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SLAS
In a just-released SLAS Technology auto-commentary, the authors of "Peripheral Focused Ultrasound Stimulation (pFUS): New Competitor in Pharmaceutical Markets?" outline their group’s results using focused ultrasound stimulation within peripheral organs to precisely activate autonomic nerve circuits. This research, featured in Nature Communications, highlights the growing evidence that ultrasound energy could solve many of the early challenges facing the field of bioelectronic medicine. Access to this auto-commentary will be available online until August 14.
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SLAS
The SLAS Nominations Committee is accepting Board of Director candidate applications until Wednesday, July 10. Three positions will be filled with the new members taking office on January 27, 2020, during the SLAS2020 International Conference and Exhibition. This is a great opportunity to help shape the future strategic direction of the Society while working alongside a diverse and energetic group of leaders.
VIEW THE COMPLETE NOMINATION DETAILS
SLAS
Proposals are now accepted through Wednesday, July 31 for the upcoming SLAS Discovery special edition, Functional Genomics for Target Identification. Guest Editors Stuart Farrow, Ph.D. (Cancer Research UK) and Davide Gianni, Ph.D. (AstraZeneca) invite papers and research reports on a variety of topics within functional genomics screening, including the identification of novel therapeutic targets and pathways, understanding the emergence of drug resistance mechanisms, generating novel hypothesis for combination therapies and patient stratification. Don’t miss this opportunity to share your research with a global audience.
COMPLETE SUBMISSION INSTRUCTIONS
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SLAS
With SLAS Europe 2019 just around the corner, it's time to do some final prep work before arriving in Barcelona:
- Join the conversation: Follow us on Facebook, Twitter, LinkedIn and Instagram and use hashtag #SLASEurope2019 to post your own updates and thoughts on conference sessions and events.
- Not signed up yet? Full conference and short course registration are still available.
Take a closer look at the SLAS Europe 2019 program and plan your schedule around these not-to-be-missed events:
- SLAS Journal Strategy Workshop: Learn how to prepare a manuscript for submission and engage in an open strategy session with SLAS Technology Editor, Edward Kai-Hua Chow, Ph.D., and SLAS Discovery Editor, Robert M. Campbell, Ph.D.
- Walking Gala Dinner: Join fellow attendees for a night of relaxation with a walking gala dinner at the Purobeach, an urban oasis with one of Barcelona’s best sunset views.
- SLAS FUNd Run: Lace up your running shoes and enjoy a jog or brisk walk and take in breathtaking views of the sea during this non-competitive 5km or 7.5km event.
See you next week!
SLAS
While podium abstract submissions are now closed for all three SLAS topical symposia, poster abstracts are still being accepted. Research scientists, engineers, academics and business leaders are encouraged to submit while contributions from graduate students, post-doctoral associates and junior faculty are also accepted. This is a unique opportunity to present your research on a one-on-one basis with fellow subject-matter experts. Excellent sponsorship and tabletop exhibit opportunities are also available at each symposium.
SLAS 2019 AI in Process Automation Symposium – Boston, MA, USA (October 3-4)
Submission deadline: August 30
SLAS 2019 Advanced 3D Human Models and High-Content Analysis Symposium – London, UK (October 21-22)
Submission deadline: September 13
SLAS 2019 Americas Sample Management Symposium – Boston, MA, USA (November 20-21)
Submission deadline: August 27
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SLAS
SLAS Journal Special Issues Call for Papers
SLAS Discovery: Functional Genomics for Target Identification
July 31: Proposals due
October 31: Invited submissions due
Upcoming 2019 Events
SLAS Europe 2019 Conference and Exhibition
Short Courses: June 25
Full conference: June 26 - 28
Barcelona, Spain
Exhibit and sponsorship opportunities available
Save the Dates
SLAS 2019 AI in Process Automation Symposium
October 3 - 4
Boston, MA
Exhibit and Sponsorship Opportunities Available: Contact Karen Layser
SLAS 2019 Advanced 3D Human Models and High-Content Analysis Symposium
October 21 - 22
London, UK
SLAS 2019 Americas Sample Management Symposium
November 20 - 21
Boston, MA
Sponsorship Opportunities Available: Contact Karen Layser
SLAS2020 International Conference and Exhibition — Call for Abstracts Now Open
January 25 - 29, 2020
San Diego, CA
Call for Podium and Poster Abstracts Now Open
COMPLETE LIST OF SLAS CONFERENCES AND SYMPOSIA
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Analytical Chemistry
Quantitative evaluation of small molecule permeation and accumulation in Gram-negative bacteria is important for drug development against these bacteria. While these measurements are commonly performed at physiological pH, Escherichia coli and many other Enterobacteriaceae infect human gastrointestinal and urinary tracts, where they encounter different pH conditions.
