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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit September 6, 2017

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Register Today for the SLAS Europe High-Content Screening Conference, Sept. 19-20, Madrid
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The SLAS Europe High-Content Screening Conference brings together scientists, technologists, researchers, academics and data informatics professionals from many countries to share their experience and latest results in high-throughput microscopy and data analysis. The scientific chairs indicate there is currently a revolution in biology with the emergence of several ground-breaking technologies, ranging from stem cell culture, organoids, genome engineering to engineering progresses such as microfluidics, bioprinting, imaging modalities and sequencing methods.

"These extraordinary advances in the various fields are being integrated into research projects with astounding results, and this conference will offer some examples of how scientists are integrating these advances into their research to produce novel insights into biology." On Thursday, Sept. 21, the annual Spanish Drug Discovery Network meeting is being held at the same venue.
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September Issue Now at SLAS Discovery Online for Members and Subscribers
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"Image-Based Phenotypic Screening with Human Primary T Cells Using One-Dimensional Imaging Cytometry with Self-Tuning Statistical-Gating Algorithms," "Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score," "Development of a Modular Automated System for Maintenance and Differentiation of Adherent Human Pluripotent Stem Cells" and "A Screening Approach for Identifying Gliadin Neutralizing Antibodies on Epithelial Intestinal Caco-2 Cells" are among the original research articles in the issue.

The September issue also includes a review, "New Therapeutic Targets for Osteoarthritis Pain," with full access available to nonmembers for a limited time and "High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease," a SAGE Choice article with open access.
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SLAS2018 Poster Abstracts Due Sept. 25 for Tony B. Academic Travel Award Consideration
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The Tony B. Academic Award is one way SLAS ensures that up-and-coming researchers who demonstrate outstanding achievement can learn from and interact with life sciences discovery and technology community leaders. If selected for a Tony B. Award at SLAS2018 (Feb. 3-7 in San Diego, CA), travel, hotel accommodations and conference registration are provided to the primary author of a submitted podium or poster abstract.

Since SLAS was founded in 2010, SLAS Tony B. Academic Travel Awards have provided funding to enable 337 students, post-docs and early career professionals from around the world to participate in SLAS International Conferences and Exhibitions. Abstracts and applications for SLAS2018 are due Sept. 25 for poster presentations; the podium deadline has passed.
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Free SLAS Webinar on 3D Assays: Sept. 26
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Brad Larson of BioTek Instruments and Mark Rothenberg of Corning Life Sciences share their expertise on the cellular microenvironment and its importance when developing and screening cell-based assays using primary, stem cell and immortalized cultures in 3D systems. "3-Dimensional Assays: What Must Be Done for Setting Up and Validating for Downstream Microplate Reader and Imaging Applications" will be presented live Sept. 26 and then available on demand. This SLAS Webinar is open to members and non-members alike.

Read more about the topic in the SLAS Discovery Special Issue on 3D Cell Culture, Drug Screening and Optimization (featuring free access to select articles courtesy of Corning) and the SLAS Electronic Laboratory Neighborhood feature article. Register today!
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SLAS FUNd Run Set for SLAS2018
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This popular non-competitive event returns to SLAS2018 Tuesday, Feb. 6, along the beautiful San Diego waterfront. The measured route for this run/walk is 3.1 miles or 5K, flat and paved concrete throughout.

Run for free, or contribute $25 to receive an exclusive SLAS2018 FUNd Run shirt. Register for the run when you register for the conference later this month. The FUNd Run is sponsored by Tecan.
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ACS Reviewer Lab: Free Training Benefits Authors and Reviewers
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A new (and free) interactive online training program from the American Chemical Society (ACS) prepares volunteers interested in serving as manuscript reviewers and provides authors with excellent insight into how papers are critically assessed when being considered for publication in peer-reviewed journals.

