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New Liquid Handling Short Course at SLAS2015
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 "Liquid Handling Essentials — A Hands-on Workshop Bridging Fundamental Concepts to Practice" will be held Saturday, Feb. 7. This SLAS2015 Short Course, one of seven new or re-engineered courses, is designed with the new and experienced liquid handling user in mind. With a balanced mix of lecture and hands-on instruction, the course focuses on understanding and applying key liquid handling concepts while measuring the outcome on live systems. Best practices and guidance for assessing and maintaining quality pipetting performance are emphasized.
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New at JBS Online: The Use of Antibodies in Small-Molecule Drug Discovery
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 Catherine J. Marsden, Ph.D., and her AstraZeneca team from Macclesfield, Cheshire, UK, summarize the application of antibodies and other protein affinity reagents as specific research tools within the drug discovery process. Marsden's is the cover article in the July issue of JBS, which now is online for members and subscribers. Other highlights include original research manuscripts on "A Single-Chain Antibody Using LoxP511 as the Linker Enables Large-Content Phage Library Construction via Cre/LoxP Recombination," "CXCR4 Antagonists: A Screening Strategy for Identification of Functionally Selective Ligands" and "Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy."
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SLAS ELN Reports: Small Molecule Profiling — Dealing with the Data
SLAS Share
 "Although high-throughput screening has been going on for almost two decades, only now are substantial public datasets emerging and being made available for cross analysis — and they're large enough and well annotated enough to make a difference in our work," says Paul Clemons, Ph.D., director, Computational Chemical Biology Research at the Broad Institute. Clemons, along with Darren Green, Ph.D., are guest editors of the recent JBS Special Issue on Knowledge from Small-Molecule Screening and Profiling Data. Read more about the exciting work published in this arena in the SLAS Electronic Laboratory Neighborhood e-zine feature article.
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Increased Convenience for JALA & JBS Authors
SLAS Share
 The JALA and JBS SAGEtrack manuscript submission systems now offer authors two important new features. In addition to the time- and effort-saving FastPass submission shortcut introduced earlier this year for EndNote users, the systems now interact with ORCid. The ORCid Open Researcher and Contributor ID initiative allows users to create permanent, unique ORCid records that may be linked to contact information, institutional affiliations, publication records and other identifiers. JALA and JBS SAGEtrack now give authors the ability to use and directly access their ORCid IDs.
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SLAS Asia Seminar Draws 150 Participants
SLAS Share
 "Establishing Cell-based Assay for Screening" in Shanghai on June 27 featured scientific presentations, question-and-answer time and networking. The seminar was co-hosted by Shanghai Tech University and sponsored by Beckman Coulter Life Sciences. Speakers were Wei Deng, National Center for Protein Science, "High-Throughput Protein Expression and Cell-based Assay"; Jianfeng Liu, Huazhong University of Science and Technology and Key Laboratory of Molecular Biophysics, "Cell-based Functional Assay for GPCR"; Yuanfeng Xia, HD Biosciences, "Cell-based Assays for Drug Discovery and Screening." Photos are on Facebook.
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6.2 Shipping Training is required biennially – when was the last time you trained?
All training is conducted in accordance with the regulations published by IATA, ICAO, US DOT, Transport Canada, RID/ADR and the Universal Postal Union
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Chemist Builds Device to Measure Chemical Warfare Agent Effects on Surfaces
Phys.org Share
For the last five years, the research group in the laboratory of John Morris, professor of analytical chemistry, has been doing something no group has done before — they have engineered, designed and built an instrument, the size of which fills an entire laboratory, to study how chemical warfare agents react on surfaces.
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New Technology Traces Entire Life of a Cell
Genetic Engineering & Biotechnology News Share
Scientists have developed a novel technique to trace the life history of individual cells back to their origins in a fertilized egg. By looking at the copy of the human genome present in healthy cells, they say they were able to build a picture of each cell's development from the early embryo on its journey to become part of an adult organ.
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Noninvasive Brain Control: New Light-Sensitive Protein Enables Simpler, More Powerful Optogenetics
Science Daily Share
Optogenetics, a technology that allows scientists to control brain activity by shining light on neurons, relies on light-sensitive proteins that can suppress or stimulate electrical signals within cells. This technique requires a light source to be implanted in the brain, where it can reach the cells to be controlled. MIT engineers have now developed the first light-sensitive molecule that enables neurons to be silenced noninvasively, using a light source outside the skull.
