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SLAS Europe: High-Content Screening Conference, June 27-29, Dresden, Germany
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SLAS Europe invites researchers, academics and industry professionals to explore the latest advances and emerging technologies in high-content screening. A sampling of presentation titles includes:
  • Using High-Throughput Microscopy to Study Membrane Traffic, Organelle Biogenesis and Disease Mechanisms – Rainer Pepperkok (European Molecular Biology Laboratory)
  • High-Throughput Microfluidic Platform for Culture of 3D Kidney Tissue Models – Henriëtte Lanz (Mimetas)
  • Phenotypic Drug Discovery – The Move from High-Content to High-Impact Screening
 – Lorenz Mayr (AstraZeneca)
  • High-Throughput 3D and 4D Biology to Gain Insight into the Emergence of Tumour Cell Heterogeneity – Chris Bakal (The Institute of Cancer Research)
The conference is being held at the Max Planck Institute of Molecular Cell Biology and Genetics. Register now.
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Applications for SLAS2017 Innovation AveNEW Now Being Accepted
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Each year, SLAS International Conference and Exhibition participants look forward to learning about groundbreaking new ideas from entrepreneurial companies represented on SLAS Innovation AveNEW.

With selection based on technical merit and commercial feasibility, SLAS Innovation AveNEW participant companies selected receive exhibit space, travel and hotel accommodations. The application deadline for SLAS2017 Innovation AveNEW is Oct. 14.
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New and Free at JBS Online: A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data
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Most image analysis pipelines rely on multiple channels per image with subcellular reference points for cell segmentation. Single-channel phase-contrast images are often problematic, especially for cells with unfavorable morphology, such as induced pluripotent stem cells.

The authors from King's College London, National Institute for Health Research and Farr Institute of Health Informatics Research, all in the United Kingdom, present an efficient tool set for automated high-content analysis suitable for cells with challenging morphology. They believe their validated platform will further extend its value to other cell types, including cells with different morphologies, and readily offers unique capabilities to characterize large panels of human pluripotent stem cells.
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What Makes the SLAS International Conference and Exhibition Unique?
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"The scale and cross-disciplinary diversity of the SLAS conference provides a unique opportunity to showcase your work to an extensive network of life sciences and technology professionals from across industry and academia worldwide," says Dieter Drexler, Bristol-Myers Squibb, and Melanie Leveridge, GlaxoSmithKline, track chair and associate track chair of the Advances in Bioanalytics, Biomarkers and Diagnostics Track.

Cathy Tralau-Stewart, University of California, San Francisco, and Assay Development and Screening Track chair, adds: "SLAS is a unique forum in that it effectively brings together academic and industrial expertise within the screening technology space. While other conferences do this, I think this multi-discipline mix is the key differentiator for SLAS."

Research the possibilities, and then submit your work for SLAS2017 podium presentation consideration. Abstracts are due Aug. 8.
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Beyond Problem Solving to Value Creation: Teaching Innovation and Entrepreneurship in an Academic Environment
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"The complexity and competitiveness of business today requires that technical professionals be able to identify technical challenges and develop innovative solutions that provide value in a variety of business situations. The value creation is the key component. Engineers can often efficiently solve problems but they must also be able to identify the right problems and develop solutions that provide value to the relevant stakeholders."

This quote is from a blog post of Inside Out Innovations (IOI), a business advisory firm that will conduct a half-day workshop on creating a meaningful value proposition for SLAS2017 Innovation AveNEW company representatives. More tips are available on the IOI website.
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A New Approach to Chemical Synthesis
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MIT chemists have devised a new way to synthesize a complex molecular structure that is shared by a group of fungal compounds with potential as anticancer agents. Known as communesins, these compounds have shown particular promise against leukemia cells but may be able to kill other cancer cells as well. The new synthesis strategy should enable researchers to generate large enough quantities of these compounds to run more tests of their anticancer activity. More


Personalized Medicine Study Improves Connection Between Genomic and Proteomic Variation
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers and physicians are increasingly learning that medical interventions can be more successful when they are tailored to the particular profile of the individual patient. Yet, defining that profile has proven tough, as it involves information on an individual's genome, proteins, fats, and variety of other biomolecules that constitute the individual's tissue makeup. And so far, the only differences that have been seriously taken into account are those found between genes. More


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Chemists Invent New Supercapacitor Materials
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Dr David Eisenberg and Prof. Gadi Rothenberg of the University of Amsterdam's Van 't Hoff Institute for Molecular Sciences have invented a new type of supercapacitor material with a host of potential applications in electronics, transportation and energy storage devices. The UvA has filed a patent application on this invention. Eisenberg and Rothenberg discovered the supercapacitor material during sideline experiments as part of the Fuel Cells project of the Research Priority Area Sustainable Chemistry. More


Rotamer-Restricted Fluorogenicity of the Bis-Arsenical ReAsH
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Fluorogenic dyes such as FlAsH and ReAsH are used widely to localize, monitor, and characterize proteins and their assemblies in live cells. These bis-arsenical dyes can become fluorescent when bound to a protein containing four proximal Cys thiols — a tetracysteine (Cys4) motif. Yet the mechanism by which bis-arsenicals become fluorescent upon binding a Cys4 motif is unknown, and this nescience limits more widespread application of this tool. More




Breathing Life Into Papers
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Reproducibility problems plague the scientific literature. Several recent analyses have suggested that large swaths of published work in some fields are irreproducible. Some pundits are calling for a complete overhaul of the scientific publishing process to make researchers more accountable for their methodologies and publications. One project, supported in part by a $5 million, five-year grant from the National Science Foundation, aims to take a step in that direction. More


50 Years of HPLC
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
For some chromatographers, their first inkling that high-performance liquid chromatography was going to be a big deal came in 1969. That year, they traveled to Las Vegas to attend the fifth in a series of meetings organized by University of Houston chemist Albert Zlatkis. Earlier meetings in the "Advances in Chromatography" series had focused on gas chromatography, which separates volatile compounds in a mixture as it passes through a gas-filled column. More


Chemist Unveils Latest Forensic Discovery to Identify Criminals
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First it was fingerprints. Now it's blood. Ongoing forensic research led by University at Albany assistant chemistry professor Jan Halámek and his team has revealed a simple way to estimate the age range of a culprit through blood residue left at a crime scene. By analyzing alkaline phosphatase levels, a biomarker found in all body tissues, his team can tell if the originator is young (under 18) or older, along with the time since deposition of the blood spot. More


Body's Own Gene Editing System Generates Leukemia Stem Cells
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Cancer stem cells are like zombies — even after a tumor is destroyed, they can keep coming back. These cells have an unlimited capacity to regenerate themselves, making more cancer stem cells and more tumors. Researchers at University of California San Diego School of Medicine have now unraveled how pre-leukemic white blood cell precursors become leukemia stem cells. The study used human cells to define the RNA editing enzyme ADAR1's role in leukemia, and find a way to stop it. More


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