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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit June 28, 2017

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PubChem BioAssay: A Decade's Development toward Open High-Throughput Screening Data Sharing
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A new, open access perspective paper in the July 2017 issue of SLAS Discovery provides an overview of the high-throughput screening (HTS) data available in the U.S. National Library of Medicine (NLM) PubChem BioAssay database and the progress of data deposition to stimulate knowledge, discovery and data-sharing.

Authors Yanli Wang, Tiejun Cheng and Stephen H. Bryant of the NLM National Center for Biotechnology Information report that with 12 years of development and the community's support, including utilizing the resource, sharing research data and providing annotations, PubChem has become a widely used public information platform supporting drug development, research for medicinal chemistry, chemical and functional genomics, and bioinformatics and cheminformatics.
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SLAS2018 Hotels Now Accepting Reservations
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SLAS has secured discount rates at both the Marriott Marquis San Diego Marina and Hilton San Diego Bayfront for SLAS2018, Feb. 3-7. Both hotels are adjacent to the San Diego Convention Center, where SLAS2018 will be held.

The Marriott rate is $273/night plus taxes; the Hilton is $272/night plus taxes. Both negotiated rates include complimentary guest room Internet. Visit the SLAS2018 website for links to hotel reservation pages and additional travel information. Act soon as official hotels historically fill up fast.
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Phenotypic Personalized Medicine, 3D Cell Culture, Courageous Young Minds & More
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For SLAS members, there's no such thing as business as usual. Staying a step ahead of today's rapidly changing scientific trends and technology is often what it takes to break new ground. From 3-D cell culture to microfluidic vortex technology to cancer cell metabolism to phenotypic personalized medicine, individual members are pioneering scientific excellence.

Visit the SLAS Electronic Laboratory Neighborhood e-zine every week to compare notes and see what's new.
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Jennifer Lippincott-Schwartz: In the Flow
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The Howard Hughes Medical Institute (HHMI) published a profile on its investigator, organelle expert and SLAS2017 keynote presenter Jennifer Lippincott-Schwartz, group leader at the HHMI Janelia Research Campus.

"Lippincott-Schwartz's methods are disarmingly easy to describe: to tackle stubborn problems, try to develop new technology to spy on the inner workings of living cells in higher resolution – both temporal and spatial — and then use those observations to answer questions about biological processes that seem so fundamental it feels ludicrous that we're just solving them now. Her work is likely to inform discoveries for decades or centuries to come," says the article.

All are invited to view Lippincott-Schwartz's SLAS2017 presentation.
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SLAS Journals: Your Gateway to Mission-Critical Information
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The SLAS journals began 2017 with new names and all new online functionality. Visit SLAS Discovery and SLAS Technology online, login or register as a new user, then browse 22 years of rigorously peer-reviewed scientific reports.

Search by author, keyword or title. Save search results for future reference, and sign up for eAlerts to keep up to date with new papers published ahead-of-print and/or with keywords that are important to you. Stay signed in for fast and easy ongoing access.
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Biologics Discovery at SLAS2018: Timely New Track
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The success of biologic therapeutics in the clinic has put greater emphasis on earlier stage efforts to increase efficiency, productivity and innovation. This SLAS2018 track emphasizes innovative solutions to increase the breadth, depth and impact of early stage efforts to fuel the biologics pipeline. It also explores how automation and screening can play a key role in the progression of new therapeutics as well as the impact of novel assays, microfluidics and biorepositories.

