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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit July 27, 2016

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SLAS ELN Reports: Beyond the Hype and the Headlines — Open Source Platforms Put the Power of 3D Printing into Life Sciences
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In the past, laboratories used a glass blower and an in-house machine shop to churn out customized parts needed for experiments. Then, 3D printers arrived with an on-demand supply of wares made of everything from plastics and metals to wax and living tissue. Now, open source platforms put the real power of 3D printing into the hands of life sciences discovery and technology professionals.

If your lab is not already using a 3D printer, it's feasible to start today, say James Gill, Ph.D., and Alden Hart, B.Sc., E.E., guest editors of a special collection on 3D printing appearing in the August 2016 issue of Journal of Laboratory Automation (JALA). For additional insight, read the newest feature article in the SLAS Electronic Laboratory Neighborhood e-zine, and listen to Gill and Hart in the new JALA podcast.
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Aug. 8 Deadline Nears for SLAS2017 Scientific Podium Abstracts
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Monday, Aug. 8, is an important day for those who wish to present in the SLAS2017 podium program and/or secure a Tony B. Academic Travel Award spot on the podium. Be sure to click through the links above and tell SLAS — and, eventually, your peers — how you are leveraging the power of new technologies to achieve scientific objectives.

Other upcoming deadlines:
Sept. 26: Tony B. Academic Travel Award poster applications
Oct. 31: Student Poster Competition abstracts
Jan 5: Hotel reservations at discounted rate
Jan. 23: Final due date for poster abstracts

Important SLAS2017.org links:
Exhibition map and participating companies
Scientific track and session information
Short Course program
Which Reagent Are You? quiz

SLAS2017 registration will open in early fall.
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Novel Biomarkers for Renal Diseases? None for the Moment (but One)
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In the August 2016 issue of the Journal of Biomolecular Screening (JBS), authors Giorgio Gentile and Giuseppe Remuzzi present a comprehensive review of novel biomarkers for renal disease in a number of different clinical conditions.

Plus, original research reports address "Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen," "FRET-Protease-Coupled Peptidyl-Prolyl cis-trans Isomerase Assay: New Internally Quenched Fluorogenic Substrates for High-Throughput Screening" and "A New Surface Plasmon Resonance Assay for In Vitro Screening of Mannose-Binding Lectin Inhibitors," and more.
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SLAS Webinars: Immediate Access, Lasting Value
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SLAS Webinars deliver valuable insight to life sciences professionals 24/7 from the convenience of your web browser. Here are some high profile offerings from the SLAS Webinar library, immediately accessible at your convenience:

Current Applications for Mass Spectrometry within Drug Discovery (Jonathan Wingfield, AstraZeneca)
The Value of Phenotypic-Based Drug Discovery (David C. Swinney, Institute for Rare and Neglected Diseases Drug Discovery)
Rules and Filters and Their Impact on Success in Chemical Biology and Drug Discovery (Chris Lipinski, Melior Discovery)

Not yet an SLAS member? Join now!
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New and Free in JALA August: Miniaturization Technologies for Efficient Single-Cell Library Preparation for Next-Generation Sequencing
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As the cost of next-generation sequencing has decreased, library preparation costs have become a more significant proportion of the total cost, especially for high-throughput applications such as single-cell RNA profiling.

In this JALA manuscript, a collaborative team from the University of California, San Diego (U.S.) and TTP Labtech (U.K.) apply novel technologies to scale down reaction volumes for library preparation. Their system consists of in vitro differentiated human embryonic stem cells representing two stages of pancreatic differentiation and multiple biological and technical replicates.
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A Tiny Answer to the Counterfeit Drug Problem
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The counterfeit drug industry is thriving. Criminals are cashing in on an estimated $200 billion in profits — nearly 10 percent of pharmaceuticals worldwide — while unknowing consumers put their health or even lives at risk. Jun Wang has seen the numbers and he's turning to microtechnology for a solution. Wang, an assistant chemistry professor, is leading a team of University at Albany researchers in developing microsize QR codes that can be used to authenticate medicine, as well as any other product that has potential for counterfeit. More


