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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit August 26, 2015

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JBS Special Issue on Screening by RNAi and Precise Genome Editing Technologies
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Organized by three distinguished members of the JBS Editorial Board – Marc Bickle, Hakim Djaballah and Lorenz Martin Mayr – this special issue’s 11 scientific manuscripts illustrate how RNAi is enjoying a revival of popularity and is increasingly being applied to discover and validate targets being investigated for therapeutic use. “We now have tools that allow us to use RNAi strategies in primary cells, minimize off-target effects and rapidly obtain high quality screening data,” says Bickle.

Djaballah adds, “the technology is on the rebound, but in a more conservative way than in previous years. Researchers are careful about the assays they’re developing and about interpreting the data their work yields. We know RNAi is helpful when we go after genes of interest. While it hasn’t been as useful yet for finding the needle in the haystack (identifying a gene based on a specific effect), the new tools will help.” SLAS Biomolecular Sciences Section members and JBS subscribers can view the issue online now.
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ANSI Approves SLAS Microplate Standards Advisory Committee
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The American National Standards Institute (ANSI) audited and approved policies and procedures for the new SLAS Microplate Standards Advisory Committee. SLAS requested these changes to reflect its move from developing new microplate standards to maintaining the five key industry standards for footprint dimensions, height dimensions, bottom outside flange dimensions, well positions and well bottom elevation. The committee retains its ability to oversee the creation of any new standards, should the directive arise.

SLAS plans to issue a call for participation in November to serve on this new committee, which will be charged to prepare for reaccreditation of the five standards in 2017. As directed by ANSI, the committee will comprise balanced representation by manufacturers of microplates, manufacturers of instruments that utilize microplates, industrial and academic users of microplates and those with a general interest but do not fit in the previous categories.
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Free at JBS: Neuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and Pitfalls
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Edward S. A. Humphries and Caroline Dart, Institute of Integrative Biology at the University of Liverpool (UK), share what a range of human genetic disorders say about the role of specific K+ channel subunits; explore the potential of activators and inhibitors of specific channel populations as a therapeutic strategy; and discuss possible reasons for the difficulty in designing clinically relevant K+ channel modulators.

This important review article will be featured on the front cover of the October issue of the Journal for Biomolecular Screening. In the meantime, it is available ahead-of-print for free at JBS Online.
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SLAS Has 18,000-Plus Friends, Fans & Followers: Are You One of Them?
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SLAS President Dean Ho addresses the growth of social media and its impact on SLAS members in his latest From the SLAS President column in the SLAS e-zine. "Social media networking is no longer a novelty. It's an essential component of business and personal life. I rely on SLAS postings and tweets to keep me informed of what's going on in real-time."

If you are not yet involved with SLAS on Twitter, Facebook, LinkedIn or YouTube, Ho encourages you to do so. "SLAS social media demonstrates the here-and-now ability of our scientific community to join forces, exchange information and ideas, and maximize opportunities. People are talking. Join the conversation!"
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SLAS Seeks Nominations for The 2016 JALA TEN
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Every year, JALA honors the top 10 technological breakthroughs that made seminal impact toward addressing key biological and medical quandaries. The JALA Ten embraces a spectrum of fields that include but are not limited to laboratory automation, robotics, drug discovery, drug screening, novel therapeutic strategies and delivery technologies, diagnostics, nanotechnology, nanomedicine, microtechnology as it relates to biology and medicine, novel characterization techniques and more.

Nominations are due Oct. 1 and are open to SLAS members and nonmembers, and self-nominations are welcome.
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Share the SLAS Story
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Do you have colleagues who could profit from the benefits and advantages of SLAS membership?

Tell them why you belong and share this link so they can learn first-hand how others have advanced their careers and enhanced their personal lives through SLAS membership.
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Researchers Describe How DNA Proofreader Proteins MutS and MutL Work
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists from North Carolina State University and the University of North Carolina at Chapel Hill say they have discovered how two important proofreader proteins know where to look for errors during DNA replication and how they work together to signal the body's repair mechanism. During DNA replication, the nucleotides are a correct match most of the time, but occasionally, about one time in a million, there is a mismatch. More


Scientists Explore Origins of Energy in Chemical Reactions Using Experimental Quantum Chemistry
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One thing that all chemical reactions have in common — whether they are the reactions that take place inside a battery, the metabolic reactions inside a living organism, or the combustion reactions that cause an explosion — is that they all involve some kind of change in energy. On a large scale, the changes in energy of a reaction can usually be measured in various ways for practical purposes, but attempting to understand the fundamental origins of this energy at smaller and smaller scales becomes more complicated, especially as chemistry enters the quantum realm. More




A pH-Sensitive Polymer Could Lead To Long-Term Drug Delivery Devices
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A new family of polymers could help fight obesity and antibiotic resistance just by falling apart. Researchers led by Giovanni Traverso of the Massachusetts General Hospital and Robert Langer of Massachusetts Institute of Technology have synthesized hydrogels that are stable in stomach acid, but dissolve in the neutral pH of the intestines. These materials will enable researchers to develop safer gastric resident devices, which live in patients' stomachs for extended periods of time, said Shiyi Zhang. More


X-ray Laser Experiment Could Help in Designing Drugs for Brain Disorders
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Scientists have revealed never-before-seen details of how the human brain sends rapid-fire messages between its cells. Researchers at the School of Medicine and the Department of Energy's SLAC National Accelerator Laboratory mapped the 3-D atomic structure of a two-part protein complex that controls the release of signaling chemicals, called neurotransmitters, from brain cells. More


Rethinking Lymphatic Development
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For 10 years, Karina Yaniv has worked to find out just how much zebrafish have in common with mice — at least when it comes to their lymphatic systems, the open-ended networks of vessels best known for draining fluids from tissues and providing thoroughfares for immune cells throughout the body. Yet in doing so she ended up discovering something that had very little in common with the findings of numerous earlier studies on other animals' lymphatic systems. More


Company R&D Expenditures in U.S. Rose in 2013
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Companies spent $323 billion on research and development performed in the United States during 2013, 6.7 percent more than the $302 billion they spent the previous year. A new report from the National Science Foundation's National Center for Science and Engineering Statistics finds that the companies' own level of R&D funding also rose, going from $247 billion to $265 billion between 2012 and 2013. More


How Does the New 'Female Viagra' Work?
Science Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The libido enhancement drug flibanserin (trade name Addyi) took center stage after winning long-sought approval from the U.S. Food and Drug Administration. The coverage from advocates and nonbelievers has run the gamut — advice, caution, and criticism likely to confuse undecided, but curious, onlookers. But exactly how Addyi drums up sex drive is still murky. More


What Do Rocks Have in Common With Liver Cancer?
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A group of clinicians and geochemists are working to develop a test for the most common form of primary liver cancer, HCC (Hepatocellular Carcinoma). HCC kills over 600,000 people worldwide every year. It usually develops from chronic liver disease such as hepatitis or cirrhosis, but there is no good biochemical test to indicate when the cancer develops, meaning that even for patients most at risk, it is nearly impossible to know when a cancer may develop until symptoms appear. More


Career


NGS Automation Engineer
Kapa Biosystems
US – MA – Boston

Application Scientist (Automation Engineer)
New York Genome Center
US – NY – NY

Senior Automation Engineering Manager
Counsyl
US – CA – South San Francisco

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