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Micro- and Nanotechnologies for Quantitative Biology and Medicine
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The August issue of SLAS Technology showcases 10 new reviews and original research reports that illustrate how the progression of research assays from qualitative outputs toward increasingly sensitive quantitative outputs is transforming life sciences and biomedical research and diagnostics by improving the ability of researchers and clinicians to detect and quantify increasingly complex assays.
The issue includes an in-depth two-part review on digital assay partitioning statistics, digital PCR, digital protein and cell assays by Amar Basu, Ph.D., of Wayne State University. "This review is intended to give a broad perspective to scientists interested in adopting digital assays into their workflows," says Basu. Visit SLAS Technology Online to read the special issue (for select SLAS Premier members, Premier Plus members, SLAS Technology subscribers and pay-per-view readers). All can listen to a free podcast with Dr. Basu.
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What Would Your SLAS2018 'Where Discovery Meets Technology' Online Handle Be?
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The Internet is replete with online handles like "lethal_bacon" or "journey_dieselpunk27." If you had to create an online handle inspired by the SLAS2018 "Where Discovery Meets Technology" theme, what would yours be?
Well ... you don't have to think too hard — just use the handy SLAS name generator to determine your personal discovery-technology moniker!
Then be sure to submit an abstract by Aug. 7 to present at SLAS2018, Feb. 3-7, San Diego, and share your new handle on social media.
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SLAS Nominations Committee Now Accepting Applications for SLAS Board of Directors
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The SLAS Nominations Committee will soon select three individuals to join the SLAS Board of Directors for three-year terms of service beginning in 2018. Candidate applications for the SLAS Board of Directors are being accepted from the membership community through Aug. 25, 2017.
All candidates must have the capacity and commitment to serve, and meet the required criteria outlined in the SLAS Strategic Plan, SLAS Board of Directors Selection Policy and the SLAS Bylaws. The new board members will replace those completing their terms: Scott Atkin, Michele Cleary and Susan Lunte.
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Control of the Unfolded Protein Response in Health and Disease
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Information generated by screening tools, readily available therapies and potential pathways to drug development are the cornerstone of informed clinical research and clinical trial design. In a new review in the August 2017 issue of SLAS Discovery, authors Eric Chevet, Ph.D., of Inserm U1242 (Rennes, France) et al. analyze the recent literature and review the impact of unfolded protein response in health and disease.
In addition, 11 original research reports including "Robotic Mammosphere Assay for High-Throughput Screening in Triple-Negative Breast Cancer," "Discovery of Novel Gq-Biased LPA1 Negative Allosteric Modulators," "A Systematic Approach to Identify Biased Agonists of the Apelin Receptor through High-Throughput Screening" and "Drug Library Screening for the Identification of Ionophores That Correct the Mistrafficking Disorder Associated with Oxalosis Kidney Disease" and two technical notes are featured in the issue now available to select SLAS Premier members, Premier Plus members, SLAS Discovery subscribers and pay-per-view readers at SLAS Discovery Online.
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SLAS ELN Reports: New Products Taking Center Stage in Life Sciences Discovery and Technology
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Innovators and entrepreneurs behind the top technologies featured at SLAS2017 were armed with diverse discoveries that ranged from an advance in nucleic acid extraction, to an automated benchtop micropipettor, to a fully automated single cell transfection technology for adherent cells.
The companies behind these new ideas in life sciences discovery and technology share what's next in the SLAS Electronic Laboratory Neighborhood e-zine. Learn about how earning a 2017 SLAS New Product Award jump-started infinitesimal (Skokie, IL), Avidien Technologies (Hudson, MA) and Analytik Jena US (Beverly, MA).
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Drug Target Strategies at SLAS2018, Feb. 3-7, San Diego
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Drug discovery relies on a deep understanding of the biology underlying disease states and the mechanisms-of-action of active drug leads. This track focuses on emerging strategies for selecting drug discovery approaches and evaluating drug leads, and includes sessions such as "Multi-Modal Approaches to Mechanism of Action Determination," "Integrating Novel Target Engagement Strategies into Drug Discovery" and "Platform Strategies to Exploit Atypical Modes of Action."
Drug Target Strategies Track chairs are Chun-wa Chung of GlaxoSmithKline and Peter Hodder of Amgen. For more information about this track and nine others, visit the SLAS2018 website. Podium abstract submissions are being accepted until Aug. 7.