CRISPR Therapy to Enter Trials
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Oncologist You Lu of Sichuan University's West China Hospital in Chengdu and colleagues will soon begin trialing a new CRISPR-based immunotherapy in 10 patients with non-small cell lung cancer that has metastasized and is not responding to treatment. The hospital's review board approved the study, and the team hopes to treat the first patient next month, according to Nature. More


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Volatile Single-Source Precursors for the Low-Temperature Preparation of Sodium—Rare Earth Metal Fluorides
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Heterometallic single-source precursors for the preparation of sodium–rare earth metal fluorides are reported. Fluorinated β-diketonates NaRE(hfac)4 (RE = Y (1), Er (2), and Eu (3); hfac = hexafluoroacetylacetonate) have been obtained on a large scale, in high yield, via one-pot reaction that utilizes commercially available starting reagents. The solid-state structures of the title complexes consist of 1D polymeric chains with alternating [Na] and [RE(hfac)4] units. More


Highly Sensitive Devices for the Detection of Biological and Chemical Compounds
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Surface plasmon resonance (SPR) devices are the benchmark in optical sensing. They are used for detecting biomarkers of disease, discovering drugs, analyzing chemicals, ensuring food quality and safety, and detecting pollutants in our environment. SPR devices can detect molecules within a few hundred nanometres of their metal surfaces. When a target molecule binds to sensing molecules placed on the device's surface, this alters the path of light travelling through the medium, changing its "refractive index." More




Scientists Work Toward Storing Digital Information in DNA
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Her computer, Karin Strauss says, contains her "digital attic" — a place where she stores that published math paper she wrote in high school, and computer science schoolwork from college. She'd like to preserve the stuff "as long as I live, at least," says Strauss, 37. But computers must be replaced every few years, and each time she must copy the information over, "which is a little bit of a headache." It would be much better, she says, if she could store it in DNA — the stuff our genes are made of. More


Scientists Harness CO2 to Consolidate Biofuel Production Process
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Carbon dioxide (CO2) has emerged as a secret ingredient in the recipe for making ethanol, and that addition represents a major step forward in streamlining the biofuel production process. The innovation comes from researchers at the Department of Energy's Lawrence Berkeley National Laboratory and Sandia National Laboratories working at the Joint BioEnergy Institute (JBEI). The scientists have demonstrated that adding carbon dioxide gas during the deconstruction phase of biofuel production successfully neutralized the toxicity of ionic liquids. More


Could Antibiotics Be a Potential New Treatment Strategy for Alzheimer's?
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The association between the human microbiome and overall general health becomes stronger with each passing day. Specifically, evidence uncovering the influence gut microbiota exert on seemingly disparate biological pathways, such as the brain and nervous system, has become an exciting area of scientific study. Now researchers at the University of Chicago have published new findings that show long-term treatment with broad-spectrum antibiotics decreased levels of amyloid plaques — a hallmark of Alzheimer's disease — and activated inflammatory microglial cells in the brains of mice. More


Protein Stays Stable Without Its Charges
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Charge is a fundamental factor that helps dictate a protein's structure and activity. Five out of the 20 amino acids commonly found in proteins are either positively or negatively charged under physiological conditions, and all known soluble proteins have at least a few of these residues. Now, in a surprising twist, researchers have mutated a protein to remove its charged amino acids and found that the protein retains its structure, solubility and activity. More


Career


Automation Engineer, Next Generation Sequencing
Roche Diagnostics
US – MA – Boston

The Klein Endowed Chair in Alzheimer's Disease and Neurodegeneration Research
Rutgers Brain Health Institute
US – NJ – Piscataway

Field Automation Scientist, Next Generation Sequencing
Roche
United States (Virtual Work Location)

Search Jobs at SLAS Career Connections


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