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Sept. 2, 2020

SLAS NEWS

This Week’s New Matter Episode: Lots of Wheels and Motors This week’s New Matter: Inside the Minds of SLAS Scientists podcast episode features Kevin Chang, Chair of the BadgerBOTS Team 1306, whose team won the Wisconsin Regional 2020 FIRST Robotics Chairman's award. Listen as he, finance whiz Max Roquitte and CAD engineer Cal Rossman explain the inner workings of their winning robot, how FIRST helps kids get into STEM fields and how SLAS can help get automation motivation up! LISTEN NOW

Be Proactive and Positive SLAS SLAS President Emilio Diez Monedero shares a special message in this month’s From the SLAS President column in Electronic Laboratory Neighborhood. Diez Monedero addresses the all-too-real “pandemic overload” and suggests that those feeling the extra burden should “focus on being proactive in helping reach solutions and to look to the many positives,” such as the numerous contributions the SLAS community has made towards vaccines, therapeutics and other COVID-19 solutions. He also highlights how the Society has pivoted to provide forward-thinking ways to deliver robust educational programs to the SLAS community, including the shift of SLAS2021 from an in-person to fully virtual event. READ MORE

September's Webinar Series on Cancer Research and Drug Discovery Starts Next Week SLAS Registration is open for the three-part webinar series focusing on important cancer drug discovery topics such as the use of 3D cellular models in pre-clinical testing and drug screening, and how patient-derived scaffolds can be used to simulate microenvironments. Block off time on your calendar for: Thursday, September 10, 7:00 a.m.: Redefining Pre-Clinical Testing in Oncology: Why We Need to Go 3D Tuesday, September 15, 7:00 a.m.: The Roadmap for the Next Generation Oncology: The Contribution of Tridimensional Models Tuesday, September 22, 7:00 a.m.: Patient Derived Scaffolds (PDS) in Cancer Research and Drug Discovery All times are CDT and each webinar is one hour. Registration is FREE for SLAS members and $20 each for all others. REGISTER NOW

New Live Webinar Date Announced: Compound-Mediated Interferences in Homogeneous Proximity Assays SLAS The Jayme L. Dahlin, M.D., Ph.D., (Brigham and Women’s Hospital) live presentation “Compound-Mediated Interferences in Homogeneous Proximity Assays” has been rescheduled for Friday, September 25 at 11:00 a.m. CDT. Dahlin’s webinar will cover the basic principles of: homogeneous proximity assays, common sources of compound-mediated interference in homogeneous proximity assay and counter-screens and other strategies to mitigate and identify compound-mediated assay interferences in homogeneous proximity assays. Registration is now open and is FREE for SLAS Premier Members and $20 for all others. LEARN MORE

SPONSORED VIDEO The Ultimate Laboratory Microplate Mover The Thermo Scientific™ Orbitor™ RS2 microplate mover is a collaborative bench-top mover that provides unbeatable reliability and improved process efficiency. It’s innovative bi-directional telescoping arm coupled with it’s expansive 360° workspace provide exceptional reach and precision, making the Orbitor RS2 your trusted laboratory productivity partner. WATCH VIDEO

Upcoming SLAS2021 Digital Presentation Deadline Reminders SLAS Two important live talk abstract submission deadlines are less than two weeks away. Regular and Tony B. Academic Award live talk abstracts are due Monday, September 14. All members of the SLAS community are encouraged to submit an abstract while students, graduate students, post-doctoral associates and junior faculty (less than four years in first academic appointment) are encouraged to apply for the Tony B. Academic Award program. Additional important deadlines are listed below: Tony B. Academic Award poster submission deadline: Monday, October 5 Student Poster Competition abstract submission deadline: Monday, October 19 Poster abstract submission deadline: Monday, January 11 Don’t miss out on the variety of opportunities to present your original research via a live discussion or poster at SLAS2021 Digital! VIEW COMPLETE CALL FOR ABSTRACTS DETAILS

Ignite the Visibility of Your Start-up with a Spot 'on' Innovation AveNEW SLAS Start-ups and emerging life sciences companies: do not pass up this opportunity to gain additional promotion for your product or service! Innovation AveNEW exhibitors can amplify their company’s brand via this specially designated area of the SLAS2021 Digital platform allowing for quick connections to purchasing influencers and decision-makers from around the world — at no cost. Innovation AveNEW companies pay no exhibition fees and are rewarded with access to a global audience, business consulting and are invited to compete for the SLAS Ignite Award, which recognizes the best start-up or emerging company with a $5000 award and multi-channel publicity before, during and after the event. LEARN MORE

