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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit June 8, 2016

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SLAS ELN Reports: Combating CNS Disorders with Novel Screening Approaches, Collaborations
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New treatments for central nervous system (CNS) disorders are urgently needed, yet many companies have scaled back their work in this area, citing "high costs, lengthy development times and low success rates," according to an editorial in the June JBS Special Issue on Innovative Screening Methodologies to Identify New Compounds for the Treatment of Central Nervous System Disorders. Read about the novel screening approaches that could help turn the tide in the SLAS Electronic Laboratory Neighborhood e-zine feature article about the special issue.

Pictured is contributor Jeroen Kool of Vrije Universiteit Amsterdam, The Netherlands, with his institution’s newest nanospotting setup with mass spectrometer, nano/micro UPLC and the new prototype nanospotter of SPARK Holland for nanofractionation.
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New and Free at JBS Online: Characterization of Early Cortical Neural Network Development in Multiwell Microelectrode Array Plates
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As reported in a collaborative work of the University of Cambridge and the U.S. Environmental Protection Agency, neural network ontogeny was examined using microelectrode array (MEA) recordings made in multiwell MEA (mwMEA) plates over the first 12 days in vitro. Results demonstrated that network development on mwMEA plates is similar to development in single-well MEAs. The authors conclude that increased throughput of mwMEAs will facilitate screening drugs, chemicals or disease states for effects on neurodevelopment.

This SAGE Choice article, allowing all readers immediate free access to the full manuscript, is one of nine original research reports in the June JBS Special Issue on Innovative Screening Methodologies to Identify New Compounds for the Treatment of Central Nervous System Disorders.
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Begin to Plan Your SLAS2017 Experience
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SLAS2017 returns to Washington, DC, Feb. 4-8. Keynote presenters are in place. Tracks and session topics are planned. The call for podium presentation abstracts is gaining traction. And now, the preliminary schedule of events is online.

Short courses are Saturday and Sunday, and once again the SLAS2017 Exhibition runs Monday to Wednesday. The scientific program, including podium and poster presentations, tutorials and Special Interest Group meetings, takes place Monday to Wednesday, and the 2017 SLAS FUNd Run will be held Tuesday morning. Visit the SLAS2017 website to "Research the Possibilities" for staying current with new technologies, applications and ideas.
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JALA & JBS Global Spotlights on Denmark and Sweden
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The SLAS journal archives comprise 21 years of achievements from around the world, reflecting the breadth, depth and diversity of the SLAS life sciences discovery and technology community. In focus this quarter are recently published reports by JALA and JBS authors from Denmark and Sweden. More


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Job Seekers and Employers Connect via SLAS Career Connections
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Visit this targeted employment exchange regularly to keep up to date with job opportunities such as:
  • Automation engineer
  • Research automation scientist
  • Senior applications scientist, technical support – drug discovery/HTS technologies
  • Automation specialist, proteomics
  • Senior automation specialist (robotics), antibody engineering
Job seekers can post resumes and browse job openings for free. Employers can find new talent by reviewing posted resumes for free and attract new talent by posting job openings for a fee. Note: SLAS Corporate Members receive a 50% discount on job postings.
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'Human Genome Project-Write' Unveiled
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A team led by New York University's Jef Boeke, Harvard's George Church, and Andrew Hessel of the California-based commercial design studio Autodesk Research has published its proposal to synthesize entire genomes from scratch, including those of humans. Called the "Human Genome Project-Write" (the authors refer to the original HGP as Human Genome Project-Read), the initiative could take 10 years and a minimum of $100 million just to get started. More


Scientists Find Genetic Cause of Multiple Sclerosis
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Scientists at the University of British Columbia and Vancouver Coastal Health have proven that multiple sclerosis can be caused by a single genetic mutation — a rare alteration in DNA that makes it very likely a person will develop the more devastating form of the neurological disease. The mutation was found in two Canadian families that had several members diagnosed with a rapidly progressive type of MS. More


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Scientists Create Compound That Erases Disease-Causing RNA Defects
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In an important new study with implications for the treatment of dozens of incurable diseases, scientists from the Florida campus of The Scripps Research Institute have for the first time created a drug candidate that attacks and neutralizes the RNA structure that causes an incurable progressive, inherited disease involving a gradual loss of control over body movement. More


Toward On-Chip Mid-Infrared Sensors
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
This feature highlights recent advances on mid-infrared thin-film waveguide technology and on-chip photonics facilitating next-generation label-free chem/bio sensor and assay platforms. Complemented by more recent advancements toward on-chip semiconductor waveguides, it is anticipated that label-free integrated mid-infrared sensing schemes will readily complement existing chem/bio sensor technologies in applications ranging from process monitoring and environmental analysis to biomedical diagnostics and point-of-care devices. More




Cells Tap Nuclear Energy to Drive Urgent DNA Repair
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The cell's everyday energy needs are satisfied by adenosine triphosphate (ATP) molecules from mitochondria. But in extraordinary circumstances, alternative sources of ATP are available. For example, in fast-proliferating cancer cells, ATP can be generated in the cytoplasm. Because alternative ATP can be used to power cancer cells, it is in danger of getting a bad name. Alternative ATP, however, can serve useful purposes, too. More


New Chemical 'Sponges' Designed to Soak Up Toxic Cancer-Fighting Drugs After Targeting Tumors
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Doctors have a powerful arsenal of cancer-fighting chemotherapy drugs to choose from, though a key challenge is to better target these drugs to kill tumors while limiting their potentially harmful side effects. Now, researchers at the Department of Energy's Lawrence Berkeley National Laboratory are helping to develop and test materials for a new device that can be inserted via a tiny tube into a vein and soak up most of these drugs like a sponge. More


Mosquito Hunters Search for Zika Vectors
Science Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Zika virus, the once obscure pathogen now widely feared for causing birth defects and other problems, has spread very far, very quickly since an outbreak was first noticed in northeast Brazil in early 2015. It has reached more than 40 countries across the Americas, even making it to the Cape Verde islands, off the western coast of Africa. More than a million people have become infected along the way. More


Career


Automation Engineer
New York Genome Center
US – NY – New York

Ph.D. Scholarships in Cognitive, Computational and Social Neurosciences
IMT School for Advanced Studies
Italy – Lucca

Research Chemist
Michelman
US – OH – Cincinnati

Search Jobs at SLAS Career Connections


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