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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit June 10, 2015

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JBS Special Issue Call for Papers: Novel Targets and Screening Approaches for Neurodegenerative Diseases
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Guest editors Kevin D. Burris and Steven I. Dworetzky invite manuscript proposals by July 1, 2015. Areas of interest include current approaches to drug discovery in Alzheimer's, Huntington's, Parkinson's, ALS and other neurodegenerative diseases; emerging molecular targets/pathways for neuroprotection and disease modification; target identification and validation; disease-relevant assay systems; small molecules and/or biologics approaches; epigenetic screening approaches; and screens for imaging agents including diagnostics and/or pharmacodynamic biomarkers.

Invited authors will be notified by July 10 and final manuscripts will be due Nov. 1.
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New Scientific Track for SLAS2016: Cellular Technologies
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Advances in methodologies to control gene expression and to introduce reporters and sensors into cells, combined with technological advances in instruments measuring cellular events, have improved both target validation and cell-based screening efforts.

Therefore the SLAS2016 Annual Conference Program Committee has included a focused track on recent methodology and applications underlying gene editing approaches in target knockdown studies, the introduction of reporters into cells, as well as applications to control gene expression. Submit your work for consideration.
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From the LabAutopedia Book List — To Explain the World: The Discovery of Modern Science
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Nobel Prize-winning theoretical physicist Steven Weinberg published this commentary on the history of science from the Greeks to modern times in February 2015. To Explain the World: The Discovery of Modern Science explores how difficult it was to discover the goals and methods of modern science, and the impact of this discovery on human understanding and development.

In his trademark irreverent and compelling way, Weinberg tells stories of early scientists’ lack of understanding and historic clashes, as well as the impact of competing areas of religion, technology, poetry, mathematics and philosophy.
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SLAS2016 Opening Keynote: Expert on Multidrug Resistance in Human Cancer Cells
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Michael M. Gottesman, MD, National Cancer Institute, is deputy director for intramural research at NIH, where he oversees research and training in the federal laboratories. His research interests, reflected in over 500 publications, range from how DNA is replicated in bacteria to how cancer cells elude chemotherapy.

Gottesman will share his knowledge as the SLAS2016 opening keynote speaker on Jan. 25 in San Diego.
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Welcome to the Neighborhood!
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If you haven't been to the SLAS Electronic Laboratory Neighborhood e-zine lately, here's what's waiting for you: More



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Have You Visited the SLAS Webinar Archive Lately?
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The latest series of SLAS Webinars is now available on-demand: Recordings of 10 popular SLAS2015 presentations also are available in the webinar archive. On-demand access to SLAS Webinars is always free to dues-paid SLAS members. More

Attention JALA & JBS Authors & Reviewers: Update Your Info & Opt-in Today
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Be sure you receive important e-mail announcements by updating your personal profile information in the JALA and JBS SAGEtrack systems. Pay special attention to your "attributes" (areas of expertise) selections and be sure to "OPT-IN," so SLAS can keep you informed of special issues and other publication opportunities.
  • JALA SAGEtrack Users: Login, click on your name (top/right of homepage), select User ID & Password from the dropdown menu.
  • JBS SAGEtrack Users: Login, click on your name (top/right of homepage), select User ID & Password from the dropdown menu.
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Twists and Shouts: A Nanotube Story
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Pulickel M. Ajayan strolls across Rice University's campus as he talks on his cell phone. It's hot and humid by almost any standard, but in Houston, it's just another day. Maybe that's why Ajayan, founding chair of Rice’s materials science and nanoengineering department, is playing it so cool. "Go ahead," he says into the phone, a smile audible in his voice. "Ask me all the hard questions." More

Why Crystals Could Be The Shape of Future Pharmaceuticals
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Crystallization — the process of crystal formation via crystal growth — is typically employed in chemical manufacturing as a purification step or to isolate a final product and determine its quality. Despite its widespread uses, understanding the precise molecular mechanisms which occur during crystallization remains a scientific challenge, particularly for organic compounds. More


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Reprogramming of DNA Observed in Human Germ Cells for First Time
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A team of researchers led by the University of Cambridge has described for the first time in humans how the epigenome — the suite of molecules attached to our DNA that switch our genes on and off — is comprehensively erased in early primordial germ cells prior to the generation of egg and sperm. However, the study, published in the journal Cell, shows some regions of our DNA — including those associated with conditions such as obesity and schizophrenia — resist complete reprogramming. More

'Protein Map' Reveals Traffic of Life in a Cell
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Protein locations in a cell have been recorded in unprecedented detail as part of a "protein map" developed by University of Toronto scientists. The new map allows researchers to look much more closely into what happens in a cell when disease strikes and will also help scientists determine better treatments. Proteins, which are products of genes, are responsible for all workings of a cell. More



Turning Paper Industry Waste Into Chemicals
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Researchers at the KU Leuven Centre for Surface Chemistry and Catalysis have found a more eco-friendly way to derive lignin — a paper industry waste product — from wood and convert it into chemical building blocks. The resulting chemicals can be used in paint, insulation foam and several other products. The researchers published their findings in the journal Energy & Environmental Science. More

Test for ALS May Be on the Horizon
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists at the University of Toronto say they have uncovered novel insights on the genetic causes of Amyotrophic Lateral Sclerosis, also known as Lou Gehrig's disease. These findings could uncover a new way to detect a genetic predisposition to ALS before the disease strikes, notes the research team. A common mutation associated with ALS is an unstable repeated DNA sequence within the C9orf72 gene that could reach into the thousands. More

Merck Launches First New Antibiotic in 15 Years in UK
Drug Discovery & Development    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Merck has launched Sivextro in the United Kingdom, a drug designated for the treatment of acute bacteria skin and skin structure infections. Sivextro is a member of the oxazolidinone class of antibiotics. Pharmafile reports this is the first oral treatment to be released from this class of drugs since 2001 while also noting this announcement makes Merck "one of the only big pharma firms to return to this high-priority disease area" in close to 15 years. More

Drug for Low Sex Drive in Women?
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An advisory committee to the U.S. Food and Drug Administration voted 18-to-6 in support of the approval of flibanserin, which would be the first approved drug for the treatment of low sexual desire in women. There may be some restrictions, however. Doctors may have to become certified to prescribe the drug, which is only intended for women whose sexual troubles do not stem from recognizable causes (such as disease or relationship strife). More

Career


Vice Chair of Clinical and Translational Informatics
UC Davis School of Medicine
US – CA – Sacramento

Supplier Quality Manager
Nanotherapeutics
US – FL – Gainesville

R&D Engineer – Mechatronics
Flowserve Corporation
US – CA – Vernon

More jobs at SLAS Career Connections


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