The program requires 3-4 hours to complete and users must score at least 90% to graduate.
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CRISPR Genome Scan Reveals Key Immune System Regulators
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
While much of the excitement around CRISPR gene editing focuses on its medical and public health applications, the ability to precisely edit virtually any DNA sequence is a revelation for basic research. In the latest demonstration, researchers at the University of California and elsewhere have used a modified version of CRISPR gene editing to identify genetic regulatory elements (enhancers) involved in autoimmune diseases. More


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Mayo Clinic Researchers Identify Genes Fueling Neuroblastoma Spread
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For the first time, Mayo Clinic researchers and colleagues present data on how nervous system tumors, called neuroblastomas, spread. Their paper, published in Cancer Cell, clarifies the relationship between two genes that fuel the aggressive spread of neuroblastomas. Neuroblastoma is a cancer that most commonly affects children age 5 or younger, though it may rarely occur in older children. More


Researchers Set New Bar for Water-Splitting, CO2-Splitting Techniques
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Researchers from North Carolina State University have significantly boosted the efficiency of two techniques, for splitting water to create hydrogen gas and splitting carbon dioxide (CO2) to create carbon monoxide (CO). The products are valuable feedstock for clean energy and chemical manufacturing applications. The water-splitting process successfully converts 90 percent of water into hydrogen gas, while the CO2-splitting process converts more than 98 percent of the CO2 into CO. More




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Observation of Photovoltaic Action from Photoacid-Modified Nafion Due to Light-Driven Ion Transport
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Replacing passive ion-exchange membranes, like Nafion, with membranes that use light to drive ion transport would allow membranes in photoelectrochemical technologies to serve in an active role. Toward this, we modified perfluorosulfonic acid ionomer membranes with organic pyrenol-based photoacid dyes to sensitize the membranes to visible light and initiate proton transport. More


DRILL: An Electrospray Ionization-Mass Spectrometry Interface for Improved Sensitivity via Inertial Droplet Sorting and Electrohydrodynamic Focusing in a Swirling Flow
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
We describe the DRILL (dry ion localization and locomotion) device, which is an interface for electrospray ionization (ESI)-mass spectrometry (MS) that exploits a swirling flow to enable the use of inertial separation to prescribe different fates for electrosprayed droplets based on their size. This source adds a new approach to charged droplet trajectory manipulation which, when combined with hydrodynamic drag forces and electric field forces, provides a rich range of possible DRILL operational modes. More


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Chemist Synthesizes Pure Graphene
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Formed deep within Earth, stronger than steel, and thinner than a human hair. These comparisons aren't describing a new super hero. They're describing graphene, a substance that some experts have called "the most amazing and versatile" known to humankind. UConn chemistry professor Doug Adamson, a member of the Polymer Program in UConn's Institute of Materials Science, has patented a one-of-a-kind process for exfoliating this wonder material in its pure (unoxidized) form. More


Synthetic Simplification of Hallucinogen Pays Off
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Salvinorin A, a hallucinogen produced by the Mexican plant Salvia divinorum, holds promise for treating itch and pain because it activates the κ-opioid receptor while avoiding the μ-opioid receptor, a sister receptor that’s been associated with opioid abuse. Chemists have tried to synthesize salvinorin A so that they could alter the structure to sidestep the compound’s psychoactive effects while preserving its analgesic properties. But salvinorin A's scaffold has been challenging to recreate. More




New Fluorescent Dyes Could Advance Biological Imaging
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
With a new technique to craft a spectrum of glowing dyes, chemists are no longer chasing rainbows. Swapping out specific chemical building blocks in fluorescent molecules called rhodamines can generate nearly any color scientists desire — ROYGBIV and beyond, researchers report Sept. 4 in the journal Nature Methods. The work offers scientists a way to adjust the properties of existing dyes deliberately, making them bolder, brighter, and more cell-permeable too. More


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Boyden Global Executive Search
US – Mid-Atlantic Region

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Recursion Pharmaceuticals
US – UT – Salt Lake City

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Center for Social Neural Networks: Young Lab East
Japan – Tsukuba

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