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A bioluminogenic HDAC activity assay: Validation and screening
Journal of Biomolecular Screening Share
   
JBS OnlineFirst: The authors report the evaluation of homogeneous, single-addition, bioluminogenic HDAC enzyme activity assays that offer less assay interference by compounds in comparison to fluorescence-based formats.
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Mick Bhatia at SLAS Screening Stem Cells 2011
SLAS Share
The director and senior scientist at the Stem Cell and Cancer Research Institute, McMaster University, is one of 18 expert speakers at SLAS Screening Stem Cells 2011. Watch a video of his lab’s work on turning skin cells into blood.
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The Lab Man wins award
SLAS Share
SLAS' The Lab Man won the 2011 American Society of Association Executives Gold Circle Award for excellence in the podcast category. The Lab Man publishes conversations on current
topics with different laboratory science and technology professionals in his podcast and blog.
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Get results fast with Hamamatsu’s FDSS µCELL, an imaging-based microplate reader. This affordable,
simple-to-use reader accommodates 96- or 384-well microplates for kinetic cell-based assays such as GPCR, ion channel, prolyl isomerase, transporter, and light-activated receptor or channel assays. Click here for more info.
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SLAS2012 features Scripps chemist
SLAS Share
Renowned chemist Peter G. Schultz of The Scripps Research Institute offers "A Chemist's Foray into Translational Medicine" during his keynote presentation at the First Annual SLAS Conference and Exhibition in San Diego.
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What the Dog Saw: And Other Adventures
SLAS Share
SLAS Electronic Laboratory Neighborhood highlights the newest entry on the LabAutopedia book list — this engaging book by Malcolm
Gladwell.
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Apply for a Tony B. Academic Travel Award
SLAS Share
September 26 is the deadline for applications and poster abstracts for this awards program. More than 50 awards were presented in 2011. Students, graduate students, post-doctoral associates and junior faculty (less than four years in first academic appointment) are encouraged to apply.
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The Access™ laboratory workstation
transforms any Echo® liquid handler into an automated system for gene expression assays with reaction volumes as low as 250 nL. MORE |
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SLAS HTS history presentation at
ELRIG
SLAS Share
"High-Throughput Screening: Historical Success and Future Perspectives" by Stephen Rees of AstraZeneca is one of seven presentations during
the SLAS session at ELRIG Drug Discovery 2011, Sept. 7-8, Manchester Central, U.K.
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SRU Biosystems has introduced the first and only high resolution, optical, label-free plate reader.
Capable of measuring functional responses in individual cells, the SCANNER represents a new paradigm in drug discovery enabling the use of primary cells earlier in drug discovery process. Contact us to learn more.
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Ultra Low Attachment Surface plates feature a covalently bound hydrogel layer that effectively inhibits cellular attachment, minimizes protein absorption, enzyme activation, and cellular activation. Corning® introduces 384 well black clear bottom Ultra Low Attachment Surface plates for HTS applications of tumor spheroid and stem cell embryoid body screening.
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Transform uHT Screening: Replace microplates with Nexar’s in-line sample processing in Array Tape - a continuous plastic strip, serially embossed with reaction wells
Increase Throughput: Efficient, parallel processing within customized modules
Save Reagents:
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Nucleobases in meteorites hint at origins of life on Earth
National Academy of Sciences Share
Nucleobases are nitrogen-containing compounds that serve as the structural basis for information storage in RNA and DNA. Researchers have not extensively studied nucleobases in meteorites — although the presence of amino acids has been examined — and until now, all meteorite-derived nucleobases could be explained as the result of terrestrial contamination. Michael Callahan, et al., used liquid
chromatography–mass spectrometry to determine the abundance and distribution of nucleobases and their analogs in extracts from 12 meteorites.
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Direct detection of biologically significant thiols and disulfides with manganese(IV) chemiluminescence
Analytical Chemistry Share
The quantification of low-molecular mass thiols and disulfides involved in cellular redox processes is hindered by oxidation or degradation of analytes during conventional sample preparation steps (including deproteinization and derivatization). Researchers therefore seek techniques that minimize sample handling and permit direct detection of
thiols and disulfides within a single chromatographic separation.
