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SLAS
Santosh Paidi, an innovative Ph.D. candidate from Johns Hopkins University (Baltimore, MD, USA), uses surface-enhanced Raman spectroscopy (SERS) to uncover the mysteries of circulating tumor DNA in the bloodstream, and encourages others to bravely tackle research problems outside their areas of expertise. "You can apply what you know already to answer questions in life sciences," says Paidi in a new article in the SLAS Electronic Laboratory Neighborhood (SLAS ELN). Paidi is recipient of the 2018 SLAS Graduate Education Fellowship Grant.
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SLAS
Travel to Brussels with SLAS CEO Vicki Loise's latest blog post as she captures the spirit of the inaugural SLAS Europe Conference and Exhibition. "This event was five years in the making," Loise reports. "Those attending the event felt it lived up to the SLAS standards of quality, with many options for networking, fascinating and entertaining keynotes and an excellent scientific program."
This is how the 2018 SLAS Europe Conference and Exhibition looked by the numbers:
- Attendees: just under 1,000
- Exhibitors: 94
- Countries Represented: 46
- Speakers: 70+
- Innovation AveNEW participants: 3
- Fun Run Registrants: 165 (only 30 runners)
- Workshops: 13
- Special Interest Group Meetings: 6
- SLAS Tony B. Academic Travel Award Winners: 10
- Scientific Poster Presenters: more than 120
- New Product Award Winners: 2
Plans for the 2019 SLAS Europe Conference and Exhibition in Barcelona, Spain, June 26-28 are well underway.
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SLAS
Fresh off the inaugural 2018 SLAS Europe Conference and Exhibition in Brussels, we are poised to keep the momentum going with fresh ideas for 2018-19 educational events in Europe. The SLAS Europe Scientific Program Committee seeks new members from academia, nonprofit, government and industry to contribute to year-long educational programming strategy, including the 2019 SLAS Europe Conference and Exhibition in Barcelona, Spain, as well as other in-person conferences and virtual events. Committee members should be SLAS Premier Members (dues-paying members) and are asked to commit to a three-year term of participation to ensure continuity and follow-through. View the full charter of the Europe Scientific Program Committee (Europe SPC). European volunteers are also sought to contribute their insight to the SLAS Advocacy Committee, Strategic Alliances Committee and Awards and Grants Committee. Interested members should complete the online volunteer form no later than July 31.
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Because drug discovery involves scientists from multiple disciplines and often organizations, it is critical to have an efficient mechanism for researchers to collaborate and realize the collective value of their specialized knowledge, assets, and capabilities. This free white paper details the essential keys to effective collaboration.
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SLAS
Learn more about stem cell and organoid potential at the 2018 SLAS Europe Advanced 3D Human Models and High-Content Analysis Conference, Oct. 17-19 (Leiden, The Netherlands). This innovative presentation, which examines opportunities that draw on the latest research into stem cell derived cardiac, neuronal, kidney, intestinal and various cancer organoid cultures, will be led by Sylvia Boj, Ph.D., of Hubrecht Organoid Technology (Utrecht, The Netherlands), and Christine Mummery, Ph.D., and Tom Rebelink, Ph.D., of the Leiden University Medical Center (Leiden, The Netherlands). Complete scientific program now online. Register before July 31: SLAS Premier Members save €80!
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BMG Labtech
Optimizing binding kinetics offers potential clinical benefits. A novel approach determines kinetic parameters such as on- and off-rates by continuous time-resolved FRET reads. This way, the PHERAstar FSX microplate reader simultaneously measures kinetics of hundreds of compounds. Prof. Steven Charlton (Nottingham University) explains how he studies kinetics of ligand-receptor binding.
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SLAS
The SLAS Discovery and SLAS Technology online archives feature carefully curated deep dives into topics of importance to life sciences researchers. From cancer metabolism and MALDI mass spec to 3D cell culture and collaborative 3D printing technologies, the breadth and depth of PubMed:MEDLINE-indexed SLAS special issues and collections showcase peer-reviewed science with practical value.
