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SLAS
In a new article in the SLAS Electronic Laboratory Neighborhood (SLAS ELN), Bernard Fermini, Ph.D., discusses Clinical Trials in a Dish (CTiD) studies, a strategy to identify drugs with higher probabilities for clinical success early in the development process. CTiD allows for laboratory testing medical therapies for safety or efficacy on cells collected from a representative sample of human patients before moving into actual clinical trials. "Not only are we contributing by reducing the cost of drug development, but we're redirecting the efforts of some of the smartest people in the industry to work on drugs that will actually succeed," says Fermini, a lead author of a recent SLAS Discovery article regarding CTiD and the chief scientific officer and vice president of safety and toxicology assessment at Coyne Scientific (Atlanta, GA, USA).
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SLAS
Communicate your innovative ideas to interested colleagues at the 2018 SLAS Americas Sample Management Symposium, Managing Samples from Bench to Clinic, Nov. 13-14, Boston, MA, USA. Poster presentations allow for one-on-one discussion and open doors for future collaboration. Submit an abstract for consideration by Monday, Aug. 27. View the complete scientific program! Register before Monday, Oct. 1 to save $150. Discounted registration available for students. Hotel rooms are filling up for this event! The group rate is offered based on availability at the Omni Parker House. Reserve early if you plan to attend!
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SLAS
ScholarOne Manuscripts (a.k.a. SLAS Discovery and SLAS Technology SAGE Track) has transitioned to Amazon Web Services. To ensure uninterrupted e-mail delivery, please have your IT team whitelist these domains — amazonses.com and manuscriptcentral.com — to your Safe Senders List.
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SLAS
See what's new in Molecular Libraries, one of 10 tracks to be offered at SLAS2019. Examine strategies for library utility and discover the science of developing and leveraging small molecule libraries for hit identification and target validation. Also explore the outer fringes of the small molecule world, including the use of macromolecules, natural products and macrocycles. Planned sessions include: small molecule libraries used for high-throughput screening, the utility of DNA-encoded libraries for hit identification and specialty libraries at the edge of the chemical space normally associated with screening collections. Submit a poster abstract to one of the 10 tracks today! Students: Apply for an SLAS Tony B. Academic Travel Award when you submit a poster abstract by Monday, Sept. 24. Submit your work to be considered for the SLAS Student Poster Competition by Monday, Oct. 29.
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SLAS
SLAS Membership connects you to the highly collaborative community of more than 18,000 life sciences researchers, scientists, engineers, innovators and entrepreneurs. SLAS members freely share their wisdom, experiences and best practices delivered through formal education and informal peer networking opportunities. Tangible benefits of SLAS Premier (dues-paying) Membership include:
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Anton Paar’s Modular Sample Processor allows pipetting, sampling, dosing and weighing to be automated. Available as a benchtop unit or a complete solution integration. MORE
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Chemical & Engineering News
Pollen, best known as an immune system irritant that elicits allergic reactions in the form of sneezes and snot, may one day bring medical treatment instead of misery. The strong shells of pollen grains don't break down on contact with enzymes in the body, and their complex shapes make them stick especially well to cells — which has made researchers wonder if pollen could deliver molecules of interest to a cell.
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Lab Manager
A comprehensive RNA and DNA sequencing platform benefits late-stage and drug-resistant multiple myeloma patients by determining which drugs would work best for them, according to results from a clinical trial published in JCO Precision Oncology in August.
The novel platform, created by Mount Sinai cancer, genomics, and precision health researchers, expands on traditional DNA-based approaches by using RNA sequencing to find targets for a broad swath of FDA-approved cancer drugs beyond those approved specifically for multiple myeloma.
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Journal of the American Chemical Society
A novel method for direct transformation of allyl groups in allylbenzene derivatives to alkenyl groups via rhodium-catalyzed C–C bond cleavage is reported. The alkenylation with styrenes of allylbenzenes containing pyridyl and pyrazolyl groups as a directing group proceeded efficiently to give alkenylation products. We also developed a new protocol for transformation of an ortho-prenylated phenol to an aniline derivative.
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Science Daily
Researchers at Tohoku University in Japan have collaborated with others to develop a simple way to create and functionalize virus-like polymer particles that have various nanostructures. The collaboration includes researchers from Michigan University in the USA and Karlsruhe Institute of Technology (KIT) in Germany. The geometrical control of enzymes, antibodies and other proteins over polymer particles is essential for realizing cascade reactions observed in a living body; highly sensitive immunoassay systems; and highly efficient drug delivery systems.
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Laboratory Equipment
A research team at the Broad Institute of MIT and Harvard, Massachusetts General Hospital (MGH) and Harvard Medical School report a new kind of genome analysis that could identify large fractions of the population who have a much higher risk of developing serious common diseases, including coronary artery disease, breast cancer or type 2 diabetes.
These tests use information from millions of places in the genome to ascertain risk for five diseases and can flag greater likelihood of developing the potentially fatal conditions well before any symptoms appear.
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Genetic Engineering & Biotechnology News
Scientists at University of Utah (U of U) Health report that they have developed high-tech tools to uncover the genetic cause of early infantile epileptic encephalopathy (EIEE). Their study ("Whole-genome analysis for effective clinical diagnosis and gene discovery in early infantile epileptic encephalopathy") appears online in Nature Genomic Medicine.
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Science Magazine
To identify a cell, researchers often have to abuse it — rip it from its home, douse it with toxic fixatives, doctor its DNA, or coerce it into making exotic proteins that could upset its biochemistry. Even if the cell survives, it may never be the same again. But a strong yet gentle beam of light could one day allow researchers to classify cells while leaving them unharmed and alive for additional study.
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Phys.org
How water solvates and transports protons is a fundamental question facing chemists and biologists alike and is vital to our understanding of processes such as photosynthesis and cellular respiration.
A team of researchers at the University of Chicago used broadband 2-D IR spectroscopy to reveal proton behavior when acids like HCl dissociate in water.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship, or post-doc opportunity. SLAS Premier Members get a discount on all new job postings.
Senior Technician – Analytics
Cellectis
FRANCE – Paris
Zebrafish Research Assistant III
Vanderbilt Eye Institute, Vanderbilt Health
US – TN – Nashville
Medical Laboratory Scientist (MLS) Educator
Fairbanks Memorial Hospital
US – AK – Fairbanks
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