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From the SLAS President: SLAS Journals — The Forces that Fuel Innovation
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"It's no wonder that when surveyed, SLAS members always acknowledge that they highly value their journal subscriptions and that the journals are a top reason for being members of our Society," says SLAS President Daniel G. Sipes in the new From the SLAS President column in the SLAS Electronic Laboratory Neighborhood e-zine.

"Now in their nineteenth years of publication, SLAS's two official scientific journals (JALA and JBS) continue to blaze new trails for life science R&D professionals."
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JALA Online: Special Issue on New Developments in Global Health Technologies
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"As you read through this issue, we hope you will share our excitement and enthusiasm for the work that is being done in global health research," says JALA Guest Editor Peter B. Lillehoj, Ph.D., of Michigan State University. "Although there is still much to be done before we live in a world where health care is readily available and accessible to everyone, regardless of where they live, every technological advancement and scientific discovery brings us one step closer to achieving this goal."

The special issue includes "Centrifugo-Magnetophoretic Purification of CD4+ Cells from Whole Blood Toward Future HIV/AIDS Point-of-Care Applications," by Macdara Glynn and a team from Dublin City University, Ireland, which also is featured in the JALA podcast.
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JBS Online: Special Issue on Knowledge from Small-Molecule Screening & Profiling Data
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The new issue from JBS Guest Editors Paul A. Clemons, Ph.D., of Broad Institute and Darren Green, Ph.D., of GlaxoSmithKline opens with a review article on the development of BARD, a fourth-generation repository and knowledge environment for small-molecule science.

Two additional reviews, including the open access "Increasing the Content of High-Content Screening: An Overview," precede the original reports of multiple perspectives on the maturation of high-throughput and high-content screening as technologies.
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SLAS2015 Call for Abstracts — Are You Participating?
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SLAS invites research scientists, engineers, academics and business leaders to submit abstracts to be considered for presentation at SLAS2015, the 4th Annual SLAS Conference and Exhibition, Feb. 7-11, Washington, DC. Both podium and poster abstracts can be submitted now.

The SLAS2015 website includes key dates, requirements, track descriptions, general instructions, a sample abstract and an abstract submission form. Take advantage of this opportunity to present your work to an audience that includes prestigious leaders in the laboratory science and technology community.
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LabAutopedia Seeks Volunteer Authors
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Engage with the No. 1 scientific wiki focused on the world's laboratory technology knowledge. It is easy to set up your account and contribute articles of interest to the community. LabAutopedia offers definitions and terminology, standards, white papers, organizational listings, and other information that is continually evolving and constantly growing collaboratively by numerous authorities of various related fields, including academics, users/practitioners and vendors. LabAutopedia currently boasts nearly 500 articles and close to 1.4 million page views. More


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End-to-End Chemistry
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A modern pharmaceutical manufacturing plant looks a lot like a classical chemistry lab. As has been the case for more than a century, most drugs that come out of these factories are made via stepwise reactions, purifications, and final product formulation. In a handful of plants, however, continuous-flow processes are starting to creep in. Continuous processing offers several advantages over start-and-stop batch production. More

DNA Nanotechnology Places Enzyme Catalysis Within Arm's Length
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Using molecules of DNA like an architectural scaffold, scientists have developed a 3-D artificial enzyme cascade that mimics an important biochemical pathway that could prove important for future biomedical and energy applications. In the latest breakthrough, the research team took up the challenge of mimicking enzymes outside the friendly confines of the cell. These enzymes speed up chemical reactions, used in our bodies for the digestion of food into sugars and energy during human metabolism, for example. More


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    Warring with Cancer Avatars to Expose Unique Vulnerabilities of Real Tumors
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Cancer avatars, much like avatars in video and computer games, may become dynamic characters, not just collections of visual features. If cancer avatars are developed on the basis of genomic profiles, they can reflect the signaling and metabolic complexities of real cancers. What's more, a cancer avatar, set loose in a virtual world — call it TumorSpace — may interact with different adversaries — drugs, say — and experience different fates. More

    Immune System's 'Rules of Engagement' Discovered
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A study led by researchers at Stanford's School of Medicine reveals how T cells, the immune system's foot soldiers, respond to an enormous number of potential health threats. X-ray studies at the Department of Energy's SLAC National Accelerator Laboratory, combined with Stanford biological studies and computational analysis, revealed remarkable similarities in the structure of binding sites, which allow a given T cell to recognize many different invaders that provoke an immune response. More

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    System 'Prints' Precise Drug Dosages Tailored for Patients
    Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Drug makers now manufacture tablets based on clinical studies that determine the average recommended dose. Often this average falls outside of the optimal dose for a particular patient, but there is no way to precisely adjust the dosage except by trial and error. "Pharmaceutical companies make one or two or three dosage levels, so people try breaking tablets in half and other methods to get to the right dosage," said Gintaras "Rex" Reklaitis, Purdue University's Burton and Kathryn Gedge Distinguished Professor of Chemical Engineering. More

    Pfizer Pulls Plug on AstraZeneca Takeover
    Drug Discovery & Development    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Pfizer said Monday that it does not intend to make a takeover offer for British drugmaker AstraZeneca, pulling the plug for now on what would have been the largest deal in the industry's history. The announcement came a week after AstraZeneca's board rejected a $119 billion buyout proposal from Pfizer, the world's second-biggest drugmaker by revenue. More


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    Breakthrough Method for Making Janus or Patchy Capsules
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Hollow capsules that have a selectively permeable shell are promising candidates as tiny containers for molecules, particles or bubbles, and are becoming increasingly important in a wide variety of applications. But making these kinds of capsules with more than one kind of substance on their shells has been challenging — until now. More

    Instructional Solid State ChIP Technology Video Available
    Chromatrap     Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A new instructional video explains exactly how to conduct a ChIP assay for epigenetic research starting from a confluent monolayer of human cells. The video was prepared to inform researchers of an optimized protocol for preparing fresh chromatin from a dish of growing cells and how to verify the quality of the chromatin recovered. In addition each simple step in the Chromatrap procedure is shown, leading to measurable amounts of high-purity chromatin ready for PCR or sequencing. This video is an essential primer for those contemplating the technique, but who have yet to perform a ChIP assay. More



    Single Molecular Resistive Switch Obtained via Sliding Multiple Anchoring Points and Varying Effective Wire Length
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A single molecular resistive (conductance) switch via control of anchoring positions was examined by using a molecule consisting of more than two same anchors. For this purpose, we adopted the covered quaterthiophene (QT)-based molecular wire junction. The QT-based wire consisted of two thiophene ring anchors on each side; thus, shift of anchors was potentially possible without a change in the binding modes and distortion of the intramolecular structure. More

    Superbug Crisis: Global Push to Save Antibiotics Begins
    New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    "A post-antibiotics era in which common infections and minor injuries can kill, far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century." That was the warning last month from the World Health Organization in its first global report on the growing ability of bacteria to resist antibiotics. More


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