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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit July 23, 2014

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SLAS2015 Podium Abstract Submissions Due July 28
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Join your peers at the intersection of science and technology by presenting your research achievements at SLAS2015. Due date for consideration is Monday, July 28. Tracks include:
  • Assay Development and Screening
  • Automation and High-Throughput Technologies
  • Bioanalytical Techniques
  • Biomarker Development and Applications
  • Drug Target Strategies
  • Informatics
  • Micro/Nano Technologies
Be sure to note your interest in the Tony B. Academic Travel Award and/or the SLAS Innovation Award programs if appropriate.
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SLAS ELN Reports: Drug Repurposing - Helping Companies Expand Treatment Options for Patients and Recoup Investments
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Compared with trying to discover and develop a novel compound from scratch, repurposing an approved drug saves time and money.

Repurposing also carries less risk to companies and to patients, according to SLAS Drug Repurposing SIG co-chairs Roger Bosse and Mathieu Arcand in the new article in the SLAS Electronic Laboratory Neighborhood e-zine.
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New Technology Brief at JALA Online
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A team from Sandia National Laboratory describes their automated microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins and posttranslational modifications in single intact cells with >95% reduction in reagent requirement in under 8 h.

The full brief is available now to SLAS Laboratory Automation Section members and JALA subscribers.
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New Lab-on-a-Chip Short Course at SLAS2015
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"Lab-on-a-Chip: From Technology to Bioanalysis on Chip" will be held Saturday, Feb. 7. This SLAS2015 Short Course, one of seven new or re-engineered courses, is intended to be a "how to" primer for those interested in how miniaturization and microfluidics enable novel applications in analytical chemistry, pharmaceuticals, biomedicine and more.

Faculty members Sabeth Verpoorte of the University of Groningen, Johan Nilsson from Lund University and Jörg P. Kutter of the Technical University of Denmark will share their combined 60-plus years of experience with course participants.
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Planned Maintenance for SLAS Members' Only Pages
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SLAS is upgrading its organizational database to deliver a better user experience to members. As part of this upgrade, the Members' Only pages at SLAS.org will be unavailable from Monday, July 28 until Thursday, July 31 U.S. time.

These pages include the membership directory, webinar registration and member profile pages. During this period, the public pages of SLAS.org, as well as SLAS2015.org, eln.slas.org, JALA Online and JBS Online, will remain accessible and fully functional.
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Attention JALA and JBS SAGEtrack Users
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If you are registered as a user in the JALA SAGEtrack or JBS SAGEtrack manuscript submission systems, please take a moment to login and review your user profile to ensure it is accurate and up-to-date. Please pay special attention to your contact information and your personal attributes/keywords. Thank you. More


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    Researchers Create Safe, Resistant Material to Store Waste
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Storing industrial waste has never been a pretty job, and it's getting harder. New techniques for refining such metals as aluminum and vanadium, for example, also yield new byproducts that have to be sealed away from human and environmental contact. And the practice of "scrubbing" the exhaust of coal-fired power plants keeps chemicals like sulfur dioxide from entering the air, but produces a more concentrated residue. More

    Gene Described as Critical to Stem Cell Development
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Scientists at Michigan State University say they have found that a gene known as ASF1A could be critical to the development of stem cells. ASF1A is at least one of the genes responsible for the mechanism of cellular reprogramming, a phenomenon that can turn one cell type into another, which is key to the making of stem cells, according to the researchers. More

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    Tips for Establishing Successful Cell-Based Assays: Part 1
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    Cell-based assays are a critical part of the workflow for discovering new chemical entities. They are used throughout the drug discovery process from target validation, primary and secondary compound screening to determining the safety and selectivity of new leads. Since they are ubiquitously used, it is with utmost importance that one chooses appropriate cells, assay conditions and designs, and data analysis. The following sections on cell-based applications provide general guidance in designing robust cell- based assays for screening and lead optimization. More
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    Using EMR Databases to Conduct Clinical Research
    By Maria Frisch    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Electronic medical records contain enormous amounts of information that could be used in clinical research and quality improvement. However, ethical concerns — such as patient consent and minimization of reidentification — abound. For those accessing records tied to clinics, hospitals, insurance companies and similar organizations, multiple databases are typically accessed to pull records. Utilization of this data often involves approval from an institutional review board and documentation of HIPAA compliance. More

    How We'd Really Deal With the Pandemic in 'The Last Ship'
    Discover     Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A United States Navy Destroyer is sent to the Arctic and ordered to radio silence for four months. During that time, a mysterious virus — 100 percent fatal and 100 percent contagious — spreads from isolated pockets in Africa and Asia into a pandemic. When radio silence ends and the captain and his 217 crew finally learn what's going on, 80 percent of the human population is either dead or dying, and all government control has collapsed. More

    Risks of Flu Research Demand Openness From Labs
    Live Science    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The danger of reporting findings before peer review is that scientists often can't talk about the details of their research, which can lead to hype or fear in the media. A recent example of this is a controversial influenza study led by Yoshihiro Kawaoka at the University of Wisconsin-Madison, first reported by the Independent. More


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    Rapid Kinetic Characterization of Glycosyl Hydrolases Based on Oxime Derivatization and Nanostructure-Initiator Mass Spectrometry
    ACS Chemical Biology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Glycoside hydrolases are critical to cycling of plant biomass in the environment, digestion of complex polysaccharides by the human gut microbiome, and industrial activities such as deployment of cellulosic biofuels. High-throughput sequencing methods show tremendous sequence diversity among GHs, yet relatively few examples from the over 150,000 unique domain arrangements containing GHs have been functionally characterized. More

    Drug Combo 'Game Changer' for Drug-Resistant TB
    New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The first new medication in half a century for the widespread treatment of tuberculosis has also shown the potential to cure drug-resistant TB. While only preliminary, the trial results of a triple-drug combination called PaMZ, unveiled at the annual International AIDS Conference, in Melbourne, Australia, on Saturday, offer the best hope in decades of bringing under control a pernicious, drug-resistant form of the disease. More

    Scientists Identify Gene that Plays a Surprising Role in Combating Aging
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    It is something of an eternal question: Can we slow or even reverse the aging process? Even though genetic manipulations can, in fact, alter some cellular dynamics, little is known about the mechanisms of the aging process in living organisms. Now scientists from the Florida campus of The Scripps Research Institute have found in animal models that a single gene plays a surprising role in aging that can be detected early on in development. More



    Detection of Thermoresponsive Polymer Phase Transition in Dilute Low-Volume Format by Microscale Thermophoretic Depletion
    Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Environmentally responsive polymers are becoming increasingly important in the biomaterials field for use as diagnostic reagents, drug carriers, and tissue engineering scaffolds. Characterizing polymer phase transitions by cloud point curves typically requires large milliliter volumes of sample at high micromolar solution concentrations. More

    Chemists Eye Improved Thin Films With Metal Substitution
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The yield so far is small, but chemists have developed a low-energy, solution-based mineral substitution process to make a precursor to transparent thin films that could find use in electronics and alternative energy devices. A paper describing the approach is highlighted on the cover of the July 21 issue of the journal Inorganic Chemistry, which draws the most citations of research in the inorganic and nuclear chemistry fields. More

    How Does Acetaminophen Work? Researchers Still Aren't Sure
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Open a medicine cabinet in the U.S., and it's likely that acetaminophen, a pain reliever and fever reducer, will be inside. It might be in a pill or a gelcap. It might come in the form of an over-the-counter cold remedy or a prescription medicine such as Vicodin. Acetaminophen is everywhere. So it may come as a surprise to learn that experts aren't quite sure how the drug works. More


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