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SLAS ELN Reports — 2015 SLAS Innovation Award Winner Jonathan Wingfield: Bringing Screening with Mass Spectrometry to the Next Level
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"I remember vividly when I decided to go into drug discovery," Wingfield recalls. "I was doing basic research on transcription factors in the hospital's research lab. That day, I walked into the cafeteria — there was only one for both staff and patients — and sat down among all the children, so many of whom were seriously ill. I remember thinking to myself, 'I've had nine years of education, but I'm not making a difference. I have to do something more productive and helpful.' "

Read more about Wingfield's award-winning work combining mass spectrometry and acoustic droplet ejection in the SLAS Electronic Laboratory Neighborhood e-zine.
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New! Assay Guidance Workshop for High-Throughput Screening and Lead Discovery
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This full-day workshop at SLAS2016 provides participants with a broad, practical perspective on assay development to:
  • Better understand the process of high-throughput screening/lead discovery and where to find further information
  • Identify reagents, methods and instrumentation that are well suited for robust assays
  • Be able to develop assays and counter assays for new targets
  • Seek practical advice about individual research challenges
This workshop to be held Saturday, Jan. 23, 2016 in San Diego, CA, includes an overview of the National Center for Advancing Translational Sciences/National Institutes of Health Assay Guidance Manual.
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June Issue of JBS Now Online for Members and Subscribers
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"High-Throughput Hit Screening Cascade to Identify Respiratory Syncytial Virus (RSV) Inhibitors," "A Whole-Cell Assay for Specific Inhibitors of Translation Initiation in Bacteria" and "Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression" are original research articles included in the June issue.

SLAS Biomolecular Sciences Section members and JBS subscribers now can view the complete issue at JBS Online. All are invited to view the open access article, "A Multiplexed Cell-Based Assay for the Identification of Modulators of Pre-Membrane Processing as a Target against Dengue Virus from a team at San Diego State University.
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SLAS Edinburgh Conference Photo Gallery
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SLAS and the Scottish Universities Life Science Alliance (SULSA) combined to present Cutting-edge Technologies for Drug Target Validation Conference, May 18-19 in Edinburgh, UK. The conference featured keynote lectures by Lorenz Mayr of AstraZeneca (Strategies for Target Validation); Chas Bountra of the University of Oxford (Validation of Pioneer Targets for Drug Discovery); and William Janzen of Epizyme (Technology Integration in Drug Discovery).

Additional scientific sessions, poster presentations and networking events rounded out the event. Thank you to the SLAS Europe Scientific Committee: Manfred Auer, David Cronk, Stuart McElroy, Neil Carragher and Steve Rees.
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SLAS is Now Accepting SLAS2016 Tony B. Academic Travel Award Applications
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Tony B. awards provide airfare, full conference registration, hotel accommodations and the opportunity to participate fully in SLAS2016, Jan. 23-27 in San Diego, CA.

Students, graduate students, post-doctoral associates and junior faculty may apply for this prestigious travel award by submitting a podium or poster abstract. Podium abstracts are due Aug. 3 and poster abstracts can be submitted as late as Sept. 21.
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Protect Your Scholarly Identity
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Register now with ORCID to secure a unique identifier for yourself so editors, funding agencies, publishers and institutions can reliably recognize you in the same way that ISBNs and DOIs identify books and articles. ORCID supports automated linkages between you and your professional activities to ensure your work is properly recognized.

Once you have an ORCID ID, be sure to add it to your user profile in JALA SAGEtrack and JBS SAGEtrack. Registration is fast, free and easy.
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Modern Alchemy: Chemists Devise Synthesis of Valuable Exotic Compounds
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Chemists at The Scripps Research Institute have discovered a broad and strikingly inexpensive method for synthesizing "amines," a class of organic compounds prominent in drugs and other modern products. The new reaction is particularly useful for synthesizing complex amines that would be highly valuable in pharmaceuticals, but are impractical — or impossible — to make with standard methods. More

New Approach To Control Enzyme Function In Cells
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A new technique could make it easier to target and inhibit specific enzymes and other proteins in cells and to turn that regulation on and off at will with light. The approach provides researchers with another tool to study the function of proteins in their natural cellular environments. In the study, researchers selectively inhibit enzymes by covalently tethering small-molecule inhibitors to target proteins. More

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DNA Mutations Get Harder to Hide
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Rice University researchers have developed a method to detect rare DNA mutations with an approach hundreds of times more powerful than current methods. The technique allows the researchers to find a figurative needle in a haystack that's smaller than any needle. The researchers applied their new molecular tools to 44 DNA samples with known cancer-related single-nucleotide variants. More


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One Step Closer to a Single-Molecule Device
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A new technique to create a single-molecule diode has been developed by scientists, and, in doing so, they have developed molecular diodes that perform 50 times better than all prior designs. This research group is the first to develop a single-molecule diode that may have real-world technological applications for nanoscale devices. More

Blood to Feeling: Scientists Turn Blood into Neural Cells
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Scientists at McMaster University have discovered how to make adult sensory neurons from human patients simply by having them roll up their sleeve and providing a blood sample. Specifically, stem cell scientists at McMaster can now directly convert adult human blood cells to both central nervous system (brain and spinal cord) neurons as well as neurons in the peripheral nervous system (rest of the body) that are responsible for pain, temperature and itch perception. More



Inexpensive Technique Developed to Manufacture Nanofibers
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Scientists at the University of Georgia say they have developed an inexpensive way to manufacture nanofibers, which are polymers made from natural materials like proteins or from human-made substances to make plastic, rubber or fiber, including biodegradable materials. The new method, dubbed "magnetospinning," provides a simple, scalable, and safe means for producing large quantities of nanofibers that can be embedded with a multitude of materials. More

Study Maps Prenatal Cells
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A new study, published online by Amander Clark, Ph.D., at the UCLA Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, significantly furthers the understanding of the human germline — the cells that create eggs or sperm in humans during prenatal development in the womb. The highly specialized cells of the germline, called germ cells, are the only cell type in the body capable of passing parents' genes on to their biological children. More

Science Still Seen as Male Profession, According to International Study of Gender Bias
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Close your eyes and imagine a scientist: peering into a telescope, flicking a glass vial in a lab, or sitting at a computer typing out a grant proposal. Did you picture a man or a woman? The answer depends on where you live, according to a new study. Researchers have found that people in some countries are much more likely to view science as a male profession, with the Netherlands coming in at the top of the list. Regardless of location, though, the stereotype persists that science is for men. More

Career


Research Group Leader/Epigenetics and Chronic Obstructive Pulmonary Disease
BioMed X Innovation Center
Germany – Heidelberg

Associate Director, Large Molecule Bioanalytical Group
SNBL USA
US – WA – Everett

Supplier Quality Manager
Nanotherapeutics
US – FL – Gainesville

More jobs at SLAS Career Connections


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