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July 22, 2020

SLAS NEWS

This Isn’t Your Standard Traffic Report In the latest episode of the New Matter: Inside the Minds of SLAS Scientists podcast, Mike interviews 2020 Ignite Award Winner Akwasi Apori, CEO & President of Correlia Biosystems, about a variety of topics including assay automation through microfluidics, the pride of watching a beta prototype sputter to life, and how to launch companies from academic labs and generate collaborative partners from unexpected places. LISTEN NOW

SLAS Discovery Releases Joint Issue with The Society of Biomolecular Imaging and Informatics SLAS The August special issue of SLAS Discovery, “High-Content Imaging and Informatics,” features a special collection of articles curated by guest editors Myles Fennell, Ph.D., and Paul A. Johnston, Ph.D., (The Society of Biomolecular Imaging and Informatics). The issue contains manuscripts, perspectives and one application note on a wide variety of research on the use of high-content screening (HCS) in the identification of androgenic activity associated with drugs, chemicals or environmental samples and its application to more physiologically relevant three-dimensional cell culture models in drug discovery. The issue also contains research on the use of image-based multiplexed cell painting HCS assays to extract morphological features from cells that can be organized into profiles corresponding to distinct cellular phenotypes. Lastly, the editors have included a summary of the discussion of the SLAS HCS/HCA Data and Informatics Special Interest Group (SIG) held at the SLAS2019 International Conference & Exhibition. DIG INTO AUGUST'S SLAS DISCOVERY

Just Published: August's Edition of SLAS Technology, 'Carbohydrate Structure Analysis: Methods and Application' SLAS August’s edition of SLAS Technology, “Carbohydrate Structure Analysis: Methods and Application,” is now accessible. In this edition, guest editors Christian Heiss, Ph.D., and Parastoo Azadi, Ph.D., (University of Georgia’s Complex Carbohydrate Research Center) selected nine articles highlighting new developments in three areas of carbohydrate analysis, including monosaccharide analysis, glycomics and glycan-protein interactions. The special collection also places an emphasis on the tremendous importance of carbohydrates in biology, medicine and biotechnology and how better methods for carbohydrate structure analysis are urgently needed. ACCESS SLAS TECHNOLOGY

SLAS Member Meet-Up — Clusters for All: CRISPR, Gene Editing, and Career Growth in Both SLAS Join SLAS for the first-ever virtual Member Meet-up, “Clusters for All: CRISPR, Gene Editing, and Career Growth in Both,” hosted by Samuel Hasson (Voyager) and John Doench (Broad Institute) and moderated by SLAS Board Member Sammy Datwani. The Member Meet-Up will take please Wednesday, July 29 from 12:00 – 1:00 p.m. CDT and spots are VERY limited to allow for Q&A. RESERVE YOUR SPOT

SPONSORED VIDEO The Ultimate Laboratory Microplate Mover The Thermo Scientific™ Orbitor™ RS2 microplate mover is a collaborative bench-top mover that provides unbeatable reliability and improved process efficiency. It’s innovative bi-directional telescoping arm coupled with it’s expansive 360° workspace provide exceptional reach and precision, making the Orbitor RS2 your trusted laboratory productivity partner. WATCH VIDEO

Discover the Magic of SLAS SLAS In this month’s From the President, Emilio Diez Monedero reflects on the “magic power” of participating in the SLAS International Conference and Exhibition and its lasting effects on those who have presented a paper, met their new research collaborator or business partner and the start-ups who have gained significant jump-starts by participating on Innovation AveNEW. Read more about the advantages of conference — and Innovation AveNEW — participation in Electronic Laboratory Neighborhood. READ JULY'S MESSAGE FROM THE SLAS PRESIDENT

Now Available: Two SLAS Discovery COVID-19-Related Research Articles SLAS Keep up with the latest SARS-CoV-2 research with two recently published articles in the June and July editions of SLAS Discovery. Each article features research from the University of Calabria (Italy) and the National Center for Advancing Translational Sciences, National Institutes of Health (Maryland, USA), respectively. Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19 RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery

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Save the Date: What Role can Laboratory Automation Play Post Lockdown? SLAS On Wednesday, July 29 from 3:00 – 4:00 p.m. GMT+1, join Hansjoerg Haas, Ph.D., and Ian Yates, Ph.D., (Thermo Fisher) for the One Nucleus BioWednesday webinar, “What Role can Laboratory Automation Play Post Lockdown?” They, along with other laboratory automation professionals, will discuss how labs are restructuring their workspaces to accommodate social distancing measures and how lab environments and research needs will change in a post-pandemic world. RESERVE YOUR SPOT

Calendar of Important Dates SLAS Additional SLAS Journals Call for Papers Emerging Trends in 3D Cell Culture: High-Throughput Screening, Disease Modeling & Translational Medicine SLAS Technology Submission Deadline Extended to August 1 Applications of Biophysics in Early Drug Discovery SLAS Discovery Submission deadline: September 1 Fuzzy Systems in Bioinformatics and Computational Biology SLAS Technology Submission deadline: September 1 SLAS Events Outlook SLAS is committed to providing a safe meeting space, high-quality education and meaningful networking opportunities for all attendees, whether in person or on a virtual platform, as circumstances warrant. We look forward to convening in person but will do so only if and when we can provide a safe and appropriate meeting venue as well as suitable accommodations for travelers. The SLAS team is monitoring all aspects of event logistics and solidifying plans to enable alternative forms of knowledge sharing. Clusters for All: CRISPR, Gene Editing, and Career Growth in Both SLAS Member Meet-Up Wednesday, July 29v12:00 – 1:00 p.m. CDT What Role can Laboratory Automation Play Post Lockdown? One Nucleus Webinar Wednesday, July 29 3:00 – 4:00 p.m. GMT+1 Compound-Mediated Interferences in Homogenous Proximity Assays Webinar Thursday, August 27 12:00 p.m. CDT READ MORE

SPONSORED CONTENT Promoted by Corning • Is your lab reopening? Check out these tips to keep you safe during a pandemic. • Ramping up drug, vaccine and infectivity testing with airway organoids. • 3D cell culture could drive the fight against infectious diseases • Why HUB organoids are key to advancing personalized cancer therapies • Organoid vs. spheroid: What’s the difference?

HEADLINES

The Self-Assembly of a Cyclometalated Palladium Photosensitizer into Protein-Stabilized Nanorods Triggers Drug Uptake In Vitro and In Vivo Journal of the American Chemical Society Enhanced passive diffusion is usually considered to be the primary cause of the enhanced cellular uptake of cyclometalated drugs because cyclometalation lowers the charge of a metal complex and increases its lipophilicity. However, in this work, monocationic cyclometalated palladium complexes OAc (N^N^C^N) and OAc (N^N^N^C) were found to self-assemble, in aqueous solutions, into soluble supramolecular nanorods, while their tetrapyridyl bicationic analogue (OAc)2 (N^N^N^N) dissolved as isolated molecules. READ MORE

Heme Determination and Quantification Methods and Their Suitability for Practical Applications and Everyday Use Analytical Chemistry Many research institutions, clinical diagnostic laboratories, and blood banks are desperately searching for a possibility to identify and quantify heme in different physiological and pathological settings as well as various research applications. The reasons for this are the toxicity of the heme and the fact that it acts as a hemolytic and pro-inflammatory molecule. Heme only exerts these severe and undesired effects when it is not incorporated in hemoproteins. READ MORE

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Recently Discovered CRISPR Enzyme Expands Genome Editing Toolbox Lab Manager A recently discovered hypercompact CRISPR enzyme found only in huge bacteriophages, and known as CRISPR-CasΦ, is functional, a new study by Patrick Pausch, Jennifer Doudna and colleagues reports. The enzyme also provides a powerful new tool in the CRISPR genome editing toolbox, because it can target a wider range of genetic sequences compared to Cas9 and Cas12. READ MORE

