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SLAS
SLAS invites research scientists, engineers, academics and business leaders to submit abstracts for consideration to SLAS2019. The deadline for podium abstracts, SLAS Innovation Award submissions and SLAS Tony B. Academic Travel Award applications (for podium presenters) is Monday, Aug. 6. Learn more: consider contributing your novel research to one of 10 educational tracks to be offered at SLAS2019 that include topic areas such as High Definition Biotechnology, Advances in Bioanalytics and Biomarkers, Assay Development and Screening, Automation and High-Throughput Technologies and Biologics Discovery, to name a few.
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SLAS
A new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry (HTFC) in drug discovery. Led by Guest Editors Mei Ding, Ph.D. (AstraZeneca, Gothenburg, Sweden) and Bruce S. Edwards, Ph.D. (University of New Mexico, Albuquerque, NM, USA), this special issue presents a range of research papers, application notes and technical notes that reflect recent advances in HTFC methods design, provide new expert insight and perspectives, and highlight areas for improvement to broaden the range of HTFC applications in drug discovery. Image Credit: Alexandre Chigaev, University of New Mexico.
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SLAS
"The metrics that define a great conference for me are whether I meet new people, engage with known colleagues and learn something new," says SLAS President Sabeth Verpoorte, Ph.D., celebrating the successful conclusion of the recent 2018 SLAS Europe Conference and Exhibition held in June in her "backyard" of Brussels, Belgium. In a new column in the SLAS Electronic Laboratory Neighborhood, Verpoorte says, "With the conference held right in the center of the city and the perfect weather, the networking was enjoyable and interesting. You could spend time with colleagues old and new at the little cafés or pubs in the market square. When you are in Europe, it always feels a bit different; you have a bit more history around you."
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SLAS
Coleman Murray, Ph.D., University of California, Los Angeles, talks about his contribution to the August 2018 special issue of SLAS Technology on Enabling Technology in Cell-Based Therapies, by guest editor Chris Puleo, Ph.D., and his associates at General Electric Global Research. Murray’s article illustrates an important example of how new technologies are changing automation and processing in cell therapy manufacturing.
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SLAS
Gain insights on biologics and new modalities at the inaugural 2018 SLAS Americas Sample Management Symposium: Managing Samples from Bench to Clinic, Nov. 13-14, Boston, MA, USA. Join Jennifer Moore, Ph.D., director of stem cell services and technologies at RUCDR Infinite Biologics (New Brunswick, NJ, USA), as she delves into how her group developed a high-throughput, cost effective workflow for generating human induced pluripotent stem cells (hiPSC) and uses CRISPR-Cas9 to create isogenic cell lines. Also on the program: Genentech's Kristen Nailor discussing "Optimization of Nucleic Acid Sample Management Strategies to Increase Efficiency and Ensure High Quality Deliverables," and GSK's Robert Perkinson, M.Sc., exploring "Challenges and Opportunities in Automating Biological Sample Inventories." Read the complete scientific program! Poster abstracts being accepted until Monday, Aug. 27. Register before Monday, Oct. 1 to save $150. Hotel rooms are filling up for this event! The group rate is offered based on availability at the Omni Parker House hotel. Reserve early if you plan to attend!
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Journal of the American Chemical Society
Native chemical ligation (NCL) combined with desulfurization chemistry has revolutionized the way in which large polypeptides and proteins are accessed by chemical synthesis. Herein, we outline the use of flow chemistry for the ligation-based assembly of polypeptides. We also describe the development of a novel photodesulfurization transformation that, when coupled with flow NCL, enables efficient access to native polypeptides on time scales up to 2 orders of magnitude faster than current batch NCL–desulfurization methods.
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Chemical & Engineering News
Millions of tiny bubbles, released from cells and packaged with molecular mail, are racing through your bloodstream right now. And until recently, only a handful of researchers gave them any thought.
Stephen J. Gould is one of those scientists. For more than a decade, Gould has devoted significant time and resources to understanding the curious cellular couriers. Called exosomes, these lipid vesicles shuttle proteins and genetic information between both neighboring and distant cells.
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Laboratory Equipment
Despite high hopes and high investment in CRISPR-Cas9 gene editing, scientists still have a lot to learn about how it works in humans.
In the latest example, University of California, Berkeley, scientists found that people's assumptions about how cells repair the genome after the Cas9 enzyme snips DNA are wrong.
The discovery gives insight into why CRISPR-Cas9 gene editing works remarkably well in nearly every cell attempted, though not with equal success in all cells.
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Phys.org
A new tool is drastically changing the face of chemical research — artificial intelligence. In a new paper published in Nature, researchers review the rapid progress in machine learning for the chemical sciences.
Almost every technological advance in human history is accompanied by the discovery or development of new materials, from the blending of copper and zinc to form bronze to the fabrication of high-quality silicon microchips that power digital technology.
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Science Daily
Sometimes, when experimental scientists get their hands on a supercomputer, it can change the course of their careers and open up new questions for exploration.
This was the case with Abdurrahman and Tülay Atesin, husband and wife chemists, collaborators and professors at the University of Texas Rio Grande Valley. Experimentalists by training, when they moved to Texas in 2013, a colleague told them that through the University of Texas Research Cyberinfrastructure initiative they had free access to some of the advanced computing systems in the world at the Texas Advanced Computing Center (TACC).
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Lab Manager
Scientists from NUST MISIS (Moscow, Russia) and colleagues from the University of Bayreuth (Germany), the University of Münster (Germany), the University of Chicago (U.S.), and Linköping University (Sweden) have created nitrides, a material previously considered impossible to obtain. More amazing, they have shown that the material can be obtained using a very simple method of direct synthesis. Articles about the research results have been published in Nature Communications and Angewandte Chemie International Edition.
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Science Magazine
Researchers in Japan announced the launch of a clinical trial to treat Parkinson's disease with neurological material derived from induced pluripotent stem (iPS) cells, mature cells chemically manipulated to return to an early stage of development from which they can theoretically differentiate into any of the body's specialized cells. The study team will inject dopaminergic progenitors, a cell type that develops into neurons that produce dopamine, directly into a region of the brain known to play a key role in the neural degeneration associated with Parkinson's disease.
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Genetic Engineering & Biotechnology News
For many patients diagnosed with cancer, hair loss is often an inevitable consequence of various therapeutic interventions. Yet, what if instead of worrying about trying to abolish the negative hair loss side-effect of cancer therapies, scientists were able to exploit hair-loss genetics to improve the new wave of immunotherapy compounds. Well, that is exactly what a group of investigators at Columbia University Irving Medical Center (CUIMC) have accomplished.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship, or post-doc opportunity. SLAS Premier Members get a discount on all new job postings.
Research Analyst I (Biomedical Informatics)
Vanderbilt Health
US – TN – Nashville
Research Assistant I-PMI
Vanderbilt Health
US – TN – Nashville
Medical Laboratory Scientist
Fairbanks Memorial Hospital
US – AK – Fairbanks
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