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From the SLAS President: SLAS2015 — Get in the Game
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In the new From the SLAS President column in the SLAS Electronic Laboratory Neighborhood e-zine, Daniel G. Sipes suggests how to get the most out of your conference experience via poster and podium presentations, SLAS Innovation Awards, Tony B. Academic Travel Awards and Innovation AveNEW exhibitor opportunities.
Sipes says the SLAS Annual Conference and Exhibition is "known as THE place to launch (and discover) new scientific technologies and techniques, and THE place to build an intelligent network of friendly professionals. There's no better way to appreciate the SLAS2015 experience than from the front lines."
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JALA Special Issue Call for Manuscript Proposals: Advancing Scientific Innovation with Acoustic Drop Ejection
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Guest Editors Clive Green, Ph.D., Lynn Rasmussen and Joe Olechno, Ph.D. invite manuscript proposals by Oct. 31, 2014.
Share your work in the use of acoustic drop ejection in drug discovery and biological sciences in areas such as compound handling, secondary screening and dose-response experiments, ADME-Tox, qPCR, siRNA and combinatorial chemistry.
SLAS members and nonmembers alike are welcome to submit proposals.
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SLAS2015 Short Course Menu Now Available
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Check the list of one- and two-day SLAS2015 Short Courses currently scheduled for Feb. 7-8 in Washington, D.C.
The SLAS2015 Short Course Planning Committee — Chair Sue Holland-Crimmin, GSK; Andrew Napper, Nemours Center for Childhood Cancer Research; Burkhard Schaefer, BSSN Software; and Martin Valler, Boehringer Ingelheim Pharma — reviewed participant evaluations and re-engineered course offerings to best reflect the needs of the community.
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Congratulations Ali!
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Ali Khademhosseini, JALA Editorial Board Member and SLAS Innovation Award winner, earned a spot on the new Thomson Reuters Highly Cited Researchers list for his expertise in materials science. This list focuses on more contemporary research achievement, surveying only articles and reviews in science and social sciences journals indexed in the Web of Science Core Collection during the 11-year period 2002-2012.
Additionally, rather than using total citations as a measure of influence or impact, only Highly Cited Papers were considered. Highly Cited Papers are defined as those that rank in the top 1 percent by citations for field and year indexed in the Web of Science, which is generally but not always year of publication. These data derive from Essential Science Indicators℠ (ESI).
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SLAS LabAutopedia Video of the Month: Robotic Snake and Spider
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In Titanoboa Meets the Mondo Spider, a person rides a giant robotic spider and circles a giant robotic snake, showing unique robotic movements and controls.
This fun video is one of many informative tidbits on the SLAS scientific wiki offering a collaborative compilation of the world's laboratory technology knowledge grown and updated by an online community.
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Snapshots of Life: A Fantastic Voyage, Inside the Airport
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In his Director's Blog, SLAS2015 keynote speaker and National Institutes of Health Director Francis Collins explores "Life: Magnified," the stunning exhibit of 46 scientific images on display at Washington Dulles International Airport and online.
"Look closer. You'll find cells and other of life's tiniest parts — blood, brain, and cancer cells; bacteria, viruses, even gecko toe hairs — all magnified up to 50,000 times, using the latest microscopy techniques."
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6.2 Shipping Training is required biennially – when was the last time you trained?
All training is conducted in accordance with the regulations published by IATA, ICAO, US DOT, Transport Canada, RID/ADR and the Universal Postal Union
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The xCELLigence RTCA Cardio System monitors cardiomyocyte beating functions in a 96-well format under physiological conditions, using a noninvasive label-free impedance-based technology. Rule out both acute and long-term cardiotoxicity in a single experiment. For more information, please visit www.aceabio.com.
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Funding Boost for NIH
Inside Higher Ed Share
A U.S. Senate panel approved a budget bill that would increase funding for the National Institutes of Health by $605 million for the fiscal year that begins Oct. 1. Lawmakers on the Senate's appropriations subcommittee that oversees education, health and labor programs passed legislation that would increase the NIH's budget to nearly $30.5 billion in the coming year. That $605 million jump represents a greater increase than the $198 million increase the Obama administration had requested.
