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SLAS ELN Reports: Making N-of-1 Medicine a Reality
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SLAS Technology Guest Editors Dean Ho and Ali Zarrinpar dig deep into journal special issue papers that discuss advances in personalized and precision medicine with the hope of turning terminal illnesses into chronic issues. The 11 peer-reviewed, original research reports from Switzerland, Sweden, Singapore, Spain and the U.S. explore applications such as using high-throughput screening to access cystic fibrosis mutations, utilizing cell culture assays to predict drug resistance in cancer therapy, applying automated flow cytometry toward measuring pharmacological profiles in acute myeloid leukemia and analyzing multiple biomarkers for sepsis detection.

Experience the guest editors' insight in this SLAS Electronic Laboratory Neighborhood e-zine feature article. Listen to the podcast.


2017 SLAS Europe Nordic Chemical Biology Meeting This Week
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The June 6-7 meeting at the University of Copenhagen focuses on quality/analysis of libraries prior to screening, open innovation initiatives, chemoproteomics, cancer immunotherapy and antimicrobial resistance and infectious disease. Conference Chair Mads H. Clausen of the Technical University of Denmark led the program compilation which features presenters from AstraZeneca, Harvard University, Max Planck Institute of Colloids and Interfaces, Medical Research Council Laboratory of Molecular Biology, University of Geneva and University of Leeds among others.

For last-minute arrangements, call SLAS Europe at +32(0) 2.739.30.26 or e-mail

Vlassakis and Loise Share Career-Building Insight at Gordon Research Seminar
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As co-chair of the June 3-4 Gordon Research Seminar on Physics and Chemistry of Microfluidics, 2017 SLAS Graduate Education Fellowship Grant winner Julea Vlassakis organized a panel, "Mentorship Component: The Future of Microfluidics and Your Impact in an Evolving Field." Seeking to highlight opportunities beyond the research bench, Vlassakis turned to SLAS CEO Vicki Loise to share important skills scientists need to succeed if their career path takes them into the realm of scientific societies or associations. "Managing conflict, running an effective meeting, understanding strategic planning and communicating to different audiences are important business skills."

Pictured here are all seminar presenters; in the front row, Vlassakis is second from left and Loise on far right.

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Explore SLAS2018 Educational Tracks
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Advances in Bioanalytics and Biomarkers is one of 10 SLAS2018 educational tracks accepting podium abstract submissions until Aug. 7. Track Chairs Melanie Leveridge of GlaxoSmithKline and Shaun McLoughlin of Abbvie believe the qualitative and quantitative characterization of endogenous and exogenous analytes in biological systems are the basis of drug discovery and development. This track highlights important developments in bioanalytical technologies, including advances in label free technologies, applications of target and mechanism deconvolution techniques and omics approaches to biomarker analysis.

See track session descriptions and the benefits of presenting on the SLAS2018 website.

SLAS Journals Invite Special Collection Proposals
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SLAS Discovery and SLAS Technology invite proposals from interested guest editors for collections of five to seven original scientific reports that collectively explore the different dimensions, recent achievements and existing challenges related to a timely topic of interest and importance to SLAS journal readers. Special collections published recently include: Learn about how you can contribute as guest editor and work closely with the journal editor-in-chief. More



Better Targeting, Delivery of RNAi Therapies
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Historically, most therapeutics have been small chemicals and antibodies designed to target cellular proteins. New kinds of therapeutics are emerging, however, from a better understanding of noncoding RNAs (ncRNAs), such as the microRNAs (miRNAs) and short interfering RNAs (siRNAs), that participate in RNA interference (RNAi). Now that RNAi pathways are being mapped, drug developers can exploit newfound mechanisms of action and realize pharamacologic windfalls. More

Chemists Forge a New Path in the Search for Antibiotics    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Yale University scientists have developed a novel chemical process that may lead to the creation of a new class of antibiotics. The discovery comes at a time when more types of bacteria are becoming resistant to existing antibiotics, increasing the occurrence of lethal infections. The ability to create new antibiotics would have significant ramifications for medical treatment and public health, said the researchers. More

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Drugs Score Big Wins Against Lung, Prostate, Breast Cancers
The Associated Press via Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Drugs are scoring big wins against common cancers, setting new standards for how to treat many prostate, breast and lung tumors. There's even a "uni-drug" that may fight many forms of the disease. What's striking: The drugs are beneficial in some cases for more than a year, much longer than the few months many new drugs provide. More

More Than 1 Percent of Clinical Trial Reports Appear Flawed
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Analyzing 5,087 randomized controlled trials published between January 2000 and December 2015, John Carlisle, a consultant anesthetist at Torbay Hospital in the U.K., has found around 80 papers that raised cause for concern, with more than half very likely to contain errors in key data. Some of these papers have already been retracted, but many stand in the scientific literature. More

Engineered Bacteria Detect Gut Inflammation in Mice
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A new strain of engineered bacteria can detect inflammation in the colon of mice even after more than 1,000 bacterial divisions, researchers report. Such a microbe could help doctors diagnose and monitor diseases such as inflammatory bowel disease. Pamela A. Silver and coworkers at Harvard University engineered nonpathogenic Escherichia coli to detect and respond to tetrathionate, a transient product of a reactive oxygen species released by intestinal cells during inflammation. More

Beyond Wicking: Expanding the Role of Patterned Paper as the Foundation for an Analytical Platform
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While a number of assays for soluble analytes have been developed using paper-based microfluidic devices, the detection and analysis of blood cells has remained an outstanding challenge. In this feature, we discuss how the properties of paper determine the performance of paper-based microfluidic devices and permit the design of cellular assays, which can ultimately impact disparities in healthcare that exist in limited-resource settings. More

Chemical 'Dance' of Cobalt Catalysis Could Pave Way to Solar Fuels
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By splitting a water molecule into two atoms of hydrogen and one of oxygen, scientists can use the boundless energy of the sun to make a clean fuel. In a new study from the U.S. Department of Energy's Argonne National Laboratory and Harvard University, scientists have for the first time been able to see an especially important step in the water-splitting process, which may bring us closer to abundant solar energy for all. More


Scientific Manager, Sample Management - Biomolecular Engineering Group
US – CA – South San Francisco

Associate Director for Clinical Chemistry
Geisinger Health System
US – PA – Danville

Sr. Laboratory Automation Engineer
Oxford Immunotec
US – MA – Norwood

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