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Drug developers bolstering quality management teams
Chemical & Engineering News Share
After waves of massive layoffs prompted in large part by the Great Recession, companies involved in drug development have been operating with bone-lean staffs over the past few years. However, drug and biotech companies have been cautious about drastically cutting staff from one area of their business — that which involves quality control and quality assurance. And now, as the regulatory environment grows
increasingly global and complex, companies are reevaluating the strength of their QC and QA ranks.
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Nature Middle
East is a FREE resource for scientists and clinicians to connect, research, network and exchange information and ideas. Sign up to the latest research coming out of the Arab world and become part of the of Nature Middle East community.
You can also follow Nature Middle East on Facebook and Twitter. |
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Turn-on DNA damage sensors for the direct detection of 8-oxoguanine and photoproducts in native DNA
Journal of the American Chemical Society Share
The integrity of the genetic information in all living organisms is constantly threatened by a variety of endogenous and environmental insults. To counter this risk, the DNA-damage response is employed for repairing lesions and maintaining genomic integrity. However, an aberrant DNA-damage response can potentially lead to genetic instability
and mutagenesis, carcinogenesis or cell death.
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Next generation: Hundreds of cell analyses at once
eBio News Share
Like a pinball machine, the tiny stationary levers within this new microfluidics chip, direct cells into compartments just large enough to fit one cell. With 300 compartments per chip (a number that could be easily scaled to 1,000 or more), each cell is washed and then lysed, with its contents channeled to a new compartment where real time quantitative PCR begins, reading out the DNA as it's amplified.
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Cellular Dynamics launches innovative research grant program
Cellular Dynamics International, Inc. Share
Cellular Dynamics International announced the recent launch of its Innovative Research Grant Program. This grant program will advance researchers' understanding of induced pluripotent stem cells, the terminal cell types derived from them, and the role and applications of this new in vitro cellular model in basic research, drug discovery and development.
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Green tea proven effective in treating genetic disorder, tumors
PhysOrg Share
A compound found in green tea shows great promise for the development of drugs to treat two types of tumors and a deadly congenital disease. The discovery is the result of research led by Dr. Thomas Smith at The Donald Danforth Plant Science Center and his colleagues at The Children's Hospital of Philadelphia. Their findings are published in the article, "Green Tea Polyphenols Control Dysregulated Glutamate
Dehydrogenase In Transgenic Mice By Hijacking The ADP Activation Site" in the Journal of Biological Chemistry.
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Blood test can
tell fetus' sex at just 7 weeks
Popular Science Share
A simple blood test can determine a baby's gender as early as seven weeks into pregnancy, a
new study says — far earlier and far less invasive than other options. The test could conceivably help parents who are worried about gender-related diseases, but it could also allow people to wade into the morally murky waters of sex selection. The test analyzes fetal DNA found in a mother's blood, according to a report in the New York Times.
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Measurements reveal extent of leakage from Japan's damaged Fukushima reactor
Science Daily Share
Atmospheric chemists at the University of California, San Diego, report the first quantitative measurement of the amount of radiation leaked
from the damaged nuclear reactor in Fukushima, Japan, following the devastating earthquake and tsunami earlier this year. Their estimate is based on a signal sent across the Pacific Ocean when operators of the damaged reactor had to resort to cooling overheated fuel with seawater.
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The Sci-Print MP2+ is a high throughput fully automated barcode printer for labeling microtiter plates and deep well blocks. Stacks can hold 50 microtiter plates and can label any or all sides of the plate. User configurable label text with multiple barcode formats. Click here to see product videos and more!
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The HTFC® Screening System from IntelliCyt is a fast, highly sensitive, and simple-to-operate multicolor platform for phenotypic screening. This automation-friendly system can analyze thousands of cells per second from 96 or 384 well microplates and create heatmap data displays to quickly visualize hits.
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The comPOUND system comprises a high-density sample storage unit and an additional suite of specialized delivery and processing modules to enable easy integration into any compound
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Affordable Benchtop Instruments:
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Nexus Biosystems- your partner in Discovery Science processes from Sample Storage to Sample Analysis Solutions.
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Venenum BioDesign specializes in HTS of 5.5
million compounds including new libraries for protein-protein interactions.
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Students, graduate students, post-doctoral associates and junior faculty may apply for a travel award.
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