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Strategic Pivot — The Latest Podcast from New Matter: Inside the Minds of SLAS Scientists
Severine Tamas-Lhoustou (Novoptim) chats with Scientific Director Mike Tarselli about her unique introduction to SLAS through the New Product Award, how new businesses are coping with COVID-19 and how she believes a strong scientific core is key to any successful venture.
LISTEN NOW
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July's SLAS Discovery Features Three Significant Research Areas on the 'Functional Genomics for Target Identification'
SLAS
The July special issue of SLAS Discovery, “Functional Genomics for Target Identification,” features ten articles focused on three strategic pillars that form the foundation of the functional genomics discipline. Special issue editors Davide Gianni, Ph.D., (AstraZeneca, United Kingdom) and Stuart Farrow, Ph.D., (CRUK Therapeutic Discovery Laboratories, United Kingdom) selected research reviews and articles that cover a variety of relevant topics and as a bonus four of the included articles are available via open access:
- Secretome-Based Screening in Target Discovery
- The New Frontier of Functional Genomics: From Chromatin Architecture and Noncoding RNAs to Therapeutic Targets
- A Whole Genome-Wide Arrayed CRISPR Screen in Primary Organ Fibroblasts to Identify Regulators of Kidney Fibrosis
- Arrayed CRISPR Screening Identifies Novel Targets That Enhance the Productive Delivery of mRNA by MC3-Based Lipid Nanoparticles
ACCESS JULY'S SLAS DISCOVERY
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SLAS Short Course Expansion
SLAS
SLAS is currently looking for content creators and course instructors to help build and teach new short courses. SLAS plans to expand short course offerings at our topical symposia and strategic partner events, as well as deliver them at institutions looking to expand their employee learning opportunities. Future course topics will include:
- Single-cell analysis
- Gene editing – tools, methods and applications
- All things 'omics: transcriptomics, genomics, proteomics, metabolomics
- Protein degradation as a therapeutic strategy
- Artificial intelligence, machine learning and neural networks ("AI 101")
- Scripting languages and informatics (i.e. Python toolkits)
- High-content screening and assay development
Interested? Submit a proposal including course title, expected learning guidelines, and description of why the content is relevant to the SLAS community along with an abstract and credentials (CV, LinkedIn profile) for consideration.
SLAS SHORT COURSE SUBMISSION INSTRUCTIONS
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The coronavirus (COVID-19) is a rapidly evolving threat, and the synthetic DNA that can help discover a vaccine and treatment is needed now — not in eight to ten weeks. SGI-DNA is supporting front-line researchers in combating the spread of COVID-19 by offering $50,000 in co-funding for the BioXp™ 3200 system.
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Promoted by
Thermo Scientific
The Thermo Scientific™ Orbitor™ RS2 microplate mover is a collaborative bench-top mover that provides unbeatable reliability and improved process efficiency. It’s innovative bi-directional telescoping arm coupled with it’s expansive 360° workspace provide exceptional reach and precision, making the Orbitor RS2 your trusted laboratory productivity partner.
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Calendar of Important Dates
SLAS
Additional SLAS Journals Call for Papers
Applications of Biophysics in Early Drug Discovery
SLAS Discovery
Submission topics: Developing biophysical methods, biophysical screening and characterization and related analyses and interpretation of biophysical results.
Submission deadline: July 15
SLAS Events
SLAS Events Outlook
SLAS is committed to providing a safe meeting space, high-quality education and meaningful networking opportunities for all attendees, whether in person or on a virtual platform, as circumstances warrant. We look forward to convening in person but will do so only if we can provide a safe and appropriate meeting venue as well as suitable accommodations for travelers. The SLAS team is monitoring all aspects of event logistics and solidifying plans to enable alternative forms of knowledge sharing.
Save the Date
SLAS 2020 AI Meets Sample Management Symposium
Boston, MA, USA
November 4 – 5, 2020
SLAS 2020 Building Biology in 3D Symposium
Scripps Research, Jupiter, FL, USA
November 17 – 18, 2020
COMPLETE LIST OF SLAS CONFERENCES AND SYMPOSIA
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COVID-19 Breakthrough: Steroid Dexamethasone Saves Lives
Genetic Engineering & Biotechnology News
Finally, there is some much-needed COVID-19 good news. A large trial has found that dexamethasone, a cheap and widely available steroid, decreased the risk of death in COVID-19 patients. Dexamethasone is on the shelf, available, and cheap. These preliminary results, which have not been peer-reviewed, suggest the drug should become standard care in COVID-19 severe patients.
