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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit August 30, 2017

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SLAS Discovery: New Therapeutic Targets for Osteoarthritis Pain
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A new review by David A. Walsh and Joanne Stocks in the September 2017 issue of SLAS Discovery explores evolving treatments and future therapies for osteoarthritis (OA) pain. It covers the limitations of existing treatments and introduces the latest understanding of the complex mechanisms behind OA pain, which offers exciting new possibilities and potential new treatment targets.

Full access is available to nonmembers for a limited time. Full access always is available to subscribing SLAS Premier members and all Premier Plus members.
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From the SLAS President: Good News About the ANSI/SLAS Microplate Standards
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"Our complement of five ANSI/SLAS Microplate Standards have been reaffirmed by the SLAS Microplate Standards Advisory Committee in compliance with the process and requirements of the American National Standards Institute (ANSI), the U.S. standards and conformity assessment system that oversees the creation, promulgation and use of thousands of norms and guidelines that directly impact businesses in nearly every sector," says SLAS President Scott Atkin. "These standards are an outstanding example of how our Society serves as an important and officially recognized voice of authority in life sciences discovery and technology."

Read more in the SLAS Electronic Laboratory Neighborhood e-zine.
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SLAS Membership: What Can It Mean for You?
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SLAS membership puts you at the center of the life sciences discovery and life sciences technology community where accomplished researchers, scientists, engineers, innovators and entrepreneurs come together to continually improve and reinvent our world.

SLAS premier members in particular are granted immediate access to a universe of valuable member benefits that positions them on a trajectory to professional success. Not yet a premier (dues-paying) member with access to all benefits? Center yourself, and join or upgrade today!
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SLAS Author Workshop at ELRIG, Oct. 3-4
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It can be frustrating for many prospective authors when a scientific paper submitted to a journal is returned with a list of questions and revision requests. The SLAS Author Workshop at ELRIG Drug Discovery 2017 explains why constructive criticism should be considered a gift. Papers are rarely accepted as written, and editors do not forward papers into review unless they believe they are good candidates for publication. Authors who are patient and open-minded can benefit greatly from the objective counsel provided by the experts who contribute to the confidential review process.

Join SLAS Discovery Editorial Board member and guest editor Rob Howes, Ph.D. (AstraZeneca) at ELRIG in Liverpool, UK. Learn more about the SLAS journals (SLAS Discovery and SLAS Technology).
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What's Your SLAS2018 'Where Discovery Meets Technology' Online Handle?
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The Internet is replete with online handles like "chem-space" or "PharmaJohn." If you had to create an online handle inspired by the SLAS2018 "Where Discovery Meets Technology" theme, what would yours be?

To find out, use the convenient SLAS handle generator to determine your personal discovery-technology moniker! Then be sure to submit a poster abstract to present at SLAS2018, Feb. 3-7, San Diego, and share your new handle on social media.

Students: be sure to apply for an SLAS Tony B. Academic Travel Award when you submit your poster abstract.
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Metal Simplifies Synthesis of Antibody Drugs
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Rice University scientists have developed a method to efficiently modify natural antibodies that can deliver drugs to target cells. Adding a little extra metal is the key. Rice chemist Zachary Ball and graduate student and lead author Jun Ohata discovered that rhodium, a rare transition metal, can be a useful element in the design and preparation of antibody drug conjugates (treatments) that have become a standard tool for targeted delivery of drugs such as chemotherapeutics. More


Antibiotic Resistance Rises in 'Lonely' Mutating Microbes
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A major study led by the University of Manchester has discovered that so called "lonely" microbes, those living at low population densities, are more likely to mutate causing higher rates of antibiotic resistance. After analyzing 70 years of data and nearly 500 different measurements of mutations, the study shows individual microbes — such as bacteria — found in denser microbial populations mutate much less than microbes in sparser groups. More




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Terpene Cyclizations Inside a Supramolecular Catalyst: Leaving-Group-Controlled Product Selectivity and Mechanistic Studies
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The tail-to-head terpene cyclization is arguably one of the most complex reactions found in nature. The hydrogen-bond-based resorcinarene capsule represents the first man-made enzyme-like catalyst that is capable of catalyzing this reaction. Based on noncovalent interactions between the capsule and the substrate, the product selectivity can be tuned by using different leaving groups. More


Triplet Diradical Cyclobutadiene Spotted for the First Time
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Carbon and silicon are both group 14 elements. That's supposed to mean that the two elements share many chemical properties. They do, yet the properties of their low-coordinate compounds are dramatically different: For example, although C=C bonds are ubiquitous, Si=C and Si=Si bonds are rare, and the latter can be isolated only when sterically protected by large substituents. More


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When 2 Immunotherapy Rights Make a Wrong
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Recent advances in immunotherapy have given many cancer patients stricken with tumors intractable to current therapies hope for meaningful remission times. While researchers continue to try and understand the intricacies of the immune system's response to carcinogenesis, many clinicians are looking for combinations of immunotherapy compounds to provide an even greater response to cancer suppression. More


Technology Key to Fighting Neurological Disease
R&D Magazine via Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
New technologies may be on the way to better help doctors diagnose and treat patients with neurological diseases. Researchers from the National Neuroscience Institute and Nanyang Technological University, Singapore have come together to develop several new technologies, including an artificial intelligence system that can accurately identify types of traumatic brain injuries from computed tomography scans. More




More Inflexible Than Imagined
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Oligosaccharides — chains of sugar building blocks — are essential for biological cells. Scientists had thought that these molecules were freely mobile, but an international research team has now shown that such sugar molecules can form rigid structures, previously found only in DNA and proteins. Oligosaccharides — chains of sugar building blocks — are some of the most important molecules in living creatures. More


Career


Director, Automation and Screening
Sangamo Therapeutics
US – CA – Richmond

Automation Scientist
Recursion Pharmaceuticals
US – UT – Salt Lake City

Lab Automation Engineer 1
Calico
US – CA – South San Francisco

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