Track chairs are Daniel Sipes, of the Genomics Institute of the Novartis Research Foundation and Rob Howes of AstraZeneca. For more information about this track and nine others, visit the SLAS2018 website. Podium abstract submissions are being accepted until Aug. 7.
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Plasmonic Photothermal Gold Bipyramid Nanoreactors for Ultrafast Real-Time Bioassays
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Nucleic acid amplification techniques have been among the most powerful tools for biological and biomedical research, and the vast majority of the bioassays rely on thermocycling that uses time-consuming and expensive Peltier-block heating. Here, we introduce a plasmonic photothermal method for quantitative real-time PCR, using gold bipyramids and light to achieve ultrafast thermocycling. Moreover, we successfully extend our photothermal system to other biological assays, such as isothermal nucleic acid amplification and restriction enzyme digestion. More


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Custom-Built Molecule Shows Promise as Anti-Cancer Therapy
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists at the University of Bath funded by Cancer Research U.K. have custom-built a molecule which stops breast cancer cells from multiplying in laboratory trials, and hope it will eventually lead to a treatment for the disease. But perhaps even more importantly the method they used to create the molecule has potential to be applied to develop new treatments for a wide range of cancers and other diseases. More


From Strands to Droplets: New Insights into DNA Control
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A host of proteins and other molecules sit on the strands of our DNA, controlling which genes are read out and used by cells and which remain silent. This aggregation of genetic material and controlling molecules, called chromatin, makes up the chromosomes in our cell nuclei; its control over which genes are expressed ­— or not ­— is what determines the difference between a skin cell and a neuron, and often between a healthy cell and a cancerous one. More




Whole-Genome Study Shows IGF1R Inhibitors May Help Some Osteosarcoma Patients
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers report in Nature Communications ("Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma") that a genetic sequencing study has revealed that some patients with osteosarcoma could be helped by an existing drug. The team, from the Wellcome Trust Sanger Institute, University College London Cancer Institute, and the Royal National Orthopedic Hospital NHS Trust, that 10% of patients with a genetic mutation in particular growth-factor-signaling genes may benefit from IGF1R inhibitors. More


The Rise of Giant Viruses
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The number of microbes in, on and around the planet is said to outnumber the stars in the sky. The number of viruses found worldwide is at least an order of magnitude greater. As their name suggests, giant viruses are larger than many bacterial and eukaryotic cells. They were first discovered in 2003, and the true breadth of their diversity remains unknown. In a study led by researchers at the U.S. Department of Energy Joint Genome Institute, a DOE Office of Science user facility, a new group of giant viruses has been uncovered after sifting through complex genetic datasets. More


Study Sheds Light on How Bacterial Organelles Assemble
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists are providing the clearest view yet of an intact bacterial microcompartment, revealing at atomic-level resolution the structure and assembly of the organelle's protein shell. The work, led by scientists at the Department of Energy's Lawrence Berkeley National Laboratory and Michigan State University, will appear in the journal Science. They studied the organelle shell of an ocean-dwelling slime bacteria called Haliangium ochraceum. More


Selfish Yeast Genes Encode Both Toxin and Antidote
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists have discovered that wtf4, a gene from the yeast Schizosaccharomyces kambucha, boosts its odds of being passed down by encoding both a poison and an antidote, according to a study published in eLife. In a 2014 study, Sarah Zanders, a geneticist at the Stowers Institute for Medical Research in Kansas City, and colleagues discovered that in two yeast species, S. pombe and S. kambucha, meiotic drivers — genes that boost their chances of survival by interfering with meiosis — could cause infertility. More


Polymer Network Captures Drinking Water Contaminant
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Long-chain perfluorinated chemicals contaminate millions of Americans' drinking water. These compounds are a legacy of industrial pollution and the use of firefighting foam at military bases and airports; they persist in the environment because of their strong carbon-fluorine bonds. Now scientists have designed a cross-linked polymer that might more effectively remove one of the more prevalent and harmful of these compounds, perfluorooctanoic acid. More


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Senior Biochemical Automation Workflow Engineer
Agilent Technologies
US – CA – Santa Clara

Director, Technical Services
Sonoco Products Co.
US – SC – Hartsville

Scientific Manager/Group Leader, Biologics Sample Management – Early Research and Development
Genentech
US – CA – South San Francisco

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