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SLAS
A new and free-to-access (for a limited time) SLAS Discovery review article by GlaxoSmithKline researchers in the U.K. and U.S. offers an informative guide to the established and emerging tools available for early drug discovery and screening. The article also provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics. Image courtesy of Melanie Leveridge.
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SLAS
Daniel Irimia, M.D., Ph.D., of the BioMEMS Resource Center at the Center for Engineering in Medicine, Massachusetts General Hospital (Boston, MA, USA), used his engineer's mind with his physician's knowledge to help colleagues design a large-scale microparticle-cluster array to replicate human neutrophil swarming outside the body. The array allows the study of signaling pathways and mediators during swarming. "One of the key features of the microscale array is that we can synchronize thousands of neutrophil swarms," Irimia says in a new article in the SLAS Electronic Laboratory Neighborhood (SLAS ELN).
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SLAS
Three new individuals will join the SLAS Board of Directors for three-year terms of service beginning in 2019. Candidate applications are being accepted now through Monday, July 2. All candidates must have the capacity and commitment to serve, and meet the required criteria outlined in the SLAS Board of Directors Selection Policy, the SLAS Bylaws and the SLAS Disclosure Form. The new board members will replace those completing their terms: Sabeth Verpoorte, Ph.D., from the University of Groningen (Groningen, The Netherlands), Peter Grandsard, Ph.D., Amgen (Thousand Oaks, CA, USA) and Ian Shuttler, Ph.D., Tecan Trading AG (Zurich, Switzerland).
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Because drug discovery involves scientists from multiple disciplines and often organizations, it is critical to have an efficient mechanism for researchers to collaborate and realize the collective value of their specialized knowledge, assets, and capabilities. This free white paper details the essential keys to effective collaboration.
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SLAS
Winners from 10 different countries earned SLAS Tony B. Academic Travel Awards to present their scientific achievements at 2018 SLAS Europe Conference and Exhibition, June 27-29, in Brussels, Belgium. These exceptional undergraduate students, graduate students, post-doctoral researchers and junior faculty members will receive roundtrip travel, shared hotel accommodations and full conference registration, which includes access to the scientific program, poster presentations and exhibition as well as workshops, meetings and special events. Congratulations to:
Federico Figueredo, Ph.D., UBA-CONICET, Buenos Aires, Argentina
Jared Miles, B. Pharm. (Hons), University of Queensland, Brisbane, Australia
Sergii Grebeniuk, Ph.D., KU Leuven, Flanders, Belgium
Patrick Gentry, Ph.D., University of Copenhagen, Denmark
Florian Sizaire, M.Sc., Institut de Génétique et Développement de Rennes, France
Maximilian Benz, M.Sc., Karlsruhe Institute of Technology (KIT), Bruchsal, Germany
Ruby Karsten, M.Sc., University of Groningen, The Netherlands
Chanho Chung, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Republic of Korea
Rasel A. Al-Amin, M.Sc., University of Uppsala, Sweden
Scott Warchal, B. Pharma, University of Edinburgh, United Kingdom
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BMG Labtech
Optimizing binding kinetics offers potential clinical benefits. A novel approach determines kinetic parameters such as on- and off-rates by continuous time-resolved FRET reads. This way, the PHERAstar FSX microplate reader simultaneously measures kinetics of hundreds of compounds. Prof. Steven Charlton (Nottingham University) explains how he studies kinetics of ligand-receptor binding.
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SLAS
Register now to learn more about new screening strategies for today's tough targets from Maria Webb, Ph.D., of Merck (Kenilworth, NJ, USA), at the 2018 SLAS Americas Sample Management Symposium: Managing Samples from Bench to Clinic, Nov. 13-14 (Boston, MA, USA). Armed more than 30 years' experience with Bristol-Myers Squibb, Pharmacopeia, Ligand Pharmaceuticals, Venenum Biodesign and Merck, Webb will describe technologies to identify novel chemical matter, a blend of functional and structural approaches to interrogate targets in orthogonal assays, and a diverse collection of chemical matter. Complete scientific program now online! Poster abstracts being accepted until Monday, Aug. 27. Register before Monday, Oct. 1 to save $150.
