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Offers the fastest turnaround, highest quality and most diverse GPCR assay panel.
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Certified UPS’s to protect your laboratory’s critical instrumentation and resolve current and potential power issues.
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The SLAS Innovation Award recognizes the work behind that one unique and special presentation at SLAS2013.
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Students, graduate students, post-doctoral associates and junior faculty may apply for travel awards. Close to 40 awarded last year.
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SLAS ELN: Mobile technology charts new directions
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Mobile technology is beginning to transform not only the way companies manage their compound screening and profiling systems, but the entire healthcare landscape from drug discovery to patient care. Turning familiar devices such as cell phones and video game consoles into platforms for data collection and point-of-care analysis, these advances promise to improve disease detection and diagnosis, as well as healthcare delivery. A new SLAS Electronic Laboratory Neighborhood feature explores the challenges and opportunities for innovation.
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2012 SLAS Asia Conference registrant wins SLAS2013 prize package!
SLAS Share
Xiaotao Wang, senior scientist, AstraZeneca, Shanghai, is the winner of an SLAS2013 prize package, including roundtrip airfare to/from Orlando, Fla., USA, up to four nights hotel accommodations and a full conference registration. Wang's name was pulled randomly from all 2012 SLAS Asia Conference and Exhibition full conference paid participants.
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Aug. 31 deadline: 2013 JALA & JBS Art of Science Contest
SLAS Share
Creating great images is just one more way scientists share information resulting from their great work. Will your visual take first place in the 2013 JALA & JBS Art of Science Contest and win The New iPad? Fall just short and win one of 10 honorable mention $50 Amazon gift cards? You won't know unless you enter the contest.
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New LabAutopedia Book of the Month
SLAS Share
Mark Bowden tells the story of the experts who united to combat the Conficker worm, first detected late in 2008, which infected millions of computers including government, business and home computers. Bowden is the bestselling author of Black Hawk Down: A Story of Modern War, as well as The Best Game Ever, Bringing the Heat, Killing Pablo and Guests of the Ayatollah. He reported at The Philadelphia Inquirer for 20 years and now writes for Vanity Fair, The Atlantic and other magazines.
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New manuscripts posted at JBS Online
SLAS Share
"Cell-Permeable, Small-Molecule Activators of the Insulin-Degrading Enzyme" and "Development of a Profiling Strategy for Metabolic Mixtures by Combining Chromatography and Mass Spectrometry with Cell-Based GPCR Signaling" are among the new manuscripts available only to SLAS Biomolecular Sciences Section members ahead of print.
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Starfruit Software/Database Service - LTS per Study. You can control who to use a sample. Visit Store – Starfruit Library to see "Starfruit Sample Locator BIMS"
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Inline liquid handling system for sample and reagent processing in 96- and 384-well Array Tape™. Flexible inline modular options include dispensing, plate storage, incubation and dehydration.
Check it out!
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Quick, without checking the website first, which of these speakers is NOT keynoting SLAS2013, Jan. 12-16, Orlando?
- Mehmet Toner
- Justin Bieber
- Sir Harold Kroto
- Charles Sabine
Click here to give SLAS your answer.
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Scientists develop alternative to gene therapy
Science Daily Share
Scientists at The Scripps Research Institute have discovered a surprisingly simple and safe method to disrupt specific genes within cells. The scientists highlighted the medical potential of the new technique by demonstrating its use as a safer alternative to an experimental gene therapy against HIV infection. The new technique employs zinc finger nuclease proteins, which can bind and cut DNA at precisely defined locations in the genome.
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Stem cells used to create Huntington's model
Drug Discovery & Development Share
Scientists at the Gladstone Institutes and an international team of researchers have generated a human model of Huntington disease — directly from the skin cells of patients with the disease. For years, scientists have studied Huntington's disease primarily in post-mortem brain tissue or laboratory animals modified to mimic the disease.
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Combining crystallography and visible spectroscopy to understand enzymes
Phys.org Share
The research team focused on the stachydrine demethylase from Sinorhizobium meliloti 1021. The applications of electronic absorption and resonance Raman spectroscopies, in conjunction with x-ray diffraction, all derive from the same ~25 µm2 region of the crystal (intersection of the cross hairs). The x-ray beam alters the visible spectrum of the crystal with each exposure required to determine the crystal structure of the trimeric enzyme and the Fe-S cluster within each subunit.
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Sartorius Biohit presents the Picus, the smallest and lightest electronic pipette that eases your workload and provides accurate and precise results. This unique pipette design features patented electronic tip ejection and an intuitive user interface. The Picus has been presented with the 2012 “Red Dot” design award.
Discover Picus at www.sartorius.com/picus.
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Cisbio provides a panel of cellular kinase assays dedicated to the
measurement of site-specific phosphorylation, in an endogenous cellular
environment. These homogeneous assays represent a reliable, robust and
rapid alternative to classical technologies like Western Blot, ELISA or
bead-based assays.
