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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit August 9, 2017    SLAS2018    Moving? New job? Let SLAS know.      







SLAS Webinar on 3-D Assays: Sept. 26
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Brad Larson of BioTek Instruments and Mark Rothenberg of Corning Life Sciences share their expertise on the cellular microenvironment and its importance when developing and screening cell-based assays using primary, stem cell and immortalized cultures in 3-D systems.

"3-Dimensional Assays: What Must Be Done for Setting Up and Validating for Downstream Microplate Reader and Imaging Applications" will be presented live Sept. 26 and then available on demand. Read more about the topic in the SLAS Discovery Special Issue on 3-D Cell Culture, Drug Screening and Optimization (featuring free access to select articles courtesy of Corning) and the SLAS Electronic Laboratory Neighborhood feature article. Register today!


Advance Your Professional Success: Publish in SLAS Journals
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SLAS Discovery and SLAS Technology welcome manuscript submissions on an ongoing basis from SLAS members and non-members. Backed by the world-class education standards of SLAS, submissions are rigorously peer-reviewed and there are no article processing charges (APCs). Open access options are available.

SLAS journals address the full spectrum of issues that are mission-critical to life sciences professionals, enabling research teams to gain scientific insights; increase productivity; elevate data quality; reduce process cycle times; and enable research and development that otherwise would be impossible.

SLAS Europe Council Seeks Candidates: Respond by Aug. 28
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Individuals who wish to serve on the SLAS Europe Council are invited to submit materials for consideration by midnight CET, Monday, Aug. 28. Nomination materials include a short statement of your reasons for seeking a position, current CV and an affidavit acknowledging your eligibility to serve.

The current SLAS Europe Council will review submitted materials and select a slate to fill two open positions on the Council; the proposed slate will be presented to all SLAS Europe region dues-paying members in September. The new Council members will replace Marc Bickle and Katy Kettleborough, whose terms expire in 2017.

Improve high-throughput Fragment Analysis

Accelerate your high-throughput DNA fragment analysis with the ZAG DNA Analyzer from Advanced Analytical. With the ZAG, you can separate up to 48, 96-well sample plates every 24 hours, providing you with the results you need, when you need them. Find out why the ZAG is perfect for you.

Micro- and Nanotechnologies at SLAS2018, Feb. 3-7, San Diego
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This track encompasses new and emerging technologies including microfluidics, microarrays, microreactors, nanodevices and nanotechnologies with emphasis on methods and materials applicable to high-throughput chemistry, high-content screening, point-of-care diagnostics, biology and clinical analysis.

Track sessions include "Commercialization of Micro and Nano-fluidic Devices," "Droplet-Based Microfluidics and Single-Cell Analysis" and "Organ-on-a-Chip and Microphysiological Systems." Micro- and Nanotechnologies Track chairs are Andrew deMello of the Institute for Chemical and Bioengineering and Sammy Datwani of Labcyte. For more information about this track and nine others, visit the SLAS2018 website.

NEW from the Cravatt Lab: 'Ligand and Target Discovery by Fragment-Based Screening in Human Cells'
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SLAS2018 keynote presenter Benjamin F. Cravatt's team recently published the paper in Cell. It describes "a platform that marries fragment-based ligand discovery with quantitative chemical proteomics to map thousands of reversible small molecule-protein interactions directly in human cells, many of which can be site-specifically determined. We show that fragment hits can be advanced to furnish selective ligands that affect the activity of proteins heretofore lacking chemical probes. We further combine fragment-based chemical proteomics with phenotypic screening to identify small molecules that promote adipocyte differentiation by engaging the poorly characterized membrane protein PGRMC2."

Cravatt addresses SLAS2018 on Monday morning, Feb. 5, San Diego.



New Approach Makes It Easier to Find Novel Drugs
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Scientists have created a new way of screening compounds that is more sensitive than existing methods, opening up the possibility of finding new drugs for many diseases. The researchers, from the Francis Crick Institute and University of Manchester, hope that their new technique will help to speed up drug development and find new uses for existing drugs and other compounds present in pharmaceutical libraries. Their findings are published in Nature Communications. More

CRISPR Corrects Mutation in Human Embryos
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For the first time in the U.S., researchers have used the CRISPR-Cas9 gene-editing system in human embryos to correct a harmful hereditary gene mutation. Led by Shoukhrat Mitalipov of Oregon Health & Science University, the team injected eggs from healthy donors with sperm from a donor with hypertrophic cardiomyopathy, a common condition characterized by irregular heartbeat and heart failure. People with the disease carry a mutation in one of two copies of their MYBPC3 gene. More

Sponsored Content

Deposition of a Sorbent into a Recession on a Solid Support to Provide a New, Mechanically Robust Solid-Phase Microextraction Device
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To date, solid-phase microextraction (SPME) fibers used for in vivo bioanalysis can be too fragile and flexible, which limits suitability for direct tissue sampling. As a result, these devices often require a sheathing needle to prepuncture robust sample matrixes and protect the extraction phase from mechanical damage. To address this limitation, a new SPME device is herein presented which incorporates an extraction phase recessed into the body of a solid needle. More

CRISPR Screen Identifies Top 100 Essential Genes for Cancer Immunotherapy
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Existing cancer immunotherapies harness T cells that recognize and home in on tumor-specific targets and kill the cancer cells. Immunotherapy using checkpoint inhibitors, for example, disconnects immune system restraints so that the T cells can attack the cancer cells. Other forms of immunotherapy, including cancer vaccines and adoptive T-cell therapy, increase the numbers of cytotoxic T cells that are mobilized to the tumor. More

KMC Systems Engineering & Manufacturing

KMC Systems is a leading provider of engineering services and contract manufacturing for the development, design and production of medical and life sciences instrumentation. We specialize in developing mechanized processes for tightly controlled and highly automated systems and manufacturing complex, highly-regulated instruments for the clinical environment.

Methane Oxidation to Methanol Catalyzed by Cu-Oxo Clusters Stabilized in NU-1000 Metal—Organic Framework
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Copper oxide clusters synthesized via atomic layer deposition on the nodes of the metal–organic framework (MOF) NU-1000 are active for oxidation of methane to methanol under mild reaction conditions. Analysis of chemical reactivity, in situ X-ray absorption spectroscopy, and density functional theory calculations are used to determine structure/activity relations in the Cu-NU-1000 catalytic system. More

Researchers Develop Technology to Make Aged Cells Younger
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Aging. We all face it. Nobody's immune and we've long tried to reverse it, stop it or just even slow it down. While advances have been made, true age-reversal at a cellular level remains difficult to achieve. By taking a different approach, however, researchers at Houston Methodist made a surprising discovery leading to the development of technology with the ability to rejuvenate human cells. And that couldn't be more important for the small population of children who are aging too quickly — children with progeria. More

Researchers Describe Protein Previously Unknown in Biology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
University of Georgia researchers have discovered a new way that iron is stored in microorganisms, a finding that provides new insights into the fundamental nature of how biological systems work. The research was recently published in the journal Nature Communications. Iron, a metal that is required by all living organisms, is usually stored with oxygen inside a cell in a complex within a large protein known as ferritin. More

Marriage of Microscopy Techniques Reveals 3D Structure of Critical Protein Complex
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Researchers at the Stowers Institute for Medical Research have solved the three-dimensional structure of a complex that is essential for the correct sorting of chromosomes into eggs and sperm during reproductive cell division or meiosis. When this structure, called the synaptonemal complex, doesn't assemble properly in the cell, it can lead to chromosomal abnormalities, miscarriages, and birth defects. More


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New York Genome Center
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US – MO – St. Louis

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