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Aug. 19, 2020

SLAS NEWS

A New Job Title Every Day Depending on the day, Carine Nemr, the 2019 SLAS Graduate Education Fellowship winner, could hold the title of bioengineer, chemist, teacher – or a wide variety of related jobs. In the latest New Matter: Inside the Minds of SLAS Scientists podcast she discusses lab training, microfluidics, antibiotic resistance and how important networking is to finding the perfect career(s). LISTEN NOW

Ignite Your Research with a Live Talk or Poster Presentation During SLAS2021 Digital SLAS The shift to a digital format for SLAS2021 has begun, as has the submission period for live talk and poster abstracts. Start prepping your research for your chance to be a part of the SLAS2021 Digital International Conference and Exhibition (January 25-27, 2021). While the experience may be a bit different, the opportunities to be recognized for significant research are the same. Poster presenters will have the opportunity to upload audio/video presentations and answer questions from participants! See below for links to important call for abstracts info, including the coveted Innovation Award with its dedicated presentation times, and Tony B. Academic Travel Award, which will provide opportunities for recognition without the hotel stay and airfare. Deadlines below: Podium abstract submission deadline: Monday, September 14 Tony B. Academic Travel Award podium submission deadline: Monday, September 14 Tony B. Academic Travel Award poster submission deadline: Monday, October 5 Poster abstract submission deadline: Monday, October 19 VIEW COMPLETE CALL FOR ABSTRACTS DETAILS

Sponsors and Exhibitors: Bookmark this Important FAQ Page SLAS Keep current with the latest sponsor and exhibitor news by visiting the FAQ page on the SLAS2021 Digital website. Topics include current sponsor and exhibitor options plus a timeline of what to expect with regards to upcoming updates and deadlines. In addition, this page will host the Digital Prospectus starting in late-September. We’re excited to unveil a diverse line-up of promotional opportunities that could earn you the visibility you’re looking for from the SLAS community. VIEW UP-TO-DATE SPONSOR AND EXHIBITOR DETAILS

'Meet' the WomXn in SLAS SLAS Connect “face-to-face” with the new WomXn in SLAS SIG at the next SLAS Member Meet-Up on Wednesday, August 26. The SIG is open to all womXn and those supportive of womXn in various roles in the SLAS community. SLAS will host a special online meet-up hosted by WomXn in SLAS SIG Co-Chairs Ginger Cooper (Agilent) and Debbie Bowers (BioSoft Integrators, Inc.) and moderated by SLAS Board Member Michelle Arkin, Ph.D., (UCSF) from 11:00 a.m. - 12:00 p.m. CDT. Registration is now open for what will be a well-rounded discussion on what it means to be a womxn in the various STEM fields. REGISTER NOW

SPONSORED VIDEO The Ultimate Laboratory Microplate Mover The Thermo Scientific™ Orbitor™ RS2 microplate mover is a collaborative bench-top mover that provides unbeatable reliability and improved process efficiency. It’s innovative bi-directional telescoping arm coupled with it’s expansive 360° workspace provide exceptional reach and precision, making the Orbitor RS2 your trusted laboratory productivity partner. WATCH VIDEO

Save the Date for September's Webinar Series on Cancer Research and Drug Discovery SLAS Beginning September 10, SLAS will offer a three-part series spanning important cancer drug discovery topics like the use of 3D cellular models in pre-clinical testing and drug screening, and how patient derived scaffolds can be used to simulate microenvironments. Thursday, September 10, 7:00 a.m. CDT: Redefining Pre-Clinical Testing in Oncology: Why We Need to Go 3D Tuesday, September 15, 7:00 a.m. CDT: The Roadmap for the Next Generation Oncology: The Contribution of Tridimensional Models Tuesday, September 22, 7:00 a.m. CDT: Patient Derived Scaffolds (PDS) in Cancer Research and Drug Discovery All times are CDT and each webinar lasts one hour. Registration is FREE for SLAS members and $20 each for all others. REGISTER NOW

Programming Note: August's Live Webinar on Homogeneous Proximity Postponed SLAS The upcoming webinar, “Compound-Mediated Interferences in Homogeneous Proximity Assays” hosted by Jayme L. Dahlin, M.D., Ph.D., (Brigham and Women’s Hospital) on Thursday, August 27 has been postponed. A new date will be announced soon!

