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SLAS to Present Journal Author Workshops in the United Kingdom
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Join SLAS at ELRIG Drug Discovery 2017, Oct. 3-4, Liverpool, U.K. for step-by-step overviews of how to design and write scientific research papers more clearly and effectively to improve their chances for publication. Learn what editors want, what they don't want, common mistakes, insider tips and how reviewers evaluate manuscripts.

The sessions will be led by SLAS Discovery Editorial Board member and guest editor Rob Howes, Ph.D., of AstraZeneca (Switzerland). Registration is free.
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Keep Your Browser Pointed to slas2018.org!
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The SLAS2018 website is growing daily with new information about the Feb. 3-7 SLAS International Conference and Exhibition as scientific presentations and speakers are finalized, exhibitors confirm their booths and details on special events are published. NEW this week:

SLAS Journals Information Station: Meet members of the publishing team, including the SLAS Discovery and SLAS Technology editors-in-chief, and learn why you should read the SLAS journals to advance your research and publish in them to advance your professional success.

SLAS Exhibition Floor Plan: See where you'll find the most important providers of life sciences discovery and technology products and services during SLAS2018. Is someone missing? Encourage them to contact Barry Sacks and reserve one of the few remaining booths.
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Aaron Wheeler Named a 2017 'Pioneers of Miniaturization Lectureship' Winner
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Congratulations to Aaron Wheeler, SLAS Americas Council member, SLAS2013 co-chair and member of the SLAS Discovery Editorial Board, for being honored by Dolomite and Lab on a Chip with a distinguished 2017 Pioneers of Miniaturization Lectureship Award. He was selected for his contributions to digital microfluidics.

Wheeler is the author of more than 100 peer-reviewed publications, and has been the Canada Research Chair of Bioanalytical Chemistry at the University of Toronto since 2005. He receives a $2,000 cash prize and the opportunity to present a short lecture at the 2017 MicroTAS conference, Oct. 22-26, Savannah, GA.
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SLAS2018 Focus on Chemical Biology
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The SLAS2018 Chemical Biology Track lasers in on the challenges of addressing targets with small molecules including validation of targets using tool molecules and proof of target engagement through appropriate biomarker identification. Additionally, this track covers advances in library design, keeping libraries current and DNA-encoded libraries.

Planned sessions include "A Chemistry Focus on Small Molecule Libraries," "Affinity-Based Lead Discovery using DNA Encoded Chemistry" and "Target Selection and Validation." Track chairs are Jonathan O'Connell of Forma Therapeutics and Gwenn Hansen of Nurix. For more information about this track and nine others, visit the SLAS2018 website. Podium abstract submissions are being accepted until Aug. 7.
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Improbable Research: Get Creative With Blu-Tack
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Regular visits to the Improbable Research blog written by SLAS2018 keynote presenter Marc Abrahams will keep you laughing — and thinking — about science, research and life.

Last week, one post extolled the ingenious uses for Blu-Tack — that removable adhesive most often used by teenagers to hang posters in their bedrooms. Among the enlightening uses put forth in the blog: removing foreign (bodily) objects in the genitourinary system, gas flow regulation in stout can widget testing, making artificial lesions for x-ray imaging tests and making labyrinths for a hot ice computer. Imagine the possibilities! Abrahams delivers the SLAS2018 closing keynote on Wednesday, Feb. 7.
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Researchers Report Chemical Reaction With Potential to Speed Drug Development
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Chemists have long sought to develop new reactions for the direct conversion of simple hydrocarbon building blocks into valuable materials such as pharmaceuticals in a way that dependably creates the same chemical bonds and orientations. UT Southwestern researchers have hit upon a novel way to do that. The ability to consistently create desirable molecules and avoid undesirable ones could greatly accelerate pharmaceutical production. Many molecules come in two mirror-image configurations, often labeled left-handed and right-handed. More


Nanoparticles Coated With Antibiotic Eliminate Drug-Resistant Bacteria
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A new strategy to combat antibiotic-resistant bacteria has been described by Brazilian researchers in Scientific Reports, an online journal owned by Springer Nature. The method consists of coating nanoparticles that are made of silver and silica — potentially toxic to both microorganisms and human cells — with a layer of antibiotic. Owing to chemical affinity, the resulting nanopharmaceutical acts only on the pathogens and is inert to the organism. More


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Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The interplay between the intracellular gate and the selectivity filter underlies the structural basis for gating in potassium ion channels. Using a combination of protein semisynthesis, two-dimensional infrared (2D IR) spectroscopy, and molecular dynamics (MD) simulations, we probe the ion occupancy at the S1 binding site in the constricted state of the selectivity filter of the KcsA channel when the intracellular gate is open and closed. More


In Situ Microprobe Single-Cell Capillary Electrophoresis Mass Spectrometry: Metabolic Reorganization in Single Differentiating Cells in the Live Vertebrate (Xenopus laevis) Embryo
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Knowledge of single-cell metabolism would provide a powerful look into cell activity changes as cells differentiate to all the tissues of the vertebrate embryo. However, single-cell mass spectrometry technologies have not yet been made compatible with complex three-dimensional changes and rapidly decreasing cell sizes during early development of the embryo. Here, we bridge this technological gap by integrating capillary microsampling, microscale metabolite extraction, and capillary electrophoresis electrospray ionization mass spectrometry (CE-ESI-MS) to enable direct metabolic analysis of identified cells in the live frog embryo (Xenopus laevis). More




Key Advance in Neurofibromatosis Research Might Result in New Therapies
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Researchers from the University of Plymouth and Plymouth Hospitals NHS Trust say they have shed light on the role of the normal, cellular form of prion protein (PrPC) in the development of neurofibromatosis 2 (NF2)-related tumors. The hereditary condition, which mainly affects young people, is characterized by the development of multiple tumors of the nervous system, such as schwannomas, meningiomas and ependymomas, each associated with mutations in a gene coding for a tumor suppressor called Merlin. More


Kinky Biology: Researchers Explore DNA Folding, Cellular Packing With Supercomputer Simulations
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The nuclei of human cells are not even the most crowded biological place that we know of. Some bactiophages — viruses that infect and replicate within a bacterium — have even more concentrated DNA. "How does it get in there?" B. Montgomery (Monte) Pettitt, a biochemist and professor at the University of Texas Medical Branch, asks. "It's a charged polymer. How does it overcome the repulsion at its liquid crystalline density? How much order and disorder is allowed, and how does this play a role in nucleic acids?" More


Updated North American Trade Deal Could Boost US Chemical Exports
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With talks aimed at revising the North American Free Trade Agreement (NAFTA) expected to start soon, chemical manufacturers recently offered advice to the Trump Administration for updating the 23-year-old accord with Canada and Mexico. For chemical manufacturers, capitalizing on the shale gas revolution by securing expanded access to the two largest markets for U.S. chemical exports — Canada and Mexico — is a key goal, said Greg Skelton of the American Chemistry Council (ACC), an industry trade association. More


Scientists Get First Direct Look at How Electrons 'Dance' With Vibrating Atoms
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Scientists at the Department of Energy's SLAC National Accelerator Laboratory and Stanford University have made the first direct measurements, and by far the most precise ones, of how electrons move in sync with atomic vibrations rippling through an exotic material, as if they were dancing to the same beat. The vibrations are called phonons, and the electron-phonon coupling the researchers measured was 10 times stronger than theory had predicted. More


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