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SLAS
A new SLAS Discovery article available now for free ahead-of-print, offers perspective from researchers at Coyne Scientific (Atlanta, GA, USA) about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials. CTiD allows pharmaceutical companies to test, at the population level, novel drugs on patient cells before moving into actual clinical trials. Because current preclinical strategies don't follow this principle, CTiD offers the potential to significantly impact drug discovery and development. Image by Coyne Scientific.
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SLAS
"SLAS has allowed the scientists and engineers at Labcyte to interact more fully with the scientific community. It's not just an exhibition for us. We have been fortunate to do real science and get the opinions of real scientists that are attending the meeting," says Joe Olechno, senior research fellow at Labcyte (San Jose, CA, USA). Learn how Labcyte propelled its growth by leveraging the focus that SLAS has on collaboration and the ability to enable life sciences innovation. Available now on the SLAS YouTube channel.
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SLAS
The SLAS Nominations Committee will soon select three individuals to join the SLAS Board of Directors for three-year terms of service beginning in 2019. Candidate applications are being accepted now through Monday, July 2, 2018. All candidates must have the capacity and commitment to serve, and meet the required criteria outlined in the SLAS Board of Directors Selection Policy, the SLAS Bylaws and the SLAS Disclosure Form. The new board members will replace those completing their terms: Sabeth Verpoorte, Ph.D., from the University of Groningen (Groningen, The Netherlands), Peter Grandsard, Ph.D., Amgen (Thousand Oaks, CA, USA) and Ian Shuttler, Ph.D., Tecan Trading AG (Zurich, Switzerland).
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Because drug discovery involves scientists from multiple disciplines and often organizations, it is critical to have an efficient mechanism for researchers to collaborate and realize the collective value of their specialized knowledge, assets, and capabilities. This free white paper details the essential keys to effective collaboration.
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SLAS
Register now to hear Keynote Speaker Tyler Mulvihill at the 2018 SLAS Americas Sample Management Symposium, Nov. 13-14, 2018, in Boston, MA (USA). Mulvihill, co-founder at Viant, ConsenSys (New York), will discuss how exponential technologies like blockchain will affect the way samples are managed. Complete scientific program now online! Poster abstracts being accepted until Monday, Aug. 27. Register before Monday, Oct. 1 to save $150.
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BMG Labtech
Optimizing binding kinetics offers potential clinical benefits. A novel approach determines kinetic parameters such as on- and off-rates by continuous time-resolved FRET reads. This way, the PHERAstar FSX microplate reader simultaneously measures kinetics of hundreds of compounds. Prof. Steven Charlton (Nottingham University) explains how he studies kinetics of ligand-receptor binding.
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SLAS
Three tracks form the foundation of an exciting scientific program featuring 50 presentations from thought leaders throughout Europe at the 2018 SLAS Europe Conference and Exhibition, June 27-29, Brussels, Belgium. Learn more about presentations for Track 1, Emerging Investigative Biology, which includes: "Biological Mechanisms Involved in Aging and Degenerative Diseases," "Exploring Target Biology" and "The Impact of New Technologies on the Treatment of Rare Diseases." The poster abstract submission deadline has been extended to June 8.
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SLAS
"When biostatisticians and biomedical scientists work together — early and often — the end result is more satisfying science," says Paul Kayne, Ph.D., of Bristol-Myers Squibb (Princeton, NJ, USA). Kayne and Robert Nadon, Ph.D., of McGill University (Montreal, Quebec, Canada), are guest editors of the June 2018 SLAS Discovery Special Collection on Statistical Applications in Knowledge and Drug Screening.
The duo reveals insights about the collection in a new article in the SLAS Electronic Laboratory Neighborhood (SLAS ELN).
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SLAS
Advances in Bioanalytics and Biomarkers is one of 10 educational tracks that form the foundation of the SLAS2019 Scientific Program. This track will highlight important developments in bioanalytical technologies, including advances in label free technologies, applications of target and mechanism deconvolution techniques, and approaches to biomarker analysis within in vitro and in vivo models. Plan to participate: Podium abstracts are due Monday,
Aug. 6.
