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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit August 20, 2014

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SLAS ELN Reports: Lorenz Mayr — Listen to the Data
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Early on in his scientific training, SLAS member and JBS Associate Editor Lorenz Mayr, Ph.D., learned to let the data speak for itself.

Be precise about interpretation, but don't over-analyze. Most importantly he learned that it is never OK to be "about right" — you have to be absolutely right before you submit work for publication.

Read more about the vice president and global head of Reagents and Assay Development at AstraZeneca in the SLAS Electronic Laboratory Neighborhood e-zine.
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JBS September Issue Now at JBS Online for Members and Subscribers
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"Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening," "Niemann–Pick Disease Type C: Induced Pluripotent Stem Cell–Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy" and "Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins" are among the original research articles in the September issue.

The Product Focus for the issue is microplates, assay reagents, screening consumables and kits.

SLAS Biomolecular Sciences Section members and JBS subscribers can view the issue online now.
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New Short Course at SLAS2015: Laboratory Statistics Fundamentals
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"Introduction of Quantitative Treatment of Biological Assays in Bioanalytical Laboratory" will be held Sunday, Feb. 8.

This SLAS2015 Short Course, one of seven new or re-engineered conference short courses, reviews statistical terms and concepts, study design, bioanalytical measurements and calculations, bioanalytical data equations, HTS data normalization and statistical testing.

Liming Shi, senior research scientist in assay development at Eli Lilly and Company, and Robert Nadon, associate professor of human genetics at McGill University and principal investigator at Genome Quebec Innovation Centre, are course instructors.

Image courtesy of Sriram Subramaniam at the National Institutes of Health.
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Hamilton Company Named SLAS2015 Premier Sponsor
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"SLAS is pleased to welcome Hamilton as our Premier Sponsor at SLAS2015," said Greg Dummer, SLAS CEO. "Hamilton's longstanding support of our Society, and this annual event in particular, is most gratifying and worthy of recognition. SLAS is proud to call Hamilton a partner and to thank them for their support that enables the Society to deliver an event and exhibition of the quality and scope of SLAS2015." More

Time to Update SLAS Member Records
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As a registered user in the SLAS database, please take a moment to login and review your user profile to ensure it is accurate and up-to-date. Please pay special attention to your contact information, professional profile and SLAS communication preferences. Having an accurate profile ensures SLAS provides you with information on programs and services of most interest to you. Questions? Contact SLAS Manager of Member Services Mary Geismann at mgeismann@slas.org or by calling 877.990.SLAS (7527) or +1.630.256.SLAS (7527), extension 109. Thank you. More


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    Three SLAS Short Courses to be Presented in September in Basel, Switzerland
    SLAS     Share    Share on FacebookTwitterShare on LinkedinE-mail article
    SLAS, in collaboration with the Swiss Biotech Association, will present three short courses on Sept. 26 at the Pullman Hotel Basel.

    3D Cell-based Assays for Drug De-risking
    Presented by Markus Rimann of Zurich University of Applied Sciences; and Simon Messner of InSphero AG

    Label-Free/Biophysics Methods for Screening
    Presented by Christine Genick of Novartis Institutes for Biomedical Research; Jörg Weiske of Bayer; and Timothy Sharpe of University of Basel

    Applied Information Technology for the Laboratory
    Presented by Burkhard Schaefer of BSSN Software
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    Looking for Sept. 1 ELRIG courses? Click here.



    SLAS Career Connections: Boost Your Career or Find the Perfect Candidate
    SLAS     Share    Share on FacebookTwitterShare on LinkedinE-mail article
    SLAS Career Connections offers 24/7 online and SLAS2015 in-person career services. Recent posts on the job board include Director, Neurotransgenic Laboratory at Duke University; Research Scientist I at Broad Institute; Formulation Scientist at ProMetic BioTherapeutics; and Scientific Associate/Scientist ID Screening and Automation at Novartis Institutes for BioMedical Research. In addition to the job postings, take advantage of links to other helpful career resources. More

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    Novel Insights Gained on the Process of Cancer Metastasis
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Researchers at Brown University used a microengineered device that acts as an obstacle course for cells to shed new light on a cellular metamorphosis thought to play a role in tumor cell invasion throughout the body. The epithelial-mesenchymal transition (EMT) is a process in which epithelial cells, which tend to stick together within a tissue, change into mesenchymal cells, which can disperse and migrate individually. More

    Do Gut Bacteria Rule Our Minds?
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    It sounds like science fiction, but it seems that bacteria within us — which outnumber our own cells about 100-fold — may very well be affecting both our cravings and moods to get us to eat what they want, and often are driving us toward obesity. In an article published in the journal BioEssays, researchers concluded from a review of the recent scientific literature that microbes influence human eating behavior and dietary choices to favor consumption of the particular nutrients they grow best on. More

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    Tips for Establishing Successful Cell - Based Assays: Part 2
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    Standard Cell Culture Practices to Reduce Contamination Risk
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    Next-Gen Sequencing Is A Numbers Game
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Sequencing the human genome the first time cost $3 billion and took 13 years to complete. That was in 2003. Eleven years later, next-generation sequencing technology has brought the single-genome price close to $1,000 and cut the time to days. These advances have enabled new opportunities for genomic studies. For example, Genomics England, set up by the U.K.'s Department of Health, plans to sequence 100,000 human genomes by the end of 2017. More

    Selective Methyl Labeling of Eukaryotic Membrane Proteins Using Cell-Free Expression
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Structural characterization of membrane proteins and other large proteins with NMR relies increasingly on perdeuteration combined with incorporation of specifically protonated amino acid moieties, such as methyl groups of isoleucines, valines, or leucines. The resulting proton dilution reduces dipolar broadening producing sharper resonance lines, ameliorates spectral crowding, and enables measuring of crucial distances between and to methyl groups. More


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    Scientists Show How Ebola Disables Initial Immune Defenses
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Researchers report that they have discovered a mechanism unique to the Ebola virus that defeats attempts by interferon to block viral reproduction in infected cells. They say their study ("Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1"), published in Cell Host & Microbe, explains for the first time how the production by the virus of a protein called Ebola Viral Protein 24 (eVP24) stops the interferon-based signals from ramping up immune defenses. More

    The 12 Types of People You'll Meet at a Conference
    Hubspot    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    To all the conference-goers out there, I'd like to challenge you to think long and hard about one simple question: What's your goal? There are so many different benefits and things you could focus on during a conference; it gets really difficult to choose which one you should go for. Should you be networking to make connections with smart people? Should you stick to learning and diligently take notes during the breakout sessions? Maybe your goal is simply to follow the keynote speakers around until they notice you. More

    Hints of Epigenetic Role in Alzheimer's Disease
    New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Pioneering studies of post-mortem brain tissues have yielded the first evidence of a potential association between Alzheimer's disease and the epigenetic alteration of gene function. The researchers stress, however, that more research is needed to find out if the changes play a causal role in the disease or occur as a result of it. More



    New Thinking Needed for Superbug Treatments
    By Mike Wokasch    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Not a day goes by without reading or hearing about the seemingly impossible task of finding effective new treatments against "superbugs" that are resistant to existing drugs. The dearth of prospects for treating these superbugs is often blamed on the lack of investment and market economics. Sure, more investment-friendly healthcare market opportunities might lure additional pharma companies and money to the effort, but there is an even bigger factor standing in the way of conquering this medical dilemma. More

    Continuous-Flow Microelectroextraction for Enrichment of Low Abundant Compounds
    Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    We present a continuous-flow microelectroextraction flow cell that allows for electric field enhanced extraction of analytes from a large volume (1 mL) of continuously flowing donor phase into a micro volume of stagnant acceptor phase (13.4 μL). We demonstrate for the first time that the interface between the stagnant acceptor phase and fast-flowing donor phase can be stabilized by a phaseguide. More

    Rapid Analysis of Protein Farnesyltransferase Substrate Specificity Using Peptide Libraries and Isoprenoid Diphosphate Analogues
    ACS Chemical Biology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Protein farnesytransferase (PFTase) catalyzes the farnesylation of proteins with a carboxy-terminal tetrapeptide sequence denoted as a Ca1a2X box. To explore the specificity of this enzyme, an important therapeutic target, solid-phase peptide synthesis in concert with a peptide inversion strategy was used to prepare two libraries, each containing 380 peptides. More

    Chemists Uncover Powerful New Click Chemistry Reactivity
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Chemists led by Nobel laureate K. Barry Sharpless at The Scripps Research Institute have used his click chemistry to uncover unprecedented, powerful reactivity for making new drugs, diagnostics, plastics, smart materials and many other products. The new SuFEx — Sulfur Fluoride Exchange — reactions enable chemists to link molecules of their choice together using derivatives of a common commercial chemical considered essentially inert. More

    Researchers Developing Unique Molecular Probes for Study of Metals in Brain
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    You don't have to listen to heavy-metal music to be a metal head. The human brain harbors far more copper, iron and zinc than anywhere else in the body. Abnormally high levels of these metals can lead to disorders such as Alzheimer's and Parkinson's diseases. Chris Chang, a faculty chemist with Berkeley Lab's Chemical Sciences Division, has spent the past several years developing new probes and techniques for imaging the molecular activity of these metals in the brain. More


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    Career


    Research Scientist – Bioassay and Molecular Screening
    SRI International
    US – CA – Menlo Park

    Scientific Associate/Scientist, ID Screening and Automation
    Novartis Institutes for BioMedical Research
    US – CA – Emeryville

    Automation Scientist/Engineer
    BASF – The Chemical Company
    US – CA

    More jobs at SLAS Career Connections


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