Huntington's Disease Tied to Mitochondrial RNA Release, Innate Immune Activation Genetic Engineering & Biotechnology News Huntington’s disease is a progressive brain disorder caused by mutations in the HTT gene, which encodes the protein huntingtin. The HTT mutation is a CAG trinucleotide repeat that, when repeated more than 36 times, can lead to the disorder that is characterized by uncontrolled movements and loss of cognition. The mechanisms by which mutant huntingtin leads to neuronal cell death in HD are not fully understood. READ MORE

PRODUCT SHOWCASE

Convenient. Consistent. Certain. Matrigel matrix-3D plates are a pre-coated, convenient, off the shelf option that improve productivity and consistency in homogenous assays where 3D structures are grown and assayed directly in the plate. Using a pre-coated option eliminates the need to handle small volume ECM dispensation and helps reduce workflow steps LEARN MORE High quality biospecimens available from surgeries, autopsies and other routine procedures The CHTN is a unique NCI supported resource that provides human tissues and fluids from routine procedures to investigators who utilize human biospecimens in their research. Unlike tissue banks, the CHTN works prospectively with each investigator to tailor specimen acquisition and processing to meet their specific project requirements. LEARN MORE

A New Directed Evolution Technique to Unlock the Potential of Xeno-Nucleic Acids Phys.org As well as being required for some of the core techniques of molecular biology, reverse transcriptase enzymes have played a key role in synthetic genetics by enabling synthesis, replication, and evolution of xeno-nucleic acids. However, for most XNA chemistries, no RT enzymes are available or existing enzymes have low activity. Philipp Holliger's group, in the LMB's PNAC Division, have developed a new directed evolution method to improve RT activity for any nucleic acid chemistry and discovered a new group of optimal RT enzymes. READ MORE

Melamine Mediates Formation of Polythymine Duplexes Chemical & Engineering News Interactions between DNA and small molecules can provide new options for the assembly of DNA nanostructures. Hanadi F. Sleiman of McGill University, Hanbin Mao of Kent State University, Chengde Mao of Purdue University, and coworkers show that melamine triggers the formation of polythymine duplexes. On two of its three faces, melamine forms three hydrogen bonds with thymine. READ MORE

Seeking an Early COVID-19 Drug, Researchers Look to Interferons The Scientist Early this year, when COVID-19 was still a localized outbreak in China, Eleanor Fish, an immunologist at the University of Toronto, reached out to colleagues in Wuhan to explore the possibility of evaluating interferon therapy in patients infected with the coronavirus. Fish has been studying interferons — proteins produced by the body in response to viral infections — for close to 35 years, and her previous favorable results with a synthetic version during the 2003 SARS outbreak in Canada prompted the idea. READ MORE

Gel That Breaks Down, Puts Itself Back Together Could Improve Delivery of Oral Drugs Science Daily An emerging hydrogel material with the capacity to degrade and spontaneously reform in the gastrointestinal tract could help researchers develop more effective methods for oral drug delivery. "The majority of drugs and nutrients are absorbed into the body in the intestines, but to get there, they have to traverse the stomach — a very acidic, harsh environment that can interfere with the active molecules in pharmaceuticals," says Kelly Schultz, an associate professor of chemical and biomolecular engineering at Lehigh University. READ MORE

CAREER CONNECTIONS

Job Seekers: Post your résumé and sign up for new job alerts by keyword. Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings. Scientist, Compound Logistics and Automation, Lead Discovery F. Hoffmann-La Roche AG EU – Switzerland - Basel Postdoctoral Research Associate in Microbiology University of Nebraska Medical Center US – NE – Omaha Research Lab Technician I USC US – CA – Los Angeles Search Jobs at SLAS Career Connections

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