PRODUCT SHOWCASE Accelerate biologics development Introducing the BioXp™ 3250 system, a fully automated synthetic biology workstation. It dramatically reduces the timelines for identifying antibody and vaccine candidates from weeks to days by assembling DNA clones, libraries, and gene fragments — as long as 7,000 base pairs — in a single overnight run. LEARN MORE

SLAS Discovery and SLAS Technology Publishing Opportunities SLAS Two SLAS journal submission deadlines remain in 2020, and both are just around the corner. Being published in SLAS Discovery or SLAS Technology offers an invaluable opportunity for research to gain additional visibility within the global life sciences and technology community and increases the chance for it to be cited within other publications and research papers. Emerging Trends in 3D Cell Culture SLAS Technology Suggested topics include: high-throughput screening, disease modeling and translational medicine. Submission Deadline: September 15, 2020 High-Content Imaging and Informatics: Annual Joint Special Issue with SBI2 SLAS Discovery Suggested topics include: review of the colloquium report on AI in HCS/HCA, application/technical notes based on poster presentation research, methods/descriptions supporting AIML analysis of images, perspectives on future imaging technologies and integrated uses of AIML in discovery and commentary on imaging. Submission Deadline: October 20, 2020

New COVID-19 Articles Available in SLAS Discovery SLAS Four new original research papers are available via Open Access ahead of the publication’s December special issue, “Approaches to Identifying Anti-Viral Compounds/Therapies Focusing on COVID-19/SARS-CoV-2.” Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19 RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates Potential Repurposed Therapeutics and New Vaccines against COVID-19 and Their Clinical Status

SPONSORED CONTENT Promoted by Corning • E-book Download: All About Organoids • Video: Using Organoids for Personalized Medicine: An Interview with Sylvia Boj from HUB • Harnessing Next-Generation Cell Culture Methods in the Fight Against Cancer • Modeling Kidney Disease with Bioengineered Kidney Organoids • Webinar Series: Organoid Masterclasses

Calendar of Important Dates SLAS SLAS2021 Digital International Conference and Exhibition — Call for Abstracts Now Open January 25 – 27, 2021 View live talk and poster abstract submission details September Webinar Series Redefining Pre-Clinical Testing in Oncology: Why We Need to Go 3D September 10 7:00 a.m. CDT The Roadmap for the Next Generation Oncology: The Contribution of Tridimensional Models September 15 7:00 a.m. CDT Patient Derived Scaffolds (PDS) in Cancer Research and Drug Discovery September 22 7:00 a.m. CDT Rescheduled from August: Compound-Mediated Interferences in Homogeneous Proximity Assays September 25 11:00 a.m. CDT

FEATURED ARTICLE Drug screening in patient tumor micro environment Promoted by Iscaffpharma Sortina Pharma use Iscaffpharma’s patient derived scaffolds to create drug fingerprints and select drugs for aggressive cancer. Read Case READ MORE

HEADLINES

Tracking Charge Transfer to Residual Metal Clusters in Conjugated Polymers for Photocatalytic Hydrogen Evolution Journal of the American Chemical Society Semiconducting polymers are versatile materials for solar energy conversion and have gained popularity as photocatalysts for sunlight-driven hydrogen production. Organic polymers often contain residual metal impurities such as palladium clusters that are formed during the polymerization reaction, and there is increasing evidence for a catalytic role of such metal clusters in polymer photocatalysts. READ MORE

Real-Time Photoluminescent Biosensing Based on Graphene Oxide-Coated Microplates: A Rapid Pathogen Detection Platform Analytical Chemistry Pathogenic bacterial contamination is a major threat to safety, human health, and ecosystems. Herein, we report an advantageous single-step, wash-free, and real-time bacterial detection platform operating with a single antibody. Escherichia coli was detected as a model analyte. This technology is based on graphene oxide-coated microplates and photoluminescent bioprobes. READ MORE

