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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit July 19, 2017    SLAS2018    Moving? New job? Let SLAS know.      







SLAS Webinar: Detecting Small Molecule Non-Covalent Binders Utilizing SAMDI and the Bruker MALDI-TOF — Proof of Concept for a New Screening Format
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Erica C. VanderPorten, SLAS Discovery author and Genentech senior scientific researcher, presents her team's latest work to develop assays to support medicinal chemistry efforts, characterize and understand compound mechanism of action and investigate new lead finding technologies.

"Advances in technology afford the opportunity to revisit old challenges of detecting compound binding from mixtures," VanderPorten says. "We combined the ability of mass spectrometry to unambiguously identify and resolve compounds from complex mixtures of analytes with Self-Assembled Monolayers and matrix-assisted laser Desorption Ionization (SAMDI) technology." Register for the Oct. 17 live webinar (free to dues-paying members), and read her SLAS Discovery paper.


Data Analysis and Informatics at SLAS2018, Feb. 3-7, San Diego
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Modern life sciences research laboratories generate and analyze data from diverse sources. Informatics plays a critical role in the warehousing, analysis, visualization and flow of these data throughout organizations and between collaborators. This track focuses on the role of informatics in supporting new operational challenges, enabling knowledge and data discovery, facilitating secure collaboration and improving scientific productivity. Data Analysis and Informatics Track chairs are Margaret DiFilippo of Dotmatics and Amy Kallmerten of Merck.

Planned sessions include "Intelligent Decision Automation and Digitizing Lab Workflows," "Extracting Informed Decisions from Complex Data" and "Navigating Data from In Silico to In Vivo." For more information about this track and nine others, visit the SLAS2018 website. Podium abstract submissions are being accepted until Aug. 7.

Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)
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Read a new open access manuscript in SLAS Discovery from a University of Dundee team led by Ph.D. student Rachel E. Heap.

"Matrix-assisted laser desorption/ionization time-of-flight (MALDI TOF) mass spectrometry has become a promising alternative for high-throughput drug discovery as new instruments offer high speed, flexibility and sensitivity, and the ability to measure physiological substrates label free. Here we developed and applied high-throughput MALDI TOF mass spectrometry to identify inhibitors of the salt-inducible kinase (SIK) family, which are interesting drug targets in the field of inflammatory disease as they control production of the anti-inflammatory cytokine interleukin-10 (IL-10) in macrophages. Using peptide substrates in in vitro kinase assays, we can show that hit identification of the MALDI TOF kinase assay correlates with indirect ADP-Hunter kinase assays."

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SLAS Journals Invite Special Collection Proposals
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SLAS Discovery and SLAS Technology invite proposals from interested guest editors for collections of five to seven original scientific reports that collectively explore the different dimensions, recent achievements and existing challenges related to a timely topic of interest and importance to SLAS journal readers. Special collections published recently include: Learn about how you can contribute as guest editor and work closely with the journal editor-in-chief. More



A New Ligand Extends the Half-Life of Peptide Drugs from Minutes to Days
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Peptides are biological molecules, made up of short sequences of amino acids. Because they are easy to synthesize, show low toxicity and high efficiency, peptides such as insulin and other hormones can be used as drugs. But peptides are quickly cleared by the kidneys, which means that we can only use peptide drugs that act within minutes. More

Automating Reaction Discovery
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When hunting for novel chemical reactions, the more transformations chemists can do, the more likely they are to find something new. University of California, Berkeley, chemists John F. Hartwig and Konstantin Troshin have come up with an approach that lets reaction hunters run 75,000 possible reactions in just a matter of days using only a sealed 96-well plate, a gas chromatography/mass spectrometry instrument, and an analytical suite of Microsoft Excel macros. More

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In Situ Electron Microscopy of Plasmon-Mediated Nanocrystal Synthesis
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Chemical processes driven by nonthermal energy (e.g., visible light) are attractive for future approaches to energy conversion, synthesis, photocatalysis, and so forth. The growth of anisotropic metal nanostructures mediated by excitation of a localized surface plasmon resonance (LSPR) is a prototype example of such a reaction. Important aspects, notably the growth mechanism and a possible role of plasmonic "hot spots" within the metal nanostructures, remain poorly understood. More

Isotachophoresis-Based Surface Immunoassay
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In the absence of amplification methods for proteins, the immune-detection of low-abundance proteins using antibodies is fundamentally limited by binding kinetic rates. Here, we present a new class of surface-based immunoassays in which protein–antibody reaction is accelerated by isotachophoresis (ITP). We demonstrate the use of ITP to preconcentrate and deliver target proteins to a surface decorated with specific antibodies, where effective utilization of the focused sample is achieved by modulating the driving electric field (stop-and-diffuse ITP mode) or applying a counter flow that opposes the ITP motion (counterflow ITP mode). More

Malaria Genome Analysis Reveals an Abundance of Potential New Drug Targets
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The creation of the aerosol can, the transfer of the Panama Canal construction to the U.S., and the formation of the CDC are all a direct result of malaria's impact on human history, which cannot be overstated. Moreover, this single-cell parasite has been estimated to have caused the death of almost half of the world's population since the Stone Age and has directly influenced human evolution through natural selection from diseases such as sickle cell. More

Genome Therapy Could Lead to New Treatment for Life-Threatening Blood Disorders
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Genome therapy with beneficial natural mutation could lead to new treatment for life-threatening blood disorders By introducing a beneficial natural mutation into blood cells using the gene-editing technique CRISPR, a UNSW Sydney-led team of scientists has been able to switch on production of foetal haemoglobin — an advance that could eventually lead to a cure for sickle cell anaemia and other blood disorders. More

Scientists 'Resurrect' Ancient Proteins to Provide Clues About Molecular Innovation    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Enzyme activity is determined by the structure of a particular region of a protein called the active site. The generation of completely new active sites capable of enzyme catalysis is, arguably, one of the most fundamental unsolved problems in molecular biology. Rational and modern design approaches to this problem have been developed using complex computational methods, but without conclusive results. Indeed, protein engineering studies often suggest that the emergence of completely new enzyme active sites is highly improbable. More

New Device Detects Tumor Cells in Blood
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Researchers at the Universitat Rovira i Virgili's Department of Physical and Inorganic Chemistry, led by the ICREA researcher, Ramon Álvarez Puebla, and the professor of Applied Physics, Francesc Díaz, and the Department of Clinical Oncology of the HM Torrelodones University Hospital, have patented a portable device that can detect tumor cells in blood. The device counts the number of tumor cells in a blood sample in real time and is thus a highly effective tool for improving the monitoring, treatment and diagnosis of cancer. More


Clinical Trial Manager
Pacira Pharmaceuticals, Inc.
US – NJ – Parsippany

Automation Research Associate (Robotics) (Mechanical Engineer)
DuPont Industrial Biosciences
US – CA – Palo Alto

Field Support Scientist
Promega Corporation
United States

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