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Journal of the American Chemical Society
Switches that can be actively steered by external stimuli along multiple pathways at the molecular level are the basis for next-generation responsive material systems. The operation of commonly employed molecular photoswitches revolves around one key structural coordinate. Photoswitches with functionalities that depend on and can be addressed along multiple coordinates would offer novel means to tailor and control their behavior and performance.
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Science Daily
It's a feat three decades in the making: Harvard University chemists have achieved what a new paper calls a "landmark in drug discovery" with the total synthesis of halichondrin. Known to be a potent anti-cancer agent in mouse studies, and found naturally in sea sponges — though only ever in minuscule quantities — the halichondrin class of molecule is so fiendishly complex that it had never been synthesized on a meaningful scale in the lab.
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The Scientist
The U.S. Food and Drug Administration issued a safety alert for fecal transplant procedures after two immune-compromised patients contracted drug-resistant infections, according to a statement from the agency’s website. The patients received transplants from the same donor, and one of the patients died. As a result, the agency plans to suspend clinical trials involving the procedure, The New York Times reports.
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Phys.org
Antibiotics save countless human lives — modern medicine without them is unimaginable. The largest proportion by volume of industrially produced antibiotics today are cephalosporins, structural variants of the first antibiotic, penicillin. Unfortunately, their production generates a considerable amount of waste products, some of which are questionable. In the European Journal of Organic Chemistry, scientists have now demonstrated that a newly developed, more ecological synthetic route is suitable for the production of a wide variety of cephalosporin antibiotics.
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Lab Manager
An international research team has investigated the transport mechanism of a bacterial membrane protein using an artificially produced antibody fragment. The transport proteins, called ABC exporters, are present, for instance, in the cell membranes of bacteria and in large quantities in cancer cells and are responsible for transporting small molecules out of the cells. Some transporters can pump antibiotics or chemotherapy agents out of the cells, thus rendering therapies ineffective.
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Genetic Engineering & Biotechnology News
Swallowing a drug can tilt the gut-brain axis, alleviating the symptoms of neurodegenerative diseases such as Parkinson’s. Yet the axis can resist tilting as though its orientation were maintained by hidden sources of inertia. Suspected inertial dampeners include gut microbes. Although gut microbes have been thought to metabolize and lessen the efficacy of levodopa, the primary drug treatment for Parkinson’s, the species responsible have eluded detection.
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Laboratory Equipment
Scientists in Japan have developed a way of amplifying DNA on a scale suitable for use in the emerging fields of DNA-based computing and molecular robotics. By enabling highly sensitive nucleic acid detection, their method could improve disease diagnostics and accelerate the development of biosensors, for example, for food and environmental applications.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
Senior Scientist, In Vitro Pharmacology
Pfizer Inc.
US – CT - Groton
Automation Engineer
Baylor Genetics
US – TX – Houston
Postdoctoral Position in Neuroscience
Rutgers University Brain Health Institute
US – NJ – Piscataway
Search Jobs at SLAS Career Connections
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