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Scientists Enlist Baker's Yeast in a Hunt for New Medicines
Phys.org Share
One of the hardest parts in drug discovery is pinning down how a medicine actually works in the body. It took nearly 100 years to uncover the molecular target of aspirin, but even with cutting-edge technology, it can take years to untangle how drugs interfere with cells. And yet, to develop medicines that target disease effectively and are safe — with no side effects — these molecular insights are key.
Now a new method developed by an international research team has the potential to accelerate target discovery with help from yeast cells, which are a simpler version of human cells but far better known at the molecular level.
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Scientists Develop New Supplement That Can Repair, Rejuvenate Muscles in Older Adults
Lab Manager Share
Whey protein supplements aren't just for gym buffs according to new research from McMaster University. When taken on a regular basis, a combination of these and other ingredients in a ready-to-drink formula have been found to greatly improve the physical strength of a growing cohort: senior citizens.
The deterioration of muscle mass and strength that is a normal part of aging — known as sarcopenia — can increase the risk for falls, metabolic disorders and the need for assisted living, say researchers.
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Silencing Mitochondrial Genes With a Designer Molecule
Chemical & Engineering News Share
Mitochondria, the organelles which collectively serve as a cell's powerhouse, are like miniature fortresses. Getting synthetic chemicals past this organelle's formidable double membrane isn't easy. As a result, scientists haven't yet been able to develop any drug treatments that address the core problems underlying mitochondrial disorders, which can be deadly. Now, researchers have developed a peptide-like molecule that penetrates this membrane and targets the mitochondrial genome.
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Mammalian Immunity: What's RNAi Got to Do with It?
The Scientist Share
Had Xi Zhou known what he was in for a few years ago, he might never have gone looking for RNA interference (RNAi) in mammals. "At that time we are very young and kind of naive," he says of himself and his collaborators.
But Zhou, a biologist at the Wuhan Institute of Virology in China, was intrigued by two 2013 papers that presented evidence of an RNAi response against viruses in mouse embryonic stem cells, baby hamster kidney cells and newborn mice.
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Can a Laboratory be Safe and Efficient While Still Cutting Costs?
Bioscience Technology Share
In today's laboratories, there's an extensive range of safety rules, guidelines and criteria that must be followed. These rules cover everything from the people working in laboratories and making products, to understanding how the creation of a product impacts the environment.
So that individuals and companies can show compliance, any information relating to these safety rules and procedures needs to be documented and reported on. But, with organizations increasingly trying to do more whilst cutting costs, do they risk cutting corners on safety?
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Antibody Factory in a Dish
Genetic Engineering & Biotechnology News Share
A novel in vitro vaccine booster strategy could lead to faster production of human monoclonal antibodies (mAbs) and shorten vaccine development by speeding evaluation of antigens, according to researchers. In a paper published in the Journal of Experimental Medicine, an international group of researchers led by Facundo Batista, PhD, associate director of the Ragon Institute of Massachusetts General Hospital, Harvard, and MIT, described a method to stimulate human memory B cells to produce antigen-specific antibodies.
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3-D Imaging of Surface Chemistry in Confinement
Science Daily Share
EPFL researchers have developed an optical imaging tool to visualize surface chemistry in real time. They imaged the interfacial chemistry in the microscopically confined geometry of a simple glass micro-capillary. The glass is covered with hydroxyl (-OH) groups that can lose a proton — a much-studied chemical reaction that is important in geology, chemistry and technology. A 100-micron long capillary displayed a remarkable spread in surface OH bond dissociation constant of a factor of a billion.
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Salen-Based Covalent Organic Framework
Journal of the American Chemical Society Share
The Salen unit represents one of the most important ligands in coordination chemistry. We report herein the first example of a Salen-based covalent organic framework (COF), in which both the construction of the COF structure and the functionalization with Salen moieties have been realized in a single step. Due to its structural uniqueness, the obtained COF material, Salen-COF, possesses high crystallinity and excellent stability. Based on this, a series of metallo-Salen-based COFs were prepared via metalation for further applications.
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Four Post-Doctoral Positions in Systems and Computational Neuroscience
University of Pittsburgh
US – PA – Pittsburgh
Application Research Chemist
Michelman
US – OH – Cincinnati
Automation Research Associate (Robotics) (Mechanical Engineer)
DuPont Industrial Biosciences
US – CA – Palo Alto
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SLAS Point-to-Point
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