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A Conversation on Centrifugal Microfluidics with JALA Author Ling X. Kong
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Centrifugal microfluidics has experienced much growth in recent years, especially in applications such as lab-on-a-disc (LoD) diagnostics. The strength of LoD systems lies in their potential for development into integrated sample-to-answer analysis systems.

Author Ling X. Kong talks about her review of the technologies necessary to develop next gen systems, valving and other fluid-handling operations; and the future of LoD reagent storage, sample prep, nucleic acid amplification and analyte detection strategies in this new JALA podcast. Her review, "Lab-on-a-CD: A Fully Integrated Molecular Diagnostic System," can be found in the June issue of JALA.
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SLAS2017 Podium Presentation Abstracts Due Aug. 8
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"As at any good conference, there are many reasons to attend and present one's work," says Lenny Teytelman of Protocols and SLAS2017 Data Analysis and Informatics Track chair. "However, SLAS stands out with its unusual fusion of industry and academic participants. This is true both for the presenters and the audience at large. It is often surprisingly fruitful to encourage mixing of researchers from different fields, and it is equally true for mixing academic and industry scientists."

Associate track chair Margaret DiFilippo of Dotmatics adds: "The diversity of the attendees at the SLAS conference enables presenters to promote their organizations to various potential collaborators. The conference program is extremely well organized — there is ample time to network between talks, posters and social events." See detailed track and session descriptions as well as more reasons to submit an abstract for SLAS2017 on the SLAS2017 website.
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SLAS Europe: High-Content Screening Conference, June 27-29, Dresden, Germany
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SLAS Europe invites researchers, academics and industry professionals to explore the latest advances and emerging technologies in the field, including the hot topics of novel organisms, novel markers, new essays, novel microscopy techniques, image analysis and statistics.

Organized by co-chairs Marc Bickle of the Max Planck Institute of Molecular Cell Biology and Genetics (Germany), Thierry Dorval of Servier (France) and Maria Montoya of Centro Nacional de Investigaciones Cardiovasculares (Spain), conference speakers represent a wealth of institutions, including the European Molecular Biology Laboratory, Hungarian Academy of Sciences, Institute of Cancer Research, King's College London, Memorial Sloan Kettering Cancer Center and OcellO.
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New and Free at JBS Online: Characterization of Differentiated SH-SY5Y as Neuronal Screening Model Reveals Increased Oxidative Vulnerability
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This Luxembourg Centre for Systems Biomedicine study presents an optimized neuronal differentiation protocol for SH-SY5Y that requires only two work steps and six days. After differentiation, the cells present increased levels of ATP and plasma membrane activity but reduced expression of energetic stress response genes.

The authors are convinced that their differentiation method will leverage genetic and chemical high-throughput screening projects targeting pathways involved in the selective vulnerability of neurons with high energetic stress levels. This is a SAGE Choice article, allowing all readers immediate free access to the full manuscript.
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SLAS Webinars and SLAS2016 Presentations Available On-Demand
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High-content single-cell screening, droplet microfluidics, metagenomics, automated 3D cell culture, smartlabs, mass spectrometry and gene editing are among the topics explored in the robust SLAS on-demand collection of SLAS International Conference presentations and SLAS Webinars. Presenters span the breadth of life sciences discovery and technology and share their expertise in these immediately accessible recordings.

The most recent addition to the library is "Addressing the Challenges of 1536-Well Cell-Based Screening" from scientist Helen Plant at AstraZeneca, U.K. Dues-paying SLAS members can access at SLAS.org for free.
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European Leaders Call for 'Immediate' Open Access to All Scientific Papers by 2020
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In what European science chief Carlos Moedas calls a "life-changing" move, European Union member states agreed on an ambitious new open access (OA) target. All scientific papers should be freely available by 2020, the Competitiveness Council — a gathering of ministers of science, innovation, trade, and industry — concluded after a two-day meeting in Brussels. But some observers are warning that the goal will be difficult to achieve. More


Technology Offers Path to 'Clean, Safe' Chemical Production
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From fragrances and food flavorings to the building blocks of pharmaceutical drugs, fine chemicals — complex chemicals produced in small quantities to a high degree of purity — play a major role in our daily lives. But producing these chemicals can come at a cost, both in monetary terms and the large amount of waste generated. A new technology called HydRegen promises to make the production of fine chemicals "cheaper, faster, safer and cleaner." More


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Venoms Provide Paradoxical Path to Promising Drug Discovery
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Investigators led by scientists at The Scripps Research Institute (TSRI) say they have invented a technique for rapidly identifying various venoms that strike a specific target in the body and then optimizing such venoms for therapeutic use. The researchers demonstrated the new method by using it to identify venoms that block a certain protein on T cells, Kv1.3, which is implicated in multiple sclerosis, rheumatoid arthritis, and other inflammatory disorders. More


Synthesis of Platinum Nanotubes and Nanorings via Simultaneous Metal Alloying and Etching
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Metallic nanotubes represent a class of hollow nanostructures with unique catalytic properties. However, the wet-chemical synthesis of metallic nanotubes remains a substantial challenge, especially for those with dimensions below 50 nm. This communication describes a simultaneous alloying-etching strategy for the synthesis of Pt nanotubes with open ends by selective etching Au core from coaxial Au/Pt nanorods. More




Next-generation Gene Sequencing Helps Diagnose Rare Diseases in Newborns
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The use of next-generation gene sequencing in newborns in neonatal intensive care units (NICUs) may improve the diagnosis of rare diseases and deliver results more quickly to anxious families, according to new research in the Canadian Medical Association Journal. "Next-generation sequencing has the potential to transform the practice of clinical genetics rapidly," writes Dr. David Dyment, Children's Hospital of Eastern Ontario (CHEO), with coauthors. More


Mass Spec Weighs in on Protein Therapeutics
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Proteins — especially antibodies — are gaining in popularity in the pharmaceutical industry, both as drugs in their own right and as targeting agents for other drugs. In fact, these so-called biologics have been part of the therapeutic landscape for so long that some have already come off patent. Last year, the U.S. Food & Drug Administration approved the first generic, or biosimilar, version of a biologic drug — Zarxio, a version of the bone marrow stimulator filgrastim made by Sandoz. More


Beating the Limits of the Light Microscope, One Photon at a Time
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The world's most advanced light microscopes allow us to see single molecules, proteins, viruses and other very small biological structures — but even the best microscopes have their limits. Now scientists are pushing the limits of a technique called super-resolution microscopy, opening potential new pathways to illuminating, for example, individual cell processes in living tissue at unprecedented resolutions. More


Challenges of a Shared Instrument Lab
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The Shared Instrument Facility (SIF) is used for both teaching and research in the department, as well as for usage by external clients. The SIF is a great platform for different areas within chemistry — analytical, physical, organic, and inorganic — to integrate. For example, a materials lab for teaching was created to integrate inorganic chemistry with physical chemistry. Before the SIF was created, the branches of chemistry were much more segregated. More


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Archer Daniels Midland Co.
US – IL – Decatur

Scientist III, Lead Discovery
Dart NeuroScience
US – CA – San Diego

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Rutgers Brain Health Institute
US – NJ – Piscataway

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