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C-C Coupling Repertoire Grows
Chemical & Engineering News Share
The revival of a nearly 50-year-old technique for forming carbon-carbon bonds may help ease the synthesis of aryl derivatives, such as drug candidates. Varinder K. Aggarwal and coworkers at the University of Bristol, in England, have taken a venerable but neglected synthesis called Zweifel olefination and made it new again. The team's approach overcomes key limitations of Suzuki-Miyaura coupling, the reaction most often used in the pharmaceutical industry for creating C–C linkages.
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NIH Report Warns of Looming Physician-Scientist Shortage
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Recently the mainstream has come to embrace the fact that the job market for Ph.D. biomedical researchers is overcrowded. According to a new report from a working group of the National Institutes of Health Advisory Committee to the Director, the job market looks very different for physician-scientists. In fact, "(t)here may not be enough (physician-scientists) to replace those preparing to retire," Jocelyn Kaiser reports in a ScienceInsider.
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Unraveling the Coupling between Demixing and Crystallization in Mixtures
Journal of the American Chemical Society Share
Using molecular simulation, we shed light on the coupling between the two nonequilibrium processes of demixing and crystallization in mixtures of fully miscible, size-matched, liquid metals. We show that the competition between these processes has a strong impact on the crystallization pathway, leading to the formation of crystal nuclei with large excesses in the component of higher cohesive energy, and resulting in increases of more than 30 percent in the free energy barrier of nucleation.
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Eliminate cardiotoxic compounds and identify potential cardiac drug candidates earlier in the drug discovery process.
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Windows Bug-Testing Software Cracks Stem Cell Programs
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Software used to keep bugs out of Microsoft Windows programs has begun shedding light on one of the big questions in modern science: how stem cells decide what type of tissue to become. Not only do the results reveal that cellular decision-making is nowhere near as complicated as expected, they also raise hopes that the software could become a key tool in regenerative medicine. "It is a sign of the convergence between carbon and silicon-based life," says Chris Mason, a regenerative medicine specialist at University College London.
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New Membrane-Synthesis Pathways in Bacteria Discovered
Bioscience Technology Share
Biologists at the Ruhr-Universität Bochum have discovered new mechanisms used by bacteria to manufacture lipids, i.e. fat molecules, for the cell membrane. Those mechanisms are a combination of familiar bacterial synthesis pathways and of such that occur in higher organisms. Thus, the team headed by Prof Dr Franz Narberhaus and Dr Roman Moser has debunked the long-standing theory that lipid production in bacteria differs substantially from that in higher organisms.
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What is Big Pharma's Core Competency?
By Mike Wokasch Share
 Specifically identifying and defining your core competency — what a company does really well and perhaps better than anyone else — is a key strategic determination for any business. Successful businesses focus resources around exploiting their core competencies to deliver value through their products or service offerings. In a mature industry like pharmaceuticals, you might think that determining a drug company's core competency would be pretty obvious. You also might think that most Big Pharma companies have this well sorted out. Well, I'm not so sure.
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Bioscavengers: New Discoveries Could Help Neutralize Chemical Weapons
Science Daily Share
Researchers at the University of Tennessee at Knoxville are a step closer to creating a prophylactic drug that would neutralize the deadly effects of the chemical weapons used in Syria and elsewhere. Jeremy Smith, UT-ORNL Governor's Chair and an expert in computational biology, is part of the team that is trying to engineer enzymes — called bioscavengers — so they work more efficiently against chemical weapons.
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Glucose Monitoring for Diabetes Made Easy With a Blood-Less Method
Phys.org Share
Treating Diabetes — a major scourge of humanity bothering millions of people — requires a constant monitoring of the human blood for glucose concentrations. While current schemes employ electrochemical methods, they require extraction of blood samples. By using glucose-sensitive dyes and a nano-plasmonic interferometer, a research team from Brown University has shown how to achieve much higher sensitivities in real-time measurements while using only saliva instead of blood.
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Mini-Retina Created with Stem Cells
Live Science Share
Scientists have created what they say is essentially a miniature human retina in a dish, using human stem cells. This development could one day lead to treatments for those with several forms of vision loss, including blindness, researchers added. The retina is the layer of cells at the back of the eyeball that helps the eye sense light and relay visual data to the brain. Many forms of vision loss result from the malfunction or death of the light-sensitive cells known as photoreceptors in the retina.
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SLAS Point-to-Point
Colby Horton, Vice President of Publishing, 469.420.2601
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