PRODUCT SHOWCASE Accelerate biologics development Introducing the BioXp™ 3250 system, a fully automated synthetic biology workstation. It dramatically reduces the timelines for identifying antibody and vaccine candidates from weeks to days by assembling DNA clones, libraries, and gene fragments — as long as 7,000 base pairs — in a single overnight run. LEARN MORE

Two New Open Access Articles Published by SLAS Discovery and SLAS Technology SLAS Earlier this month, SLAS Discovery and SLAS Technology released two new research papers available via open access. These articles are FREE for all, have unlimited access and never expire. Dig into robust research about why the Z metric doesn’t have to be greater than 0.5 in order to perform a high-throughput assay before shifting into a report on the data related to Covance’s Xcellerate platform, a central lab data bank that houses more than 55 million test results from around the world. SLAS Discovery: Z’ Does Not Need to Be > 0.5 SLAS Technology: Xcellerate Investigator Portal: A New Web-Based Tool for Online Delivery of Central Laboratory Data, Reports, and Communications to Clinical Sites

Calendar of Important Dates SLAS SLAS2021 Digital International Conference and Exhibition January 25 – 27, 2021 Save the Date! What Does it Mean to be a WomXn of SLAS? SLAS Member Meet-Up Wednesday, August 26 11:00 a.m. CDT September Webinar Series Redefining Pre-Clinical Testing in Oncology: Why We Need to Go 3D September 10 7:00 a.m. CDT The Roadmap for the Next Generation Oncology: The Contribution of Tridimensional Models September 15 7:00 a.m. CDT Patient Derived Scaffolds (PDS) in Cancer Research and Drug Discovery September 22 7:00 a.m. CDT

SPONSORED CONTENT Promoted by Corning • Is your lab reopening? Check out these tips to keep you safe during a pandemic. • Ramping up drug, vaccine and infectivity testing with airway organoids. • 3D cell culture could drive the fight against infectious diseases • Why HUB organoids are key to advancing personalized cancer therapies • Organoid vs. spheroid: What’s the difference?

HEADLINES

Ru-Catalyzed Geminal Hydroboration of Silyl Alkynes via a New gem-Addition Mechanism Journal of the American Chemical Society While 1,2-addition represents the most common mode of alkyne hydroboration, herein we describe a new 1,1-hydroboration mode. It is the first demonstration of gem-(H,B) addition to an alkyne triple bond. With the superior [CpRu(MeCN)3]PF6 catalyst, a range of silyl alkynes reacted efficiently with HBpin under mild conditions to form various synthetically useful silyl vinyl boronates with complete stereoselectivity and broad functional group compatibility. READ MORE

Least Squares Methods for Treating Problems with Uncertainty in x and y Analytical Chemistry Methods for straight-line fitting of data having uncertainty in x and y are compared through Monte Carlo simulations and application to specific data sets. Under special circumstances, the “ignorance” methods, methods which are typically used without information about the data errors σx and σy, are equivalent to the recommended best approach. The latter is numerical rather than formulaic but is easy to implement in programs that permit user-defined fit functions. READ MORE

FEATURED ARTICLE Drug screening in patient tumor micro environment Promoted by Iscaffpharma Sortina Pharma use Iscaffpharma’s patient derived scaffolds to create drug fingerprints and select drugs for aggressive cancer. Read Case READ MORE

Characteristics That Give Viruses Pandemic Potential The Scientist Even before COVID-19 swept across the globe this year, coronaviruses were on scientists’ radar as pathogens that could one day ignite a pandemic. They’d threatened to before—in 2002–03, the SARS virus infected 8,000 people in more than two dozen countries and killed almost 800—and they checked off several specific boxes that emerging infectious disease specialists worry about in a virus. But they’re not the only group of viruses that researchers are concerned about. READ MORE