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SLAS
Master the exponential growth of data with tools to be presented in the Data Analysis and Informatics Track, one of 10 educational tracks to be offered at SLAS2019. Explore the rapidly evolving role of digital technology and scientific information management including the strategy and culture, as well as the hardware and software of the modern digital research lab. Look for ways to leverage technology to build the lab of the future, enable science through data sharing, integration, availability and associated tools, and learn how to digitalize lab workflows. Interested in contributing to the discussion? Podium abstracts for consideration to this track and others are due Monday, Aug. 6. Students: Apply for an SLAS Tony B. Academic Travel Award when you submit your podium or poster abstract. The travel award application and podium abstract deadline is Monday, Aug. 6. The deadline for travel awards for poster abstract submissions is Monday, Sept. 24.
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Journal of the American Chemical Society
In Alzheimer’s disease, amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the two pathological hallmarks. The co-occurrence and combined reciprocal pathological effects of Aβ and tau protein aggregation have been observed in animal models of the disease. However, the molecular mechanism of their interaction remain unknown. Using a variety of biophysical measurements, we here show that the native full-length tau protein solubilizes the Aβ40 peptide and prevents its fibrillation.
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Bioscience Technology
A critical link in mapping recurrent mutations of melanoma — the most serious form of skin cancer in humans — has been discovered by researchers at Washington State University School of Molecular Biosciences, in collaboration with researchers at Georgia State University.
In a paper published in Nature Communications, researchers established that DNA binding by a specific set of transcription factors, called ETS, is inherently mutagenic in UV-exposed cells.
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Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Genetic Engineering & Biotechnology News
Scientists from the European Molecular Biology Laboratory say they have adapted an existing technique to study the melting behavior of proteins so that it can be used for the study of bacteria. Antibiotic resistance is spreading worldwide so there is a strong need for new technologies to study bacteria, according to the researchers who published their study ("Thermal proteome profiling in bacteria: probing protein state in vivo") in Molecular Systems Biology.
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Phys.org
A team from the Chair of Inorganic Chemistry II at Ruhr-Universität Bochum has developed new chemical compounds that make catalysts more efficient. With their electronic and spatial properties, the new class of what are known as phosphine ligands ensures that catalysts are more active and more stable. In the journal Angewandte Chemie, researchers led by Prof Dr. Viktoria Däschlein-Gessner describe how the new ligands act on gold catalysts.
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Chemical & Engineering News
As effective as the palladium-catalyzed Suzuki reaction is for forming carbon-carbon bonds, researchers see room for improvement. Homogeneous palladium catalysts can be tough to separate from products, and fixing the problem by attaching catalysts to solid supports can lead to problematic metal leaching. Meanwhile, heterogeneous palladium nanoparticle catalysts on solid supports rarely catalyze the reaction efficiently.
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Lab Manager
New research published in The Lancet shows that an experimental HIV-1 vaccine regimen is well-tolerated and generated comparable and robust immune responses against HIV in healthy adults and rhesus monkeys. Moreover, the vaccine candidate protected against infection with an HIV-like virus in monkeys.
Based on the results from this phase 1/2a clinical trial that involved nearly 400 healthy adults, a phase 2b trial has been initiated in southern Africa to determine the safety and efficacy of the HIV-1 vaccine candidate in 2,600 women at risk for acquiring HIV.
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The Scientist
In a preprint posted to bioRxiv, researchers at the University of California, San Diego (UCSD) report using a CRISPR-Cas9 gene drive in mammals for the first time. Gene drives ensure that offspring preferentially inherit one parent's particular allele, so that a variant can quickly spread through a population even if it is detrimental to reproduction or survival. The UCSD researchers were only able to get a drive to work for female mouse offspring, and then only 73 percent of the time.
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Science Daily
A team led by the University of California San Diego has developed a chip that can detect a type of genetic mutation known as a single nucleotide polymorphism (SNP) and send the results in real time to a smartphone, computer, or other electronic device. The chip is at least 1,000 times more sensitive at detecting an SNP than current technology. The advance, published in Advanced Materials, could lead to cheaper, faster and portable biosensors for early detection of genetic markers for diseases such as cancer.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship, or post-doc opportunity. SLAS Premier Members get a discount on all new job postings.
Investigator (Tenure-Track) Position in Neuroscience
National Institute of Environmental Health Sciences/NIH
US – NC – Research Triangle Park
Senior/Principal Scientist, X-ray Crystallography
FORMA Therapeutics
US – MA – Watertown
Research Specialist I
Princeton University
US – NJ – Princeton
Search Jobs at SLAS Career Connections
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