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ALPAQUA® offers 24-well, 96-well & 384-well magnet plates with integrated spring technology for touch-off dispensing and complete supernatant removal while eliminating costly tip crashes and occlusions. Strong NdFeB magnets enable rapid, reliable bead capture and retention. Alpaqua magnet plates are SBS compliant and compatible with many liquid handlers, plate hotels & stackers.
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In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors
Journal of the American Chemical Society Share
There is a great demand for the discovery of new therapeutic molecules that combine the high specificity and affinity of biologic drugs with the bioavailability and lower cost of small molecules. Small, natural-product-like peptides hold great promise in bridging this gap; however, access to libraries of these compounds has been a limitation.
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Anticancer prospect made from scratch
Chemical & Engineering News Share
The natural product (+)-Fusarisetin A, which has promising anticancer properties and an unusually complex structure, has succumbed to total synthesis. (+)-Fusarisetin A has intrigued drug designers because experiments show that it inhibits migration and metastasis of cancer cells, seemingly without exhibiting cell-killing proclivities that might point to toxic tendencies.
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Study suggests somatic transposon insertion may help spur development of some cancers
Genome Web Share
Retrotransposon movement in somatic cells may introduce insertions in the genome that contribute to tumorigenesis in certain cancer types, according to a study in the early, online edition of Science by members of the Cancer Genome Atlas Research Network and their collaborators.
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Programmable RNA complex could speed genome editing in the lab
eBioNews Share
For bacteria, snipping apart DNA that bears certain signature sequences is a defense mechanism. For scientists working in the lab, the same strategy can be a powerful research tool. With a newly discovered component of an adaptive bacterial immune system, scientists have identified a targeted method of slicing DNA that they say can be easily customized for a variety of applications in the lab.
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TTP Labtech’s acumen eX3 can analyse over 40 images/second – allowing you to profile compound libraries in hours. Don’t sacrifice throughput for high content. MORE
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Fully Automated cells dispense, media exchange and cell based assay processing.
Click here for the MAP-C2 video of cell seeding and cell media exchange in Transwell® plates.
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Safety without sacrifice
Bioscience Technology Share
Whether identified as Repetitive Stress Disorder, Repetitive Stress Injury or Cumulative Trauma Disorders, musculoskeletal injuries in the workplace have been a serious issue for the past decade, amounting to tens of billions of dollars in costs associated with diagnosis and treatment. In a recent news release summarizing 2009 statistics, the U.S. Department of Labor, Bureau of Labor Statistics reported over 348,740 cases of ergonomically related injuries.
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Proteins: Disordered with a purpose
Live Science Share
Like guards who control entry and exit from a building, specialized molecules like the ion channel pictured with this article regulate which ions pass through a cell's membrane. Researchers have recently discovered that this channel has a special "messy" region that is important in its function.
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MyCell™ Services manufacture human induced pluripotent stem cells (iPSCs) and terminally differentiated cells from your donor samples, enabling specialized research studies. Choose the level of service your research requires:
•iPSC reprogramming
•Genetic engineering
•Cell differentiation
Cellular Dynamics International
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Structure-based design of novel inhibitors of the MDM2-p53 interaction
Journal of Medicinal Chemistry Share
Structure-based rational design led to the discovery of novel inhibitors of the MDM2–p53 protein–protein interaction. The affinity of these compounds for MDM2 was improved through conformational control of both the piperidinone ring and the appended N-alkyl substituent. Optimization afforded 29 (AM-8553), a potent and selective MDM2 inhibitor with excellent pharmacokinetic properties and in vivo efficacy.
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Giant living power cables let bacteria respire
New Scientist Share
It is the ultimate in subsea communications: bacteria living in sulphurous mud beneath the seabed respire by transforming themselves into long, insulating cables and shuttling electrons from one to another. This phenomenon has now been imaged for the first time, allowing us to see how some microbes pull off such a feat.
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App connects rare disease researchers to data
Genetic Engineering & Biotechnology News Share
Investigators of rare and neglected diseases can access some of the latest research in the field, plus data about the disorders themselves, through a recently launched free app for Apple devices. Sean Ekins, Ph.D., D.Sc., a consultant on computational drug discovery research, and Alex M. Clark, Ph.D., a designer of software for drug discovery scientists, have created Open Drug Discovery Teams.
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VIAFILL™ from INTEGRA delivers high performance bulk reagent dispensing, multichannel pipetting and microplate washing capabilities all from a single multipurpose instrument. A choice of different tubing sets allow quick changing between these three operational modes making VIAFILL a uniquely versatile lab tool.
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At Molecular Devices, we understand your desire for a top-of-the-line multi-mode microplate reader while balancing an ever-tightening budget. Get the reliability and sensitivity your lab deserves at the price-point you need from a name you trust. Learn more at info.moleculardevices.com
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Astech Projects launch new turnkey approach to automation at SLAS! Composed of four key steps – consultation & proposal, concept design study, proof of concept, and detailed design, manufacture and testing – Astech currently offers the initial consultation & proposal free of charge. Apply for yours today.
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