Students: Apply for an SLAS Tony B. Academic Travel Award when you submit your podium or poster abstract. The travel award application and podium abstract deadline is Monday, Aug. 6. The deadline for travel awards for poster abstract submissions is Monday, Sept. 24.
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Analytical Chemistry
At or below the surface of painted works of art, valuable information is present that provides insights into an object's past, such as the artist's technique and the creative process that was followed or its conservation history but also on its current state of preservation. Various noninvasive techniques have been developed over the past two decades that can probe this information either locally (via point analysis) or on a macroscopic scale (e.g., full-field imaging and raster scanning).
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Genetic Engineering & Biotechnology News
Scientists at the University of Texas at Austin say they have developed a new technique to make therapeutic proteins more stable. They believe their advance will improve the drugs' effectiveness and convenience, leading to smaller and less frequent doses of medicine, lower health care costs and fewer side effects for patients with cancer and other diseases. Their study appears in Nature Biotechnology.
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When high-throughput tip dispensing is needed, the Lab Services’ PlateButler® TipHotel could be suitable for you. This device provides robot-friendly storage of tips and is known for the optimal use of the available bench top capacity.
Contact us for more information.
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Journal of the American Chemical Society
α-Amanitin is an extremely toxic bicyclic octapeptide isolated from the death-cap mushroom, Amanita phalloides. As a potent inhibitor of RNA polymerase II, α-amanitin is toxic to eukaryotic cells. Recent interest in α-amanitin arises from its promise as a payload for antibody–drug conjugates. For over 60 years, A. phalloides has been the only source of α-amanitin. Here we report a synthesis of α-amanitin, which surmounts the key challenges for installing the 6-hydroxy-tryptathionine sulfoxide bridge, enantioselective synthesis of (2S,3R,4R)-4,5-dihydroxy-isoleucine, and diastereoselective sulfoxidation.
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Phys.org
Tuberculosis, a lung disease that spreads in the air through coughs or sneezes, now kills more people worldwide than any other infectious agent, according to the World Health Organization's latest global tuberculosis report. And in hundreds of thousands of cases each year, treatment fails because the bacteria that cause Tb have become resistant to antibiotics.
Now an international team of researchers has found a new way to investigate how Tb bacteria inactivate an important family of antibiotics: They watched the process in action for the first time using an X-ray free-electron laser, or XFEL.
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Chemical & Engineering News
In the early years of this decade, excitement began to ripple through the cancer community about medicines called PD-1 inhibitors. By blocking proteins that tumors use to slow down the immune system, they were having a powerful effect against some types of cancer. Many oncologists vividly recall their first patient to experience a turnaround after treatment with the new immunotherapy drugs.
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Lab Manager
Deep brain stimulation has been used to treat Parkinson's disease symptoms for 25 years, but limitations have led researchers to look for ways to improve the technique. This study describes the first fully implanted DBS system that uses feedback from the brain itself to fine-tune its signaling. The study was supported by the National Institutes of Health's Brain Research through Advancing Innovative Technologies (BRAIN) Initiative and the National Institute of Neurological Disorders and Stroke (NINDS).
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Science Daily
Enzymes are tools of nature that accelerate almost all biochemical reactions in living cells as biological catalysts. For this reason, enzymes have been used in the chemical industry for some time now — in detergents and cleaners, toothpastes and shampoos, but also in foods. Enzymes help in the production of paper, textiles, leather, medicines, biofuels and other products.
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Bioscience Technology
An international team led by researchers from the Technion-Israel Institute of Technology and NYU Langone Health has succeeded in stopping the growth of mesothelioma in model animals by inhibiting the heparanase enzyme.
Mesothelioma is a cancer that develops in the mesothelium — a thin membrane that protects the internal organs of the chest and abdomen. In most cases, the disease is caused by exposure to asbestos.
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Senior Research Associate / Associate Scientist, BioAg Assay Development - RTP NC
Novozymes North America
US – NC – Durham
Associate Director for Research - Geriatric Research, Education and Clinical Center
Veteran Health Administration
US – AR – Little Rock
Postdoctoral Position in Brain-Computer Interfaces
University of Geneva
Switzerland – Geneva
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