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SLAS welcomes new Special Interest Group
SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
What began as a LinkedIn community of global researchers discussing topics related to phenotypic drug discovery research has developed into an SLAS Special Interest Group. The LinkedIn SLAS subgroup grew from zero to 300 in about two months. The new Phenotypic Drug Discovery SIG currently is planning its first in-person meeting for Wednesday morning, Jan. 16, at SLAS2013 in Orlando, Fla. More

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Ali Khademhosseini Sets a Pace for Tissue Engineering
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"We've really utilized the best work from researchers in different disciplines and combined them to address problems," Khademhosseini says of his laboratory's work in tissue engineering. "The best electrical engineers, chemical engineers, mechanical engineers and biologists are integrating their efforts." Read more about this 2010 SLAS Innovation Award winner, including recent efforts to construct microparticles using a micromold that changes shape in response to temperature. More

LabAutopedia August video: '7 Minutes of Terror'
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This fascinating video produced by NASA explains how they developed a highly complex, solely computer-controlled operation to get the Mars rover from the top of the atmosphere to the surface of Mars. Tom Rivellini, a NASA engineer says in the video, "If any one thing doesn't work just right, it's game over." This operation was conducted successfully this week. More



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SLAS2013 call for abstracts yields 65 percent increase in submissions
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The SLAS2013 Annual Conference Scientific Program Committee is hard at work reviewing the record-high number of abstracts received for possible podium presentation at SLAS2013, Jan. 12-16 in Orlando, Fla. The best will be selected to complete the conference program that is organized into seven tracks: Assay Development and Screening; Bioanalytical Techniques; Diagnostics; Drug Target Biology; High-Throughput Technologies; Informatics; and Micro/Nano Technologies. Watch the website for the final schedule. More

New manuscripts posted at JBS Online
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"Theoretical and Experimental Relationships between Percent Inhibition and IC50 Data Observed in High-Throughput Screening," "Novel Stem Cell–Based Drug Discovery Platforms for Cardiovascular Disease" and "Screening for Inhibitors of an Essential Chromatin Remodeler in Mouse Embryonic Stem Cells by Monitoring Transcriptional Regulation" are among the new manuscripts available only to SLAS Biomolecular Sciences Section members ahead of print. More


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NASA Mars curiosity rover lands: What's next?
The Washington Post    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The Mars rover Curiosity has successfully landed on the surface of the Red Planet. the mission concluded in the early hours of Monday morning, with touchdown occurring at 1:32 a.m. ET. NASA's rover Curiosity touched down deep in a Martian crater after a picture-perfect descent and landing, beginning what promises to be one of the most ambitious planetary missions in history. More

Crystallization-induced asymmetric synthesis of nonracemic platinum(IV) polysulfide tris(chelate) complexes
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Asymmetry of molecules can make the difference between a drug and a poison. It is therefore vital to control this parameter in synthesis. Polish researchers found how stirring a reaction mixture in the presence of suitable seeding crystals can strongly affect the products. They report their findings in the European Journal of Inorganic Chemistry. More

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Researchers invent new tool to study single biological molecules
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
By blending optical and atomic force microscope technologies, Iowa State University and Ames Laboratory researchers have found a way to complete 3-D measurements of single biological molecules with unprecedented accuracy and precision. Existing technologies allow researchers to measure single molecules on the x and y axes of a 2-D plane. The new technology allows researchers to make height measurements down to the nanometer without custom optics or special surfaces for the samples. More

Critical tumor suppressor identified
Drug Discovery & Development    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists have identified a protein that impairs the development and maintenance of lymphoma, but is repressed during the initial stages of the disease, allowing for rapid tumor growth. While the study largely focuses on the role of this new tumor suppressor in lymphoma induced by Myc oncoproteins, the authors show this circuit is apparently operational in all human tumors with MYC involvement. More


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Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody
Proceedings of the National Academy of Sciences    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The constant heavy chain domain affects antibody affinity and fine specificity, challenging the paradigm that only variable regions contribute to antigen binding. To investigate the role of the CH1 domain, we constructed IgA2 from the broadly neutralizing anti–HIV-1 2F5 IgG1, and compared 2F5 IgA2 and IgG binding affinity and functional activities. More

Analytical methods for characterizing magnetic resonance probes
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The efficiency of Gd(III) contrast agents in magnetic resonance image enhancement is governed by a set of tunable structural parameters. Understanding and measuring these parameters requires specific analytical techniques. This feature describes strategies to optimize each of the critical Gd(III) relaxation parameters for molecular imaging applications and the methods employed for their evaluation. More



Why the AIDS vaccine remains elusive
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The Cold War arms race is a great metaphor for how the AIDS virus infects people, says Barton Haynes, M.D., director of the Duke Human Vaccine Institute at Duke University School of Medicine. While the Cold War is history, the quest for a vaccine against HIV continues — an often-elusive goal that now offers some glimmers of hope. More

A case study: Possible hydrogen fluoride exposure
Central Science (blog)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
How would you have handled this situation? Three chemists in a small laboratory were moving some old chemicals to a staging area prior to disposal. Many of the chemicals were simply unopened expired reagents, while others had been previously opened and used. After perhaps a half hour of moving chemicals, one of the workers complained of a severe burning sensation on the palm of his hand. More


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Direct fluorescence monitoring of the delivery and cellular uptake of a cancer-targeted RGD peptide-appended naphthalimide theragnostic prodrug
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Presented here is a multicomponent synthetic strategy that allows for the direct, fluorescence-based monitoring of the targeted cellular uptake and release of a conjugated therapeutic agent. Specifically, we report here the design, synthesis, spectroscopic characterization, and preliminary in vitro biological evaluation of a RGD peptide-appended naphthalimide pro-CPT (compound 1). More

Extreme plasma theories put to test
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The first controlled studies of extremely hot, dense matter have overthrown the widely accepted 50-year-old model used to explain how ions influence each other's behavior in a dense plasma. The results should benefit a wide range of fields, from research aimed at tapping nuclear fusion as an energy source to understanding the inner workings of stars. The study also demonstrates the unique capabilities of the Linac Coherent Light Source X-ray laser. More

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Researchers find cattle vaccine works to reduce E. coli
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A commercial vaccine for cattle can effectively reduce levels of E. coli by more than 50 percent, a Kansas State University study has found. The vaccine is also effective using two doses instead of the recommended three doses, which can help cut costs for the beef industry. David Renter, associate professor of epidemiology, is the principal investigator on a project that researched the effectiveness of products used to prevent the shedding of E. coli O157:H7 in cattle. More

Free video series explores crystallization's benefits
METTLER TOLEDO    Share    Share on FacebookTwitterShare on LinkedinE-mail article
METTLER TOLEDO offers brief videos to help prospective users visualize the benefits of using process analytical technology to improve crystallization for enhanced control of critical process parameters. The videos are "Understand Your Crystallization Process," "Transfer Your Crystallization Process," "Optimizing Your Crystallization Process" and "The Crystallization Workstation." More


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Career


Sensor Technology for Plant Phenotype Characterization
Washington State University
USA – WA – Pullman

Bioscience Engineer
Douglas Scientific
USA – MN – Alexandria

Co-director, Center for Research on Textile Protection and Comfort and Faculty Position
North Carolina State University
USA – NC – Raleigh

More jobs at SLAS Career Connections


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