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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit June 22, 2016

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New and Free at JALA Online: Automated Gravimetric Calibration to Optimize the Accuracy and Precision of TECAN Freedom EVO Liquid Handler
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HTS technologies are increasingly integrated into the formulation development process of biopharmaceuticals. The performance of liquid handling systems is dependent on the ability to deliver accurate and precise volumes of specific reagents to ensure process quality.

A collaborative team from GSK Vaccines (Belgium) and Neomed Institute (Canada) has developed an automated gravimetric calibration procedure to adjust the accuracy and evaluate the precision of the TECAN Freedom EVO liquid handling system.

Read more in JALA from authors Laurent Bessemans, Vanessa Jully, Caroline de Raikem, Mathieu Albanese, Nicolas Moniotte, Pascal Silversmet and Dominique Lemoine.
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Make Travel Plans for SLAS2017 — SLAS Can Help!
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Hotel room reservations at discounted rates can now be made for SLAS2017, Feb. 4-8 in Washington, DC. SLAS has negotiated special rates and benefits for conference attendees with two hotels adjacent to the Walter E. Washington Convention Center — the Marriott Marquis Washington, DC (SLAS2017 headquarters hotel) and the Renaissance Washington, DC Downtown.

Three airports serve Washington, DC. Reagan National Airport (DCA) is closest to the convention center and has direct Metro access. SLAS2017 participants can contact the official SLAS2017 travel agent for assistance with air and ground travel. SLAS also offers the following tips for Washington, DC visitors. Are you an SLAS2017 exhibitor? Click here for hotel and travel details.
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JBS Reports: A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine
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A new perspectives paper in the July 2016 issue of the Journal of Biomolecular Screening (JBS) reports how the University of Pittsburgh and broad-based collaborators have defined a practical strategy and platform that is being applied to therapeutic discovery and the advancement of personalized medicine.

Their Quantitative Systems Pharmacology (QSP) strategy and platform should stimulate the paradigm shift from reactive population-based medicine to proactive personalized medicine by focusing on the patients at the starting and end points.
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SLAS FIRST Team Grant Awarded
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Congratulations to Michael Scholle, vice president at Samdi Tech in Chicago and mentor for the FIRST Lego League team, the Black Ops, from southern Illinois. Black Ops team leader Jessica Wattles is grateful for the grant. "Our team met this past year as a noncompetitive 4H club, and we have spent that time learning to program NXT robots. The kids have worked incredibly hard this year. We are a first-time competing team and currently do not have an EV3 robot. The SLAS grant can help us meet our goals. Thank you!"

SLAS invites any dues-paid member working with a FIRST team to apply for a $500 team grant. It is one way SLAS supports the FIRST mission to inspire young people to be science and technology leaders by engaging them in exciting mentor-based programs that build science, engineering and technology skills that inspire innovation and foster well-rounded life capabilities including self-confidence, communication and leadership.
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Share the SLAS Story
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Do you have colleagues who could benefit from the opportunities offered by SLAS membership?

Tell them why you belong and share this link so they can learn first-hand how others have advanced their careers and enhanced their personal lives through SLAS membership.
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Does Nanomedicine Have a Delivery Problem?
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Cancer drugs don't discriminate. They kill all cells, not just the cancerous ones. So drugmakers often look for ways to minimize how much of a chemotherapy drug ends up in healthy tissue while still delivering sustained high levels to tumors. Nanomedicine offers one possible way to thread this therapeutic needle. Loading nanoparticles with drug molecules can help the compounds stay in the blood longer and accumulate in tumors instead of in healthy tissue. More


Tiny Mirror Improves Microscope Resolution for Studying Cells
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A tiny mirror could make a huge difference for scientists trying to understand what's happening in the micron-scale structures of living cells. By growing cells on the mirrors and imaging them using super-resolution microscopy, a group of scientists from universities in the United States, China and Australia have addressed a problem that has long challenged scientists: Seeing the structures of three dimensional cells with comparable resolution in each dimension. More


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Polydimethylsiloxane-Paper Hybrid Lateral Flow Assay for Highly Sensitive Point-of-Care Nucleic Acid Testing
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In nucleic acid testing (NAT), gold nanoparticle (AuNP)-based lateral flow assays (LFAs) have received significant attention due to their cost-effectiveness, rapidity, and the ability to produce a simple colorimetric readout. However, the poor sensitivity of AuNP-based LFAs limits its widespread applications. Even though various efforts have been made to improve the assay sensitivity, most methods are inappropriate for integration into LFA for sample-to-answer NAT at the point-of-care (POC), usually due to the complicated fabrication processes or incompatible chemicals used. More


CRISPR Screen Identifies Potential Drug Target for Mosquito-Borne Virus
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Flavivirus represent a medically important genus of pathological viruses that are typically transmitted through the bite from an infected arthropod (mosquito or tick). This genus includes the viruses that cause yellow fever — for which the group gets its name, as flavus means yellow in Latin — dengue, West Nile Virus, Zika, and tick-borne encephalitis. Flaviviruses are genetically comprised of single-stranded RNA and share common physical appearances such as size and symmetry. More




Global Dynamics and Exchange Kinetics of a Protein on the Surface of Nanoparticles Revealed by Relaxation-Based Solution NMR Spectroscopy
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The global motions and exchange kinetics of a model protein, ubiquitin, bound to the surface of negatively charged lipid-based nanoparticles (liposomes) are derived from combined analysis of exchange lifetime broadening arising from binding to nanoparticles of differing size. The relative contributions of residence time and rotational tumbling to the total effective correlation time of the bound protein are modulated by nanoparticle size, thereby permitting the various motional and exchange parameters to be determined. More


Tailored DNA Shifts Electrons Into the 'Fast Lane'
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
DNA molecules don't just code our genetic instructions. They also have the unique ability to conduct electricity and self-assemble into well-defined shapes, making them potential candidates for building low-cost nanoelectronic devices. A study now shows how DNA sequences can be manipulated to turn these ribbon-shaped molecules into electron "highways," allowing electricity to flow more easily through the strand. More


Treating Cancer with CRISPR?
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers at the University of Pennsylvania are hoping to use the CRISPR gene-editing technology to modify T cells isolated from cancer patients before reinjecting the cells as a form of immunotherapy, according to a blog post by Carrie Wolinetz, associate director for science policy at the National Institutes of Health. Specifically, the Penn team aims to edit two T-cell genes: PD-1, which suppresses the cells' attack on tumors, and a receptor that can boost the immune system's ability to fight the cancer. More


Super-Resolution Microscopy Reveals Unprecedented Detail of Immune Cells' Surface
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
When the body is fighting an invading pathogen, white blood cells — including T cells — must respond. Now, Salk Institute researchers have imaged how vital receptors on the surface of T cells bundle together when activated. This study, the first to visualize this process in lymph nodes, could help scientists better understand how to turn up or down the immune system's activity to treat autoimmune diseases, infections or even cancer. More


Career


Research Chemist
Michelman
US – OH – Cincinnati

Clinical Research Associate II
St. Jude Medical
US – CA – Sylmar

Automation Engineer
New York Genome Center
US – NY – New York

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