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  Mobile version   RSS   Subscribe   Unsubscribe   Archive   Media Kit Jun. 13, 2012

SLAS.org    SLAS2013    Moving? New job? Let SLAS know.    


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SLAS awards $10,000 cash prize

The SLAS Innovation Award recognizes the work behind that one unique and special presentation at SLAS2013.



Expert Advice/Stimulating Conversation

Discussions and musings focused on the engaging field of laboratory science and technology.


 
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news


SLAS establishes an Endowed Fellowship at UCLA for novel drug development research
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SLAS President Dave Dorsett shares exciting news — an Endowed Fellowship at UCLA that broadens the SLAS reach and impact in the scientific community, and speaks directly to the SLAS mission and goals. The Endowed Fellowship supports a new UCLA School of Dentistry research program whose team will perform algorithm-driven feedback analysis to identify optimal combinations of nanodiamond-drug complexes, analogous to screening, to realize compounds that are capable of simultaneously maximized efficacy and safety. More

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SLAS2013 speaker advances work on fullerenes using high-resolution FT-ICR mass spectrometry
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1996 Nobel Prize in Chemistry Winner Sir Harold Kroto of Florida State University and his team observed the smallest fullerene to form spontaneously to date using metal atoms for stabilization. It is now possible that the fullerene, C28, could be tested for desirable properties such as high-temperature superconductivity. Their work is published in the Journal of the American Chemical Society, 2012, 134 (22). More

It's time to register for SLAS2013, Jan. 12-16, Orlando
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SLAS2013 registration is now open, and those who register by Oct. 31 will earn significant early bird discounts. Learn about optional short courses, explore travel options, see the latest on scientific sessions and register today. More



Small automated pipettors perform big
SOLO & SOLOPlus Automated Pipettors are the perfect choice for automating repetitive and time consuming applications. Available in single channel, 8-channel and 12- channel configurations the SOLO handles serial dilutions, kinase assays and next-gen sequencing prep with ease. Multiple deck configurations, accessories and robotics are available. See more at http://www.hudsonrobotics.com/PRODUCTS/Liquid-Handling. Email info@hudsonrobotics.com.


New scientific discoveries in JBS Online manuscripts
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"High-Throughput Screening of a Diversity Collection Using Biodefense Category A and B Priority Pathogens," "BacMam System for FRET-Based cAMP Sensor Expression in Studies of Melanocortin MC1 Receptor Activation" and "Development of a High-Content High-Throughput Screening Assay for the Discovery of ATM Signaling Inhibitors" are now exclusively available (ahead of print) at JBS Online. Delve into these and many more articles available to SLAS Biomolecular Sciences Section members. More

Keynoters Dean Ho and Mahendra Rao at SLAS Asia next week
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There is still time to register for the 2012 Asia Conference and Exhibition, June 19-21 in Shanghai. From nanoparticulate diamonds to lung-on-a-chip applications, each session features leading researchers sharing their latest discoveries to advance the field, and the exhibition features new technologies from 40 different international companies. More


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Company profiles updated in The SLAS Market Place
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See what is new at AssayMetrics, Biotix, Brooks Life Science Systems, BSI Systems, Cadence, ChanTest, E&K Scientific, IntelliCyt, LiCONiC Instruments US, Torrey Pines Scientific, USA Scientific and V&P Scientific. These 12 companies recently updated their SLAS online product directory profiles. More

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Biosimilar, biobetter and next generation antibody characterization by mass spectrometry
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
This feature introduces the strategies of therapeutic antibodies (mAbs) in-depth characterization by mass spectrometry (MS) and discuss analytical comparison of biosimilar to originator mAbs, with the cases of trastuzumab and cetuximab. In addition, the structural and functional insights gained both by state-of-the art and emerging MS methods used for biobetters and next generation antibodies design and optimization will also be highlighted. More

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First tabletop x-ray laser
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The world's first tabletop X-ray laser doesn't require a trip to a synchrotron facility and produces pulses fast enough to capture blindingly fast chemical processes. If commercialized as planned, the system could make it possible to carry out new types of spectroscopic and materials studies at relatively affordable costs. Potential applications include monitoring and analyzing short-timescale chemical processes such as charge, spin, light and energy interactions in advanced materials. More

Native chemical ligation of thioamide-containing peptides: Development and application to the synthesis of labeled α-synuclein for misfolding studies
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Thioamide modifications of the peptide backbone are used to perturb secondary structure, to inhibit proteolysis, as photoswitches, and as spectroscopic labels. Thus far, their incorporation has been confined to single peptides synthesized on solid phase. We have generated thioamides in C-terminal thioesters or N-terminal Cys fragments and examined their compatibility with native chemical ligation conditions. More


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New Biohit Roboline™ Liquid-Handling Automate
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Investigate major signaling pathways
Cisbio provides a panel of cellular kinase assays dedicated to the measurement of site-specific phosphorylation, in an endogenous cellular environment. These homogeneous assays represent a reliable, robust and rapid alternative to classical technologies like Western Blot, ELISA or bead-based assays.
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Alpaqua Magnet Plates... Like No Other
ALPAQUA® offers 24-well, 96-well & 384-well magnet plates with integrated spring technology for touch-off dispensing and complete supernatant removal while eliminating costly tip crashes and occlusions. Strong NdFeB magnets enable rapid, reliable bead capture and retention. Alpaqua magnet plates are SBS compliant and compatible with many liquid handlers, plate hotels & stackers.


APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice
Proceedings of the National Academy of Sciences    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Insulin resistance and defective insulin secretion are the two major features of type 2 diabetes. The adapter protein APPL1 is an obligatory molecule in regulating peripheral insulin sensitivity, but its role in insulin secretion remains elusive. Here, we show that APPL1 expression in pancreatic β cells is markedly decreased in several mouse models of obesity and diabetes. More

Japanese scientists show 'new' liver generation using hepatocyte cell transplantation
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Researchers in Japan have found that hepatocytes, cells comprising the main tissue of the liver and involved in protein synthesis and storage, can assist in tissue engineering and create a "new liver system" in mouse models when donor mouse liver hepatocytes are isolated and propagated for transplantation. More



What does a century do to a genome?
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The difference between a newborn and a nonagenarian is more than skin deep, going all the way down to their genes — or at least a particular modifier of those genes, new research finds. The study found that while people's genes remain the same, modifications to the molecular structure of the genome, what's called the epigenome, change how much protein they produce, and as a result, how cells function. More

There are a million billion x five more billion new drugs awaiting discovery
Popular Science    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Think a trip to the pharmacy is overwhelming? Try this: One million billion billion billion billion billion billion. That's a 1 with 60 zeroes after it. That's the number of potential new medicines that could still be made, according to a new study. It may be more than the number of stars in the universe. Despite decades of advances in small-molecule medicine, scientists have synthesized "barely one tenth of 1 percent" of the potential drug cocktails that could exist, Swiss researchers say. More


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MAP-C2 liquid handling workstation for cell-based assays.

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Click here for the MAP-C2 video of cell seeding and cell media exchange in Transwell® plates.


Decoding DNA finds breast tumor signatures that predict treatment response
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Decoding the DNA of patients with advanced breast cancer has allowed scientists to identify distinct cancer "signatures" that could help predict which women are most likely to benefit from estrogen-lowering therapy, while sparing others from unnecessary treatment. Researchers at Washington University School of Medicine in St. Louis uncovered mutations linked to whether or not women respond to aromatase inhibitors, drugs often prescribed to shrink large tumors before surgery. More

NIH Director Francis Collins addresses drug repurposing
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"This it the time folks. This is the 21st century biology you’ve been waiting for." Hear what else the NIH director had to say in his 2012 TEDMED presentation, which he kicked off with a song, "Disease Don't Care" with Jill Sobule. More

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Professors take big step to develop nuclear fusion power
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Imagine a world without man-made climate change, energy crunches or reliance on foreign oil. It may sound like a dream world, but University of Tennessee, Knoxville, engineers have made a giant step toward making this scenario a reality. UT researchers have successfully developed a key technology in developing an experimental reactor that can demonstrate the feasibility of fusion energy for the power grid. More

Explore the optimization of targeted DNA sequencing
Oxford Gene Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
"Fishing for variants in the deep end of the gene pool" is a new Oxford Gene Technology application note discussing how the intelligent design of custom bait probes can significantly improve data quality by decreasing off-target noise, increasing the depth of coverage and optimizing the sensitivity of variant detection. Well-designed probes can also be used to investigate GC-rich areas of the genome, thereby ensuring studies are not biased towards low-GC regions. More

Potential carbon capture role for new CO2 absorbing material
PhysOrg     Share    Share on FacebookTwitterShare on LinkedinE-mail article
A novel porous material that has unique carbon dioxide adsorption properties has been developed through research led by The University of Nottingham. The findings, published in the peer-reviewed journal Nature Materials, form part of ongoing efforts to develop new materials for gas storage applications and could have an impact in the advancement of new carbon capture products for reducing emissions from fossil fuel processes. More


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Rapid Sample Transfer Between Different Labware Formats
This application note by INTEGRA discusses and demonstrates how the advent of adjustable spacing multichannel pipettes presents labs with a valuable new tool for accelerating tasks where samples need reformatting while at the same time increasing precision, reliability and comfort of the pipetting procedure. MORE
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Get your free automation consultation
Astech Projects launch new turnkey approach to automation at SLAS! Composed of four key steps – consultation & proposal, concept design study, proof of concept, and detailed design, manufacture and testing – Astech currently offers the initial consultation & proposal free of charge. Apply for yours today.


Career


Sr. Scientist/Engineer – Laboratory Automation
BD (Becton Dickinson and Company)
USA – MD – Sparks

Mechanical Engineering Manager
Labcyte Inc.
USA – CA – Sunnyvale

Fellow – Ph.D.
Seattle Children’s Research Institute
USA – WA – Seattle

More jobs at SLAS Career Connections


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