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Studies Report Rapid Loss of COVID-19 Antibodies
The Scientist
A pair of studies is shedding light on the duration of immunity following COVID-19, showing patients lose their IgG antibodies — the virus-specific, slower-forming antibodies associated with long-term immunity — within weeks or months after recovery. With COVID-19, most people who become infected do produce antibodies, and even small amounts can still neutralize the virus in vitro, according to earlier work.
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Evotec’s broad range of sample management capabilities in drug discovery and
 bioanalysis, many years of experience and continued investments in innovation and technology enable us to meet all customers’ needs and deadlines. Find out how the expertise of a global leader in sample management can help your projects.
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Redox Switchable Polydopamine-Modified AFM-SECM Probes: A Probe for Electrochemical Force Spectroscopy
Analytical Chemistry
Polydopamine has high potential in biorelevant applications as a versatile thin film material, e.g., as adhesive coating for cell immobilization or for sensing applications due to the plethora of functional groups. In this study we present the modification of conductive colloidal atomic force — scanning electrochemical microscopy probes with electrochemically deposited PDA resulting in functional probes for quantitative electrochemical adhesion studies.
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Study Doubles Number of Experimentally Detected Proteins
Chemical & Engineering News
Many proteins for which there is no experimental evidence have been predicted from the genomes of various species. Researchers have now doubled the number of experimentally detected proteins. Matthias Mann of the Max Planck Institute of Biochemistry and the University of Copenhagen and coworkers now report their proteomic analysis of 100 species, the largest cross-species comparative proteomics study to date. They analyzed the proteomes of 19 single-celled organisms known as archaea, 49 bacteria, and 32 eukaryotes, including many well-studied model organisms.
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A Fresh Twist in Chiral Topology
Science Daily
The concept of chirality is well-established in science: when an object cannot be superimposed on its mirror image, both the object and its mirror image are called chiral. In drug industry, for instance, more than 50% of the pharmaceutically active molecules used nowadays are chiral molecules. While one of the "enantiomers" is life-saving, its counterpart with opposite handedness may be poisonous.
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Researchers Glean Insights Into How Enzymes Achieve Specific Reactions
Phys.org
Catalytic dioxygen activation and selective oxidative cleavage of C–C bonds have become the research hotspots in the field of chemistry due to their great application value in organic synthesis and industrial production.
Quercetin 2,4-dioxygenases, as a typical metalloenzymein biological system, can efficiently activate dioxygen and selectively catalyze C–C bond oxidative cleavage of organic flavonol substrates under mild conditions.
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Teleportation May Be Possible Between Electrons, Research Finds
Lab Manager
"Beam me up" is one of the most famous catchphrases from the Star Trek series. It is the command issued when a character wishes to teleport from a remote location back to the Starship Enterprise.
While human teleportation exists only in science fiction, teleportation is possible in the subatomic world of quantum mechanics — albeit not in the way typically depicted on TV. In the quantum world, teleportation involves the transportation of information, rather than the transportation of matter.
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European Physicists Boldly Take Small Step Toward 100-Kilometer-Long Atom Smasher
Science Magazine
It is a truth universally acknowledged that a physics laboratory with a world-leading scientific facility must have a plan for an even better machine to succeed it. So it is with the European particle physics laboratory, CERN, near Geneva, which is home to the world’s biggest atom smasher, the 27-kilometer-long Large Hadron Collider. CERN’s governing council announced it will launch a technical and financial feasibility study to build an even bigger collider 80 to 100 kilometers long (actually two of them in succession) that could ultimately reach an energy seven times higher than the LHC.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
Postdoc Research Associate in Bioinformatics/Computational Biology
University of Virginia
US – VA – Charlottesville
Research Technologist 3 - Dr. Laimin's Lab
Northwestern University
US – IL – Evanston
Postdoctoral Scholar in Glassy-winged Sharpshooter Genetics
University of California, Riverside
US – CA – Riverside
Search Jobs at SLAS Career Connections
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