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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit July 30, 2014    SLAS2015    Moving? New job? Let SLAS know.    





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JALA August Podcast on Cell-Free Protein Synthesis
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University of Florida authors Kirsten Jackson and Z. Hugh Fan discuss their JALA original report, "Cell-Free Protein Synthesis in Miniaturized Array Devices and Effects of Device Orientation," in a new podcast at JALA Online.

"As a result of this study," (which is featured on the cover of the August issue of JALA), "we found that the optimized vertically oriented continuous exchange format device increased protein expression 406% compared to the horizontal orientation," explains Jackson.

To access this article and more, view the JALA August Table of Contents.

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SLAS ELN Reports: Cynthia Yin — Greeting a Bright Future in Science
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Recent high school graduate Cynthia Yin is a well-rounded student who has a great mind for science, a gift for music and a mean game of golf.

This class valedictorian excels in many areas of life and has a wall of awards to prove it, including an SLAS Tony B. Academic Travel Award. This fall, she heads to Stanford University to pursue degrees in engineering and science.

Read more about her plans in the SLAS Electronic Laboratory Neighborhood e-zine feature article.

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JBS August: Discovery of Therapeutic Deubiquitylase Effector Molecules — Current Perspectives
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A team from Pennsylvania-based Progenra analyzes methodologies, available platforms and strategies related to deubiquitylases in this review article featured on this issue’s cover.

Original research articles in the August issue include: "Discovery of Small-Molecule Glucokinase Regulatory Protein Modulators That Restore Glucokinase Activity," "Development of a Kinetic Assay for Late Endosome Movement" and "Integrating High-Content Analysis into a Multiplexed Screening Approach to Identify and Characterize GPCR Agonists."

Ingber Presents 2014 Graeme Clark Oration
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SLAS2015 Keynote Speaker and Wyss Institute Founding Director Donald Ingber shared the history and latest developments in organs-on-a-chip in his June 5 public presentation, "The Next Technology Wave: Biologically Inspired Engineering."

Ingber wowed the audience with how technology has changed medicine and science over the last 50 years.

"We've begun to understand how nature builds, controls and manufactures from the nanoscale and up," Ingber states. "Therefore, we're going to leverage our understanding of biological principles and we're going to apply them to develop new engineering innovations."


Going Green at SLAS2015!
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SLAS is making a more concerted effort to improve sustainable, eco-friendly and socially responsible practices at SLAS2015, Feb. 7-11 in Washington, D.C.

Initiatives include decreasing use of natural resources, donating surplus materials and food to worthy local causes, enhancing recycling and repurposing of reusable materials and working with conference partners and providers who do the same.

Reminder: Biosensing Technologies Manuscript Proposals Due Aug. 1
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Two days remain to submit your abstract for consideration for the JALA Special Issue on New Developments in Biosensing Technologies. Guest Editor Xianting, Ph.D., of Shanghai Jiao Tong University in China advises that invited authors will be notified by Aug. 8. More

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    Approaches to Finding Good Hit Compounds 'The Old and the New' — Part One
    Select Science    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Peter Simpson, Journal of Laboratory Automation Reviews Editor, recently wrote an article in Nature on the different aspects of "lead" generation in drug discovery. From various meta-analyses that have been published over recent years, conventional wisdom seems to have come round to the view that high throughput screening has "failed" in its promise of delivering better, faster medicines by rapid identification of good chemical starting points. More

    NIH Scientists Find 6 New Genetic Risk Factors for Parkinson's
    National Institutes of Health    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Using data from over 18,000 patients, scientists have identified more than two dozen genetic risk factors involved in Parkinson's disease, including six that had not been previously reported. The study, published in Nature Genetics, was partially funded by the National Institutes of Health and led by scientists working in NIH laboratories. More

    Strategies and Tools to Develop a Better GPCR Targeted Therapeutic
    Multispan, Inc.     Share   
    GPCRs are one of the most pharmacologically successful drug targets with 26% of all drugs against this class1. GPCR-targeted therapeutics continues to be successful and in fact, 19% of newly approved drugs target GPCRs. The early generation of small molecule drugs targeted either orthosteric agonist or antagonist activity of these receptors’ G-protein signaling pathway. In recent years, we have discovered more about GPCRs including crystal structures, improvements in ligand design, differences in the signaling pathways and as well as how these receptors dimerize. More
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    Synthesis and Folding of a Mirror-Image Enzyme Reveals Ambidextrous Chaperone Activity
    Proceedings of the National Academy of Sciences    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Mirror-image proteins (composed of D-amino acids) are promising therapeutic agents and drug discovery tools, but as synthesis of larger D-proteins becomes feasible, a major anticipated challenge is the folding of these proteins into their active conformations. In vivo, many large and/or complex proteins require chaperones like GroEL/ES to prevent misfolding and produce functional protein. The ability of chaperones to fold D-proteins is unknown. More

    Scientists ID New Mechanism of Drug Resistance
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Microorganisms like bacteria and fungi can evade treatment by acquiring mutations in the genes targeted by antibiotics or antifungal drugs. These permanent mutations were once thought to be the only way for drug-resistant strains to evolve. Now a new study has shown that microorganisms can use a temporary silencing of drug targets — known as epimutations — to gain the benefits of drug resistance without the commitment. More

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    Effects of Atomic Geometry and Electronic Structure of Platinum Surfaces on Molecular Adsorbates Studied by Gap-Mode SERS
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Surface enhanced Raman scattering (SERS) spectra of organic monolayers were measured on various types of polycrystalline and single crystalline Pt substrates with nanometric or atomic surface features, including heteroepitaxial Pt monolayers, using sphere-plane type nanogap structures. Although atomic geometry and electronic structures of a metal surface significantly influence metal–molecule interactions, such effects are often hindered in conventional SERS measured on a roughened surface because of the spectral information averaging at various adsorption sites. More

    New Molecule Puts Scientists a Step Closer to Understanding Hydrogen Storage    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Australian and Taiwanese scientists have discovered a new molecule which puts the science community one step closer to solving one of the barriers to development of cleaner, greener hydrogen fuel-cells as a viable power source for cars. Scientists say that the newly-discovered "28copper15hydride" puts us on a path to better understanding hydrogen, and potentially even how to get it in and out of a fuel system, and is stored in a manner which is stable and safe — overcoming Hindenburg-type risks. More

    Gram-Scale Synthesis of 2-Dimensional Polymer Crystals and Their Structure Analysis by X-Ray Diffraction
    Nature Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The rise of graphene, a natural two-dimensional polymer with topologically planar repeat units, has challenged synthetic chemistry, and has highlighted that accessing equivalent covalently bonded sheet-like macromolecules has, until recently, not been achieved. Here we show that non-centrosymmetric, enantiomorphic single crystals of a simple-to-make monomer can be photochemically converted into chiral 2DP crystals and cleanly reversed back to the monomer. More

    Direct Transformation of Edible Vegetable Waste into Bioplastics
    Macromolecules    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Bioplastics with a wide range of mechanical properties were directly obtained from industrially processed edible vegetable and cereal wastes. As model systems, we present bioplastics synthesized from wastes of parsley and spinach stems, rice hulls, and cocoa pod husks by digesting in trifluoroacetic acid, casting and evaporation. In this way, amorphous cellulose-based plastics are formed. More

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