Artificial Intelligence Finds Alternative Routes to COVID-19 Drug Candidates Chemical & Engineering News Drug-repurposing studies are testing a range of compounds to treat COVID-19, but manufacturers may struggle to meet demand if any of these candidates prove effective against SARS-CoV-2. The pandemic has already strained global supply chains and limited the availability of a number of products, including hand sanitizer and diagnostic test reagents. The raw materials needed to make a new antiviral drug would most likely face similar pressures. READ MORE

PRODUCT SHOWCASE

Convenient. Consistent. Certain. Matrigel matrix-3D plates are a pre-coated, convenient, off the shelf option that improve productivity and consistency in homogenous assays where 3D structures are grown and assayed directly in the plate. Using a pre-coated option eliminates the need to handle small volume ECM dispensation and helps reduce workflow steps LEARN MORE Biospecimen Acquisition to Support Research The Cooperative Human Tissue Network (CHTN) is a unique NCI supported resource that provides human tissues and fluids prospectively from surgeries, autopsies and other routine procedures to investigators who utilize human biospecimens in their research. Visit our website for more information and pricing or contact our Central Coordinator. LEARN MORE

New Kind of Interaction Discovered in Hydrogen-Producing Enzymes Phys.org Hydrogenases can convert hydrogen just as efficiently as expensive platinum catalysts. In order to make them usable for biotechnological applications, researchers are deciphering how they work in detail. A team from Ruhr-Universität Bochum and the University of Oxford now reports in the journal Proceedings of the National Academy of Sciences that the transfer of protons and electrons by the enzyme takes place spatially separated, but is nevertheless coupled and thus, a decisive factor for efficiency. READ MORE

Extrachromosal DNA Found to Play a Critical Role in Cancer Genetic Engineering & Biotechnology News Human cells have twenty-three pairs of chromosomes but in cancer, genes can be amplified in chromosomes or in circular extrachromosomal DNA, whose frequency and functional significance are not understood. Now researchers at the University of California, San Diego, report that ecDNA is a common event in human cancer, occurring at minimum in 14% of human tumors, with higher frequencies in the most malignant forms of cancer, including glioblastoma, sarcoma, esophageal, ovarian, lung, bladder, head and neck, gastric, and many others. READ MORE

PRODUCT SHOWCASE The High Performance Microplate Solution.­ Aurora is 100% focused on making the highest quality, highest performing Microplates available. We use the best materials, the cleanest and most precise molding operations for our Microplates. We believe that the best Microplates should be an invisible carrier for your work - not a contributor to variability in your data. LEARN MORE

Novel Method Can Efficiently Create Several 'Building Blocks' of Pharmaceutical Drugs Science Daily Several drugs, including those for depression, schizophrenia, and malaria, would not be if not for a type of organic chemical compound called alicyclic compounds. These compounds are 3D structures formed when three or more carbon atoms join in a ring via covalent bonds, but the ring is not aromatic. Aromatic compounds (or arenes) are another class of organic compounds which are 2D structures with reactive properties distinct from those of alicyclic compounds. READ MORE

Researchers Discover How Enzyme Protects Cells from DNA Damage Lab Manager A research team from Mount Sinai has unraveled for the first time the three-dimensional structure and mechanism of a complex enzyme that protects cells from constant DNA damage, opening the door to discovery of new therapeutics for the treatment of chemotherapy-resistant cancers. In a study published in Nature Structural & Molecular Biology in August, the researchers described how they used advanced cryo-electron microscopy to gain detailed insights into the enzyme known as DNA polymerase ζ. READ MORE

CAREER CONNECTIONS

Job Seekers: Post your résumé and sign up for new job alerts by keyword. Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings. Scientific Director SLAS US – IL – Oak Brook Post-Doctoral Research Associate - Biochemistry/Cellular Molecular Biology Knoxvillev US – TN – Knoxville Clinical Monitor USC US – CA – San Diego Search Jobs at SLAS Career Connections

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