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SLAS Discovery Special Issue on 3D Cell Culture, Drug Screening, and Optimization
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"Cultured primary human cells, and those derived from induced pluripotent stem cells, have been used in basic research and drug discovery for many years," say Guest Editors Richard M. Eglen, Corning Life Sciences and Jean-Louis Klein, GlaxoSmithKline. "Yet it is only comparatively recently that such cells, when cultured in 3D, have been routinely prepared and employed in robust experimental protocols, some of which are now amenable to high-throughput automation and detection. The emerging data are providing new insights not only into cell fundamental biology, but also in terms of better screening systems for novel agents entering clinical evaluation."
Learn more in the SLAS Discovery June 2017 special issue with free online access to select articles sponsored by Corning Life Sciences. 
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From the SLAS President: SLAS Education — Moving with the Times and the Targets
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"Because SLAS is a member-focused and member-led society, we continually align and refine our educational programs to meet the evolving interests and challenges of the people on the frontlines of basic and applied life sciences discovery and technology," says SLAS President Scott Atkin. "Our members' voices determine the direction we take with our programs, products, services and events."
Atkin talks specifically about the process behind the launch of three new scientific tracks at SLAS2018 in the SLAS Electronic Laboratory Neighborhood e-zine.
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SLAS Technology Special Issue on Personalized and Precision Medicine: Making N-of-1 Medicine a Reality
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"The fields of personalized and precision medicine promise substantial improvements in treatment outcomes across a broad spectrum of indications ranging from oncology to infectious diseases and cardiovascular medicine," say Guest Editors Dean Ho and Ali Zarrinpar of the University of California, Los Angeles. "The immense potential of these disciplines has led to important advances in profiling patient genomic information to better prescribe treatment regimens; applying engineering approaches to dynamically optimize and personalize combination therapy in a continuous fashion; and tracking treatment progress using a spectrum of biomarkers."
These advances are featured in the 11 peer-reviewed, original research reports from Switzerland, Sweden, Singapore, Spain and the United States in the special issue available now at SLAS Technology Online for select SLAS Premier members, Premier Plus members, SLAS Technology subscribers and pay-per-view readers.
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Upcoming SLAS Europe Events: Dates and Deadlines
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Take note of two exciting SLAS Europe events!
The SLAS Europe 2017 Nordic Chemical Biology Meeting is June 6-7, Copenhagen Denmark. Register now to learn about quality/analysis of libraries prior to screening, open innovation initiatives, chemoproteomics and cancer immunotherapy from experts like Adam Nelson of the University of Leeds, Thomas Andresen of Technical University of Denmark, Steve Rees of AstraZeneca.
The SLAS Europe 2017 High-Content Screening Conference is Sept. 19-20 in Madrid, Spain. Scientific abstract proposals from research scientists, engineers, academics and business leaders are being accepted until Monday, June 5. Conference topics revolve around four topics: data analysis, screening, technology and model systems.
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Abstracts Due June 1 for SLAS Discovery DNA-Encoded Chemical Libraries and SLAS Technology Cell-Based Therapies Special Issues
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Special issues of SLAS Discovery and SLAS Technology are hallmarks of editorial excellence, popular with readers and highly cited. Manuscript proposals (abstracts) for original research reports, reviews, perspectives and technical notes/technology briefs are being accepted through June 1 for special issues on these important topics:
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Mark Your Calendar for SLAS2018
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It's full speed ahead to San Diego, Feb. 3-7, at the San Diego Convention Center! SLAS is accepting podium and poster abstracts for the scientific program along with Tony B. Academic Travel Award applications, two keynote speakers have been named, the schedule-at-a-glance is online, and exhibit and sponsorship opportunities are available.
Watch for additional SLAS2018 announcements in the months ahead.
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Scientists Design New Protein Structure
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A team of chemists and biochemists from the Bristol BioDesign Institute have designed a new protein structure.
This is much simpler than most naturally occurring proteins, which has allowed the scientists to unpick some of the molecular forces that assemble and stabilise protein structures. The work is published in the journal Nature Chemical Biology.
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Beyond Just Promise, CRISPR is Delivering in the Lab Today
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There's a revolution happening in biology, and its name is CRISPR.
CRISPR is a powerful technique for editing DNA. It has received an enormous amount of attention in the scientific and popular press, largely based on the promise of what this powerful gene editing technology will someday do.
CRISPR was Science magazine's 2015 Breakthrough of the Year; it's been featured prominently in the New Yorker more than once; and The Hollywood Reporter revealed that Jennifer Lopez will be the executive producer on an upcoming CRISPR-themed NBC bio-crime drama.
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Chemists May Be Zeroing in on Chemical Reactions That Sparked the First Life
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DNA is better known, but many researchers today believe that life on Earth got started with its cousin RNA, because that nucleic acid can act as both a repository of genetic information and a catalyst to speed up biochemical reactions. But those favoring this "RNA world" hypothesis have struggled for decades to explain how the molecule's four building blocks could have arisen from the simpler compounds present during our planet's early days.
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Gene Therapy for Age-Related Macular Degeneration Safe in Humans
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Wet age-related macular degeneration occurs when blood vessels grow and leak fluid into the macula, the central portion of the retina. If left untreated, this condition can lead to vision loss. A new gene therapy that blocks vascular endothelial growth factor, a protein that plays a central role in the development of the disease, may be a safe treatment, according to a study published in the Lancet.
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New HIV Vaccine Strategy Could Be Key to Thwarting Virus
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Drugs that help slow down and control the infection caused by the human immuodeficiency virus (HIV) are an important therapeutic modality. However, preventing the spread of this deadly disease through the development of prophylactic vaccines is essential for disease elimination. Yet, attempts thus far at creating an effective HIV vaccine have been met with limited success. Now, new research, paves the way for vaccines that boost the parts of the immune system attacking the viral genes, which are the least active during the infection.
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New Role in Cells Suggested for ATP
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Adenosine triphosphate (ATP) performs many jobs in a cell. It carries energy, serves as a signaling molecule, and is the source of adenosine in DNA and RNA.
But cells contain far more ATP — as much as 5 mM in the cytoplasm — than these known uses seem to require. That might be because ATP also can solubilize proteins, suggests a new study.
ATP has the general characteristics of a hydrotrope, an amphiphilic molecule that has both a hydrophilic and a hydrophobic component but does not assemble into structures such as micelles.
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Researchers Apply New Immune Technologies in Search of Mono Vaccine
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A research lab at the University of Kansas School of Engineering and School of Pharmacy is analyzing the genetics of human immune responses to develop the basis of an effective vaccine or drug therapy against Epstein-Barr Virus, or EBV, the pathogen that causes mono and infects around 90-percent of adults worldwide.
The virus, which commonly spreads during teen years and young adulthood via kissing, has hit-or-miss health consequences.
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Shapeshifting Materials: Using Light to Rearrange Macroscopic Structures
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Traditional chemistry is immensely powerful when it comes to producing very diverse and very complex microscopic chemical molecules. But one thing out of reach is the synthesis of large structures up to the macroscopic scale, which would require tremendous amounts of chemicals as well as an elaborate and complicated technique. For this purpose, scientists rely instead on "self-assembling" molecules, compounds that can interact with other copies of themselves to spontaneously congregate into spheres, tubes or other desired shapes.
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Regenerative Medicine – Faculty Position
The Houston Methodist Research Institute
US – TX – Houston
Postdoctoral Associate in Mouse Models of Stroke
University of Minnesota Medical School
US – MN – Duluth
Search Jobs at SLAS Career Connections
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