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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit September 09, 2015

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Register NOW for SLAS2016 and SAVE!
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Registrations for SLAS2016, Jan. 23-27, San Diego, are now being accepted! SLAS members who register before Oct. 30 enjoy the deepest discounts available. Special rates are offered to academic and government participants; and students can register for just $75!

SLAS2016 will present 130+ podium presentations within 7 educational tracks, 19 short courses, more than 400 poster presentations, two keynote speakers, 300+ exhibitors and more.
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Deadline Today! 2016 SLAS Americas Council Call for Candidates
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"The Council is exciting. Its goal is to research more region-specific content and determine what drives the interests and concerns of the region,” says Hansjoerg Haas, current chair of the SLAS Americas Council. Want to become involved? Submit your name and required materials today, Sept. 9.

Nominations must include a short statement of your reasons for seeking election and an affidavit acknowledging your eligibility to serve. SLAS will select a minimum of four candidates, and all full dues-paying members of SLAS in the Americas will be invited to vote in the final election. The two candidates who earn the most votes will serve as Council members for three-year terms beginning January 2016.
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SLAS ELN Reports: Gene Editing Technology with CRISPR-Cas9 — What Life Sciences Researchers Need to Know
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"Simply put, CRISPR has the potential to transform our ability to do biomedical research," says Samuel Hasson, principal investigator, Pfizer Neuroscience. "It extends the reach of what we can achieve with genetic manipulation, particularly in mammalian systems."

He and John Doench, research scientist in the Broad Institute's RNAi Platform, discuss CRISPR-Cas9 system strengths, impact and challenges in the latest feature article in the SLAS Electronic Laboratory Neighborhood e-zine. “It’s amazing to be part of another tectonic shift in our toolbox for both in vitro and in vivo work,” Hasson adds.

He and Doench also bring their enthusiasm and expertise to the SLAS2016 Short Course, Gene Editing for Drug Discovery Jan. 23. Doench also is presenting an SLAS Webinar on Sept. 30 – Introduction to Gene Editing for Drug Discovery: Pooled Genetic Screens. Live and on-demand access to SLAS Webinars is always free to dues-paid SLAS members.
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JBS Open Access: Neuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets — Promise and Pitfalls
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NEW and FREE at JBS Online — this review article explores what a range of human genetic disorders have uncovered about the role of specific K+ channel subunits, the potential of activators and inhibitors of specific channel populations as a therapeutic strategy, and possible reasons for the difficulty in designing clinically relevant K+ channel modulators.

Edward S. A. Humphries and Caroline Dart from the Institute of Integrative Biology, University of Liverpool, UK, conclude, "The opportunity and need for novel, effective ion channel modulators exists but now need to be matched with innovative design and discovery." This is a SAGE Choice article, allowing all readers immediate free access to the full manuscript.
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VII Spanish Drug Discovery Network Meeting — Nov. 12-13 in Barcelona
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SLAS and the Spanish Drug Discovery Network collaborate to deliver information on the latest achievements in chemical biology, drug discovery and translational research. The meeting features poster presentations, an exhibition, networking opportunities and four roundtable sessions:
  • Innovation in Assay Development and Screening: New Cellular Models and New Technologies (Chair: I. Cornella Taracido)
  • Target Identification and Validation: Phenotypic Screening and Target Engagement (Chair: M. Hann)
  • Chemical Biology and Systems Biology in Drug Discovery and Development: Data Integration (Chair: J. Mestres) •
  • Public-Private Partnerships and Open Innovation in Action: Enabling (or Accelerating) Drug Discovery (Chair: A. Gomez)
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JALA and JBS Online Spotlight Italy
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JALA and JBS publish life sciences R&D achievements from around the world, and a new main menu feature at JALA Online and JBS Online spotlights recently published reports from SLAS authors in Italy. Learn more about Italian innovations, such as "Total Automation for the Core Laboratory: Improving the Turnaround Time Helps to Reduce the Volume of Ordered Stat Tests," "Improving Laboratory Efficiency by Automation of Pre-Analytic Processing of Thin Prep Specimens for Real Time-PCR High Risk HPV Testing" and more in JALA.

JBS features "CXCR4 Antagonists: A Screening Strategy for Identification of Functionally Selective Ligands," "Highly Multiplexed Phenotypic Imaging for Cell Proliferation Studies" and more.
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Human Embryo's First Genetic Stirrings Felt
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In a newly fertilized egg, the genome doesn't mobilize all at once. Just a few genes are activated at first, then a few more, day by day. The exact order in which our genes "light up" has been understood but dimly, but a new study has glimpsed new details. Out of roughly 23,000 human genes, 32 are switched on two days after fertilization, and by day three, there are 129 activated genes. More


NExT Chemical Biology Consortium (CBC) Renewal is Underway
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After five successful years of anticancer drug discovery activities, the National Cancer Institute (NCI) will renew the NCI Experimental Therapeutics (NExT) Program. The request for proposals has been issued to identify centers to participate in the second version of the CBC. Two teleconferences for potential bidders have been arranged — Sept. 24 and Oct. 15, 2015. More




Graphical Data Representation Methods To Assess the Quality of LC Columns
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Contrary to what could be expected for a technique whose foundations were laid in the 50s and 60s of the previous century, column and instrument technology for liquid chromatography has developed very rapidly in the past decade. To represent the impact of these advances in a quantitative and comprehensive way, a great variety of different graphical representation modes exist. The present feature article aims at providing an overview of these different plots and point out their best use. More


A Neuroscientist Maps Regions of the Brain That Respond to Weight Loss
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Anyone who has ever tried to lose 5 percent of his or her body weight and sustain it, will be interested in the work of neuroscientist and obesity researcher, Michael Morabito, Ph.D. A post-doctoral researcher in the laboratory of Berrie Center Co-Director Rudy Leibel, M.D., Dr. Morabito is mapping the regions of the brain that either respond, or fail to respond, to weight loss. More


First Metal-Organic Framework Made With Protein
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Chemists have engineered a protein so that it self-assembles with zinc ions and an organic small molecule to form the first protein-based metal-organic framework (MOF). Including proteins in MOFs could combine the biocatalytic, electron-transfer, and molecular recognition capabilities of proteins with the separation, storage, and catalysis applications of MOFs. More


Complete Monitoring of Coherent and Incoherent Spin Flip Domains in the Recombination of Charge-Separated States of Donor-Iridium Complex-Acceptor Triads
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The spin chemistry of photoinduced charge-separated (CS) states of three triads comprising one or two triarylamine donors, a cyclometalated iridium complex sensitizer and a naphthalene diimide (NDI) acceptor, was investigated by transient absorption spectroscopy in the ns−μs time regime. Strong magnetic-field effects (MFE) were observed for two triads with a phenylene bridge between iridium complex sensitizer and NDI acceptor. More


Scientists See Motor Neurons 'Walking' in Real Time
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
When you're taking a walk around the block, your body is mostly on autopilot — you don't have to consciously think about alternating which leg you step with or which muscles it takes to lift a foot and put it back down. That's thanks to a set of cells in your spinal cord that help translate messages between your brain and your motor neurons, which control muscles. Now, for the first time, researchers have created a method to watch — in real time — the activity of those motor neurons. More


Research Team Develops Quick Way to Determine Bacteria's Antibiotic Resistance
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Bacteria's ability to become resistant to antibiotics is a growing issue in