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Multispan, Inc. Share
GPCRs are one of the most pharmacologically successful drug targets with 26% of all drugs against this class1. GPCR-targeted therapeutics continues to be successful and in fact, 19% of newly approved drugs target GPCRs. The early generation of small molecule drugs targeted either orthosteric agonist or antagonist activity of these receptors’ G-protein signaling pathway. In recent years, we have discovered more about GPCRs including crystal structures, improvements in ligand design, differences in the signaling pathways and as well as how these receptors dimerize.
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Specialized Microbes Clean Stubborn Chemicals from the Environment
Science 2.0 Share
Chlorinated chemicals perform a host of societally useful functions, but they're not perfect. Once their use life has ended, they can become environmental contaminants and even resistant to bioremediation. In a series of new studies, Anca Delgado, a researcher at Arizona State University's Biodesign Institute, examines unique groups of microorganisms, capable of converting hazardous chlorinated chemicals like trichloroetheene (TCE) into ethene, a benign end product of microbial biodegradation.
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Eliminate cardiotoxic compounds and identify potential cardiac drug candidates earlier in the drug discovery process.
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It May Take 'Guts' to Cure Diabetes
Bioscience Technology Share
By switching off a single gene, scientists at Columbia University's Naomi Berrie Diabetes Center have converted human gastrointestinal cells into insulin-producing cells, demonstrating in principle that a drug could retrain cells inside a person's GI tract to produce insulin.
The new research was reported in the online issue of the journal Nature Communications.
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Tough Tungsten Alloy Produces Purer Nanotubes
Chemistry World Share
Researchers in China have taken a major step towards overcoming one of the main hurdles that is hampering the exploitation of carbon nanotubes for many high-tech applications — how to synthesise chirally pure samples. The chirality of a single walled carbon nanotube is defined by the diameter of the tube (n) and the wrapping angle, or twist (m), expressed as the index (n,m). Slight changes in these parameters can lead to markedly different properties, so being able to produce a single chirality on demand would represent a major step forward. So far, however, this has proved challenging.
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Rare Mutations May Highlight Promising Heart Disease Target
Drug Discovery News Share
Coronary artery disease is the most common form of heart disease, coming in as the No. 1 cause of death in the U.S. and a leading cause of death worldwide. Three types of fat that circulate in the bloodstream— low-density lipoproteins (LDL cholesterol), high-density lipoproteins (HDL cholesterol) and triglycerides—are known to affect an individual's risk of heart disease.
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A Breakthrough for Organic Reactions in Water
Lab Manager Share
Green-chemistry researchers at McGill University have discovered a way to use water as a solvent in one of the reactions most widely used to synthesize chemical products and pharmaceuticals. The findings, published June 26 in Nature Communications, mark a potential milestone in efforts to develop organic reactions in water.
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A CRISPR Way To Fix Faulty Genes
NPR Share
Scientists from many areas of biology are flocking to a technique that allows them to work inside cells, making changes in specific genes far faster — and for far less money — than ever before. "It's really powerful; it's a really exciting development," says of Craig Mello the University of Massachusetts Medical School. He won the Nobel Prize in 2006 for a different technique that also lets scientists modify how genes work. But, Mello says, this new genetic tool — known as CRISPR for clustered regularly interspersed short palindromic repeats — is more powerful, "because now you can essentially change a genome at will to almost anything you want. The sky's the limit."
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ChromaTrap Helps Advance Research into Women`s Reproductive Health
Porvair Sciences Ltd. Share
A video interview with Professor Steve Conlan of the College of Medicine at Swansea University in the UK highlights the latest research developments in women's reproductive health using unique molecular biology tools. Developed by Conlan in conjunction with Porvair Sciences, the Chromatrap solid state ChIP assay enables more tissue biopsies to be profiled for epigenetic landscape in less time and with greater efficiency than previously possible. Conlan explains the aims of his group's work towards regenerative and personalized medicine therapies for the treatment of common gynaecological conditions such as ovarian and endometrial cancers.
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SLAS Point-to-Point
Colby Horton, Vice President of Publishing, 469.420.2601
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