientist
Battelle
USA – OH – Columbus

Assistant Research Scientist
NYU Langone Medical Center
USA – NY – New York

Institute Research Scientist, In Vitro Pharmacology
MD Anderson Cancer Center
USA – TX – Houston

More jobs at SLAS Career Connections


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