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Register Now for the 2017 SLAS Europe High-Content Screening Conference + SDDN 2017
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Make connections, learn valuable skills and collaborate Sept. 19-21 in Madrid, Spain, digging deep into HCS technology, data analysis, model systems and screens. Maximize your experience in Madrid by attending the Spanish Drug Discovery Network (SDDN) meeting on Sept. 21. The event schedule is posted along with preliminary speaker information. Significant discounts on registration fees are available until July 28. Scientific poster abstract submissions are being accepted until Aug. 21.

Read about last year's SLAS Europe High-Content Screening Conference in the SLAS Electronic Laboratory Neighborhood e-zine and SLAS Discovery.
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SLAS Discovery July Issue Online for Members and Subscribers
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Read about "A Combined In Vitro Assay for Evaluation of Neurotrophic Activity and Cytotoxicity," "Induced Pluripotent HD Monkey Stem Cells Derived Neural Cells for Drug Discovery," "Development of Novel Cell Lines for High-Throughput Screening to Detect Estrogen-Related Receptor Alpha Modulators," "Enabling 1536-Well High-Throughput Cell-Based Screening through the Application of Novel Centrifugal Plate Washing" and More.


SLAS Americas Council Looks Ahead
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The eight-member SLAS Americas Council met June 28 at SLAS Headquarters in St. Charles, Illinois, to review and discuss Americas region resources and services. Thanks to these members for giving of their time and talent to SLAS:

Chair Craig Schulz, Amgen
Vice Chair Andrea Weston, Pfizer
Secretary Sue Crimmin, GlaxoSmithKline
Neal Cosby, Promega
David Eddington, University of Illinois, Chicago
Hansjoerg Haas, Thermo Fisher Scientific
Aaron Wheeler, University of Toronto
Steve Young, Arcus Bioscience
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Cellular Technologies at SLAS2018
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Novel approaches for specific and efficient manipulation of human cells are driving the next revolution in biology, in much the same way that recombinant DNA technology fueled life sciences research for the past 40 years. Methodologies such as RNAi and CRISPR have enabled basic research to determine gene function and identify new drug targets within broad biological contexts at ever-increasing speed. Precision editing of genes coupled with continued innovation in the understanding and diversity of cell types promises the creation of more relevant models for phenotypic screening.

This SLAS2018 track focuses on emergent cellular technologies, including the development of gene editing tools, application of these tools to create accurate cellular models and functional screens used to make sense of the genetic complexity underlying disease and development. Track chairs are Benjamin Haley of Genentech and Neville Sanjana of New York University. For more information about this track and nine others, visit the SLAS2018 website. Podium abstract submissions are being accepted until Aug. 7.
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Advance Your Professional Success: Publish in SLAS Journals
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SLAS Discovery and SLAS Technology welcome manuscript submissions on an ongoing basis from SLAS members and non-members. Backed by the world-class education standards of SLAS, submissions are rigorously peer-reviewed and there are no article processing charges (APCs).

Open access options are available. SLAS journals address the full spectrum of issues that are mission-critical to life sciences professionals, enabling research teams to gain scientific insights; increase productivity; elevate data quality; reduce process cycle times; and enable research and development that otherwise would be impossible.
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Scientists Make Giant Molecular Cages for Energy Conversion and Drug Delivery
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Scientists from Trinity College Dublin and AMBER, the Science Foundation Ireland-funded materials science research centre hosted in Trinity College Dublin, have created "molecular cages" that can maximise the efficiency of converting molecules in chemical reactions, and that may in future also be used as sensors and drug-delivery agents. The cages can be packed with different molecules, many of which have a specific task or functionality. More


Sandia Labs Creates Better 'Fingerprints' to Detect Elusive, Valuable Chemical Compounds
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Imagine being able to see the entire Statue of Liberty and a small ant on its nose simultaneously. The drastic difference in size between the two objects would seem to render this task impossible. On a molecular level, this is exactly what a team led by Sandia National Laboratories chemists David Osborn and Carl Hayden accomplished with a special, custom-made instrument that has enhanced the power of a method called photoelectron photoion coincidence, or PEPICO, spectroscopy. More


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Cancer Studies Seem Replicable
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As part of the Reproducibility Project: Cancer Biology, independent teams of researchers attempt to replicate the experiments in a few dozen highly cited papers published from 2010 to 2012. They've already reported the results of replicating five papers, and recently, the results from re-doing the experiments of two more papers were posted in eLife, this time largely confirming the same conclusions as the original authors. More


Ancient Antiviral Defense System Could Revolutionize a New Class of RNA-based Medicine
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The billion-year-old primordial system by which early life forms protected themselves against viral infection can still be found in human cells, despite the presence of the much more sophisticated and powerful defense system that humans overwhelmingly depend on, say researchers at the Icahn School of Medicine at Mount Sinai. That ancient system, as simple as it is, might form the basis of the next era of precision medicine. More




CRISPR Platform Scans DNA to Predict Off-Target Effects
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
If you're reworking a genome, you might want to heed the old saying, "Measure twice, cut once." Otherwise, your attempts to right the genome or modify it for special purposes could end in genomic wrongs — off-target effects. For example, the popular gene-editing tool known as CRISPR could go astray, altering genes other than the ones it was meant to alter. If only CRISPR's potential slips could be foreseen! More


Chemists Discover Biology's Version of the Friedel-Crafts Alkylation
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By chemistry standards, the Friedel-Crafts alkylation is a venerable reaction. First reported by chemists Charles Friedel and James Crafts in 1877, the reaction attaches an alkyl substituent to an aromatic ring using an alkyl halide as one of the reactants. It turns out that nature has been doing this reaction for even longer — scientists just didn't know it until now. More


New System Makes Fast, Customized Antibiotic Treatments Possible
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A diagnostic system developed at the Technion-Israel Institute of Technology enables rapid and accurate customization of the antibiotic to the patient. The system makes for faster diagnostics, earlier and more effective treatment of infectious bacteria, and improved patient recovery times. The findings were published in the Proceedings of the National Academy of Sciences. More


Healing High-Loading Sulfur Electrodes with Unprecedented Long Cycling Life: Spatial Heterogeneity Control
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Self-healing capability helps biological systems to maintain their survivability and extend their lifespan. Similarly, self-healing is also beneficial to next-generation secondary batteries because high-capacity electrode materials, especially the cathodes such as oxygen or sulfur, suffer from shortened cycle lives resulting from irreversible and unstable phase transfer. More


Career


Field Support Scientist
Promega Corporation
United States

Scientific Manager/Group Leader, Biologics Sample Management – Early Research and Development
Genentech
US – CA – South San Francisco

Automation Research Associate (Robotics) (Mechanical Engineer)
DuPont Industrial Biosciences
US – CA – Palo Alto

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