PRODUCT SHOWCASE

Convenient. Consistent. Certain. Matrigel matrix-3D plates are a pre-coated, convenient, off the shelf option that improve productivity and consistency in homogenous assays where 3D structures are grown and assayed directly in the plate. Using a pre-coated option eliminates the need to handle small volume ECM dispensation and helps reduce workflow steps LEARN MORE Biospecimen Acquisition to Support Research The Cooperative Human Tissue Network (CHTN) is a unique NCI supported resource that provides human tissues and fluids prospectively from surgeries, autopsies and other routine procedures to investigators who utilize human biospecimens in their research. Visit our website for more information and pricing or contact our Central Coordinator. LEARN MORE

In 'Milestone,' FDA OKs Simple, Accurate Coronavirus Test That Could Cost Just $5 Science Magazine Coronavirus testing is set to get faster. The U.S. Food and Drug Administration gave an emergency use authorization to Abbott Laboratories for a 15-minute test that should ease bottlenecks. Analogous to tests that detect HIV and influenza, the new diagnostic detects viral proteins, or antigens, that are unique to SARS-CoV-2, the virus that causes COVID-19. Unlike conventional coronavirus diagnostics, Abbott’s test requires no specialized laboratory equipment. READ MORE

Is a Bradykinin Storm Brewing in COVID-19? The Scientist On a Sunday afternoon in mid-April this year, Daniel Jacobson, a computational systems biologist at Oak Ridge National Laboratory in Tennessee, was looking at gene expression data from the lung fluid of COVID-19 patients on his computer screen when he spotted something striking — the expression of genes for key enzymes in the renin-angiotensin system, involved in blood pressure regulation and fluid balance, was askew. READ MORE

PRODUCT SHOWCASE The High Performance Microplate Solution.­ Aurora is 100% focused on making the highest quality, highest performing Microplates available. We use the best materials, the cleanest and most precise molding operations for our Microplates. We believe that the best Microplates should be an invisible carrier for your work - not a contributor to variability in your data. LEARN MORE

Moderna COVID-19 Vaccine Shows Immunogenicity in Older Patients Genetic Engineering & Biotechnology News Moderna presented Phase I data showing that its closely-watched messenger RNA COVID-19 vaccine candidate mRNA-1273 showed immunogenicity in patients 55 years old and older that was roughly the same or higher than data seen in younger patients at the dosage the company is using in its Phase III trial. Moderna’s series of two 100 mcg doses of mRNA-1273 seroconverted all 120 participants in a Phase I trial after the first dose given on Day 1. READ MORE

A Leap Forward for Biomaterials Design Using AI Science Daily Researchers have used artificial intelligence to predict the degree of water repulsion and protein adsorption by ultra-thin organic materials. By enabling accurate predictions of water repulsion and protein adsorption even by hypothetical materials, the team's approach opens up new possibilities for the screening and design of organic materials with desired functions. READ MORE

Measure cAMP Signaling in Live Cells Use cADDis to measure cAMP through Gs or Gi signaling in real time. Easily detectable on plate readers & imaging systems Bright green or red fluorescent readout High signal-to-noise ratio MORE INFO

Nanomaterials— Short Polymers, Big Impact Phys.org Oak Ridge National Laboratory scientists have discovered a cost-effective way to significantly improve the mechanical performance of common polymer nanocomposite materials. The discovery could lead to stronger, more durable materials for applications ranging from biomedical devices to automobile tires. Glassy polymer nanocomposites, or PNCs, are sought-after materials with hard filler nanoparticles dispersed throughout their soft polymer matrices. READ MORE

Lab Gains New Insight Into Key Membrane Proteins Lab Manager Portland State University researchers used advanced electron microscopy to create a 3-D reconstruction of a membrane protein at an unprecedented level of resolution, setting the stage for the development of drugs that could target the protein more effectively to treat a variety of diseases. The Reichow Lab uses cryo-electron microscopy and computer modeling to visualize how individual proteins in cells interact and function at the molecular level. READ MORE

CAREER CONNECTIONS

Job Seekers: Post your résumé and sign up for new job alerts by keyword. Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings. Scientific Director SLAS US – IL – Oak Brook Research Technician - Clinical Sciences Tufts University US – MA – Grafton Research Assistant 2 Oregon Health and Science University US – OR – Portland Search Jobs at SLAS Career Connections

THANK YOU 2020 SLAS CORPORATE MEMBERS

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