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SLAS
Automation and High-Throughput Technologies, one of 10 educational tracks of the SLAS2019 Scientific Program, focuses on the innovative use of biological or chemistry applications, tools, technologies and techniques that pertain to automated high-throughput screening, the advancement of laboratory processes or improvement of the quality and impact of experimental laboratory data. Topics in this track will include: using physiologically-relevant models in drug discovery; imaging technologies to bridge the gap between high-content and high-throughput; leveraging HTS to perform fully automated phenotypic assays; the inclusion of IoT platforms; in-house and open source automation and much more! Plan to participate: Podium abstracts for this track and others are due Monday, Aug. 6.
Students: Apply for an SLAS Tony B. Academic Travel Award when you submit your podium or poster abstract. The travel award application and podium abstract deadline is Monday, Aug. 6. The deadline for travel awards for poster abstract submissions is Monday, Sept. 24.
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Journal of the American Chemical Society
Polycyclic aromatic hydrocarbons (PAHs) attract much attention for applications to organic light-emitting diodes, field-effect transistors, and photovoltaic cells. The current synthetic approaches to PAHs involve high-temperature flash pyrolysis or complicated step-by-step organic reactions, which lead to low yields of PAHs. Herein, we report a facile and scalable synthesis of PAHs.
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Analytical Chemistry
Prostaglandins (PG) are an important class of lipid biomolecules that are essential in many biological processes, including inflammation and successful pregnancy. Despite a high bioactivity, physiological concentrations are typically low, which makes direct mass spectrometric analysis of endogenous PG species challenging. Consequently, there have not been any studies investigating PG localization to specific morphological regions in tissue sections using mass spectrometry imaging (MSI) techniques.
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Phys.org
Scripps Research scientists have solved a major problem in chemistry and drug development by using droplet-sized "miniecosystems" to quickly see if a molecule can function as a potential therapeutic.
As they report in the journal Proceedings of the National Academy of Sciences, the new method will let researchers save critical time and funding by simultaneously testing how drug candidates bind to their cellular targets and alter cell function.
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With Lab Services you choose high-quality service. With this we have honored our name for over 25 years. We solve every laboratory automation challenge accurately and quickly. Give careful answers to all your questions. Because service and support are the source of our success.
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Lab Manager
Rice University's Caleb Bashor never planned to be an inventor or do-it-yourselfer, but there was no other way to do the microbiology experiments he envisioned.
In Nature Biotechnology, Bashor and colleagues from Boston University and the Massachusetts Institute of Technology unveil eVOLVER, a system that combines the control of automated cell-culturing systems that can run continuously for months with the scale of high-throughput systems that grow dozens of cultures at once.
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Genetic Engineering & Biotechnology News
Researchers say they have mapped the gene expression of each individual brain cell during aging in the fruit fly. Their study ("A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain"), published in Cell, could lead to new insights on the workings of the brain as it ages, according to the scientists.
"The diversity of cell types and regulatory states in the brain, and how these change during aging, remains largely unknown," write the investigators.
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Bioscience Technology
Most patients with myelofibrosis, a rare chronic disorder of the hematopoietic cells of the bone marrow, benefit from drugs from the JAK2 inhibitor class: symptoms are relieved, survival extended and general quality-of-life enhanced. However, two or three years after the start of treatment, some patients develop an aggressive B-cell lymphoma. It has now been shown for the first time that JAK2 inhibitors awaken "dormant" lymphomas in the bone marrow and, hence, cancer.
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Chemical & Engineering News
A new surface chemistry technique has allowed researchers to determine the long-sought mechanisms of one of the most studied reactions in heterogeneous catalysis: the oxidation of carbon monoxide on a platinum surface.
Catalytic CO oxidation cleans up emissions from motor vehicles and industrial smokestacks. Studied for about 40 years, it is a textbook system for the experimental and theoretical understanding of heterogeneous oxidations — gaseous reactions on catalytic surfaces.
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Science Daily
A biomimetic nanosystem can deliver therapeutic proteins to selectively target cancerous tumors, according to a team of Penn State researchers. Using a protein toxin called gelonin from a plant found in the Himalayan mountains, the researchers caged the proteins in self-assembled metal-organic framework nanoparticles to protect them from the body's immune system.
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Lab Services Team Lead
LabCorp
US – VA – Chesapeake
Postdoctoral Position in Brain-Computer Interfaces
University of Geneva
Switzerland – Geneva
Sample Preparation and NMR Metabolomics Specialist Technician
University of Birmingham
UK – Birmingham
Search Jobs at SLAS Career Connections
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