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SLAS ELN Reports: Shaking Up 3D Culture — Novel Systems Agitate Cells to Facilitate Cell-Based Screening
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For life sciences discovery and technology professionals, working with 3D culture has numerous advantages, including emulation of the in vivo environment; high cell yields from less laboratory space; and a significant reduction in costs of labor and consumables. That's the word from Robin Felder, Ph.D., professor and associate director of clinical chemistry and toxicology at the University of Virginia School of Medicine.

Read more from Felder and Lee L. Rubin, Ph.D., Harvard Department of Stem Cell and Regenerative Biology, in the SLAS Electronic Laboratory Neighborhood e-zine feature article.
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JBS September Issue Now at JBS Online
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“The Use of Nucleosome Substrates Improves Binding of SAM Analogs to SETD8,” "Morphological Evaluation of Nonlabeled Cells to Detect Stimulation of Nerve Growth Factor Expression by Lyconadin B," "Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus" and "Flow Cytometric Method for the Detection of Flavonoids in Cell Lines" are among the original research articles in the September issue.

SLAS Biomolecular Sciences Section members and JBS subscribers can view the issue online now.
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SLAS2017 Registration Opens in Just a Few Weeks
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Online registration will be accepted for SLAS2017 in the very near future — watch SLAS2017.org for updates and to sign up to be notified when registration is live. SLAS2017 takes place Feb. 4-8, at the Walter E. Washington Convention Center in Washington, DC.

The most deeply discounted registration rates are available to those who register by Monday, Oct. 31. The Scientific Program Committee is reviewing scientific podium presentation abstracts – a record number were received this year — and expects to announce the program lineup in October. Poster abstracts are still being accepted.
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JBS Special Issue Call for Papers: Advances in MALDI Mass Spectrometry for Drug Discovery
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Guest editors Shannon Cornett, Ph.D., of Bruker and Michael Scholle, M.S., M.B.A. of SAMDI Tech invite your manuscript proposals (abstracts) by Sept. 30 for this 2017 special issue. Proposals will be used to select papers for submission and peer review.

Areas of interest include high-throughput MALDI applications; use of MALDI in enzyme characterization; applications of MALDI and MALDI imaging for metabolite detection and screening and for drug distribution studies; MALDI applications for characterizing small molecules; applications of MALDI imaging for early detection of toxicity; and MALDI applications for profiling cells, cell lines and biochemical samples and for determining metabolism and kinetics.
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Just for Fun: The SLAS Community is Coomassie Blue!
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Intelligence, communication, trust, efficiency, serenity, duty, logic, coolness, reflection, calm — these words describe the 46% who tested coomassie blue in the recent SLAS2017 fun quiz — Which Reagent Are You?

"You are all about trust, honor and loyalty. You are sincere, reserved and quiet. You don't like to make a fuss or draw attention to yourself. You hate confrontation and like to do things your own way. You have a need for order and direction in your life, particularly in your living and work spaces. As a blue, you are reliable and responsible. You exhibit inner security and quiet confidence, and you seek peace and tranquility above all else, promoting both physical and mental relaxation. In others, you help to reduce stress and anxiety and produce a sense of calmness, relaxation and order."

The closest contender at 25% was methyl orange which represented physical comfort, food, warmth, security, sensuality, passion, abundance, fun.
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Use Kudos to Explain, Enrich and Share Your Published Papers
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Journal authors using Kudos in 2013 enjoyed 19% higher downloads of their published work than non-users. Kudos is a web-based service that helps researchers and their institutions and funders to maximize the visibility and impact of their published articles. The service provides a platform for assembling and creating information to help search filtering, for sharing information to drive discovery and for measuring and monitoring the effect of these activities.

Basic service is free to SLAS journal authors. The SLAS publishing team will provide more information and answer questions about Kudos at the SLAS Scientific Journals Information Station at SLAS2017.
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A New Way to Display the 3-D Structure of Molecules
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Researchers at the Department of Energy's Lawrence Berkeley National Laboratory and UC Berkeley have created a sort of nanoscale display case that enables new atomic-scale views of hard-to-study chemical and biological samples. Their work could help to reveal new structural details for a range of challenging molecules — including complex chemical compounds and potentially new drugs — by stabilizing them inside sturdy structures known as metal-organic frameworks. More


Distract DNA Repair to Cinch CRISPR Knockout
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Just because a gene is cut and disabled doesn't mean the cell's DNA repair mechanisms are ready to throw in the towel. No, they stay in the gene's corner, patching the gene's damage, keeping the gene in the transcriptional ring. Because the gene's molecular seconds can lessen knockout efficiency, those who would keep the gene down for the count might consider a two-step strategy. First, as always, groom the most formidable opponent, the most efficient CRISPR/Cas9–single-guide RNA combination. More




Membrane Separates Hydrocarbon Isomers in Energy-Saving Process
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A membrane that separates organic solvent molecules based on their shape and size could dramatically cut costs associated with preparing valuable polymer feedstocks, such as p-xylene. It works as part of a reverse-osmosis process, a common method for water desalination that hasn't been applied to organic solvents until now. More


Iterative Evolution of an Abiotic Foldamer Sequence for the Recognition of Guest Molecules with Atomic Precision
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A synthetic helical aromatic oligoamide foldamer receptor with high affinity and selectivity for tartaric acid was subjected to a structure-based evolution of its sequence via mutations, additions, and deletions of monomers to produce a new receptor having high affinity and selectivity for malic acid, a guest that differs from tartaric acid by a single oxygen atom. Seven iteratively modified sequences were synthesized. More


Engineers Program Human Cells to Store Complex Histories in Their DNA
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MIT biological engineers have devised a way to record complex histories in the DNA of human cells, allowing them to retrieve "memories" of past events, such as inflammation, by sequencing the DNA. This analog memory storage system — the first that can record the duration and/or intensity of events in human cells — could also help scientists study how cells differentiate into various tissues during embryonic development, how cells experience environmental conditions, and how they undergo genetic changes that lead to disease. More


Researchers Watch Catalysts at Work
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Physicists at the University of Basel have succeeded in watching a silver catalyst at work for the first time with the aid of an atomic force microscope. The observations made during an Ullmann reaction have allowed the researchers to calculate the energy turnover and, potentially, to optimize the catalysis. The study, which was performed with experts from Japan and Iran, has been published in the scientific journal Small. More


Toward a Nonaddictive Opioid
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Opioids relieve chronic pain for millions, but are highly addictive and can cause potentially fatal side effects. In a paper published Aug. 17 in Nature, scientists identify a compound that could offer pain relief without risk of addiction. It's the latest promising drug development in an effort to curb a growing opioid epidemic in the United States. More


A Newly Made RNA Strand Bolsters Ideas About How Life on Earth Began
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A fundamental property of life is the ability to replicate itself. Researchers have now created the first molecules of RNA, DNA's singled-stranded relative, that are capable of copying almost any other RNAs. The discovery bolsters the widely held view among researchers who study the origin of life that RNA likely preceded DNA as the central genetic storehouse of information in the earliest cells some 4 billion years ago. Ironically, the new RNA copiers still can't duplicate themselves. More


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Automation Engineer, Next Generation Sequencing
Roche Diagnostics
US – MA – Boston

High-Throughput Biologics Formulation and Analysis Research Scientist
Eli Lilly and Company
US – IN – Indianapolis

Bio-Analytical Product Development Manager
Tomtec Inc.
US – CT – Hamden

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