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SLAS
A new and free-to-access SLAS Technology article aids in the discovery and understanding of long noncoding RNA (lncRNA) biology. This newly published work features the technological platforms and methodology presently used to identify lncRNA roles in biology, highlights the databases and tools used to study it, and the techniques used to study its function.
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SLAS
Following a successful call for volunteers, SLAS President Sabeth Verpoorte, Ph.D., shares her enthusiasm and excitement for those who responded and who will become actively engaged in the Society. "My sincere thanks to each and every SLAS volunteer, and my hope is you receive benefits from volunteering that far exceed the time you invest," says Verpoorte in a new column in SLAS Electronic Laboratory Neighborhood.
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SLAS
The July issue of SLAS Discovery features a review article that explains how fragment-based lead discovery (FBLD) works and illustrates its advantages over conventional high-throughput screening (HTS). Authors Bas Lamoree and Roderick E. Hubbard of the University of York (UK) illustrate how FBLD increases the chances of finding hit compounds; how its methods can deliver hits without the massive investment required for HTS; and how by starting small, FBLD gives medicinal chemists more opportunities to build more drug-like compounds. The article is free-to-access (for a limited time).
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Because drug discovery involves scientists from multiple disciplines and often organizations, it is critical to have an efficient mechanism for researchers to collaborate and realize the collective value of their specialized knowledge, assets, and capabilities. This free white paper details the essential keys to effective collaboration.
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SLAS
Register now and explore Advances in Imaging and Analysis at the 2018 SLAS Advanced 3D Human Models and High-Content Analysis Conference, Oct. 17-19, Leiden, Netherlands. This slice of the scientific program searches the constantly evolving possibilities for imaging biological samples. Join Paul French, Ph.D., of Imperial College London (UK); Peter Horvath, Ph.D., of Biological Research Centre of the Hungarian Academy of Sciences (Szeged, Hungary); and Yannis Kalaidzidis, Ph.D., of Moscow State University (Russia), as they discuss current and near-future techniques. Complete scientific program now online. Register before July 31: SLAS Premier Members save €80!
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BMG Labtech
Optimizing binding kinetics offers potential clinical benefits. A novel approach determines kinetic parameters such as on- and off-rates by continuous time-resolved FRET reads. This way, the PHERAstar FSX microplate reader simultaneously measures kinetics of hundreds of compounds. Prof. Steven Charlton (Nottingham University) explains how he studies kinetics of ligand-receptor binding.
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SLAS
SLAS selected Kelci Schilly, a graduate research assistant in the Department of Chemistry at the University of Kansas (KU, Lawrence, KS, USA), as the inaugural recipient of the 2018 SLAS Visiting Graduate Researcher Grant. The SLAS grant will provide a stipend to cover Schilly's expenses to visit the laboratory of SLAS President Sabeth Verpoorte, Ph.D., at the University of Groningen (The Netherlands) to further Schilly's research in paper-based microfluidics and peptide labeling for mass spectrometric detection. Schilly works in the KU laboratory of Susan Lunte, Ph.D.
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SLAS
Biologics Discovery, one of 10 educational tracks of the SLAS2019 Scientific Program, places emphasis on innovative solutions to increase the breadth, depth and impact of early stage efforts to fuel the biologics pipeline. Session speakers will focus on specialized approaches to develop biologic therapeutics for complex targets — including B- and T-cell cloning techniques; high-throughput miniaturized screening platforms; and phenotypic and other novel screens and methods to deorphanize hits. Gain more exposure for your research: Podium abstracts for consideration to this track and others are due Monday, Aug. 6. Students: Apply for an SLAS Tony B. Academic Travel Award when you submit your podium or poster abstract. The travel award application and podium abstract deadline is Monday, Aug. 6. The deadline for travel awards for poster abstract submissions is Monday, Sept. 24.
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SLAS
By now participants at the 2018 SLAS Europe Conference and Exhibition in Brussels, Belgium, are enjoying a lively welcome reception in the Exhibition. Today's events included opening keynote speaker Mathias Uhlén, Ph.D., of the KTH Royal Institute of Technology (Stockholm, Sweden), the opening of the Exhibition, vendor workshops, SLAS Special Interest Group (SIGs) meetings, poster presentations and 15 educational presentations reporting innovations in life sciences research.
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Chemical & Engineering News
Donald Ingber — founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard University — remembers the first time he heard of an organ on a chip. He was at a meeting, and a former postdoc he comentored with George Whitesides, Shuichi Takayama at the University of Michigan, presented something called a "lung on a chip." The chip had channels with branches the size of small airways.
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Lab Services is excited to meet you and tell you about our innovations in Laboratory integration. Visit booth #510 and discover the solutions we can offer to automate standardized processes in your laboratory. Meet us from the 27th until the 29th of June at SLAS Europe in Brussels.
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Journal of the American Chemical Society
The amino acid serine has long been known to form a protonated "magic-number" cluster containing eight monomer units that shows an unusually high abundance in mass spectra and has a remarkable homochiral preference. Despite many experimental and theoretical studies, there is no consensus on a Ser8H+ structure that is in agreement with all experimental observations.
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Science Daily
Princeton chemists have found a way to make a naturally occurring enzyme take on a new, artificial role, which has significant implications for modern chemistry, including pharmaceutical production. Their work appears in the journal Nature Chemistry.
"We have found a completely new way to get enzymes to do a non-natural reaction," said Todd Hyster, an assistant professor of chemistry.
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Lab Manager
Combinations of cancer drugs can be quickly and cheaply tested on tumor cells using a novel device developed by EMBL scientists. The research, reported in Nature Communications, marks the latest advancement in the field of personalized medicine.
Using a microfluidic device that fits in the palm of your hand, scientists screened more than 1,100 treatment conditions (56 drug combinations x 20 replicates) on patient tumor cells.
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Genetic Engineering & Biotechnology News
It's been the holy grail of drug delivery: a pill that can preserve the structural integrity of large, delicate proteins and peptides while carrying them past one forbidding barrier after another — the gastric acids of the gut, the protein-degrading enzymes of the intestine, the mucus layer of the intestine, and the tight junctions between the cells of the intestinal wall. Such a pill may soon be within the grasp of people with type 1 diabetes.
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Phys.org
By definition, antibiotics kill bacteria. Nevertheless, TU Delft researchers have succeeded in engineering bacteria to produce promising amounts of a simple carbapenem antibiotic. Carbapenem antibiotics are effective against many bacteria and are usually only used when other antibiotics fail. They are currently only produced synthetically — an expensive process that also leads to chemical waste.
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Bioscience Technology
Scientists at the Ovarian Cancer Action Research Centre at Imperial College London have discovered a mechanism that deactivates ovarian cancer cells.
The findings, published in EMBO Reports, could lead to better treatments for women with ovarian cancer.
The research has found a new mechanism for a protein named OPCML. This protein is known as a tumor suppressor, as it prevents cells turning cancerous.
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The Scientist
The brains of Alzheimer's disease patients have an abnormal build up of amyloid-β proteins and tau tangles, which, according to many researchers, drives the ultimately fatal cognitive disease. This theory is being challenged by a newer one, which posits that microbes may trigger Alzheimer's pathology.
Two new studies, using different approaches, further bolster this pathogen theory.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship, or post-doc opportunity. SLAS Premier members get a discount on all new job postings.
Lab Instructor, School of Neuroscience
Virginia Tech
US – VA – Blacksburg
Medical Laboratory Scientist (MLS)
Fairbanks Memorial Hospital
US – AK – Fairbanks
Director, Clinical Research – Oncology
Eisai Inc.
US – NJ – Woodcliff Lake
Search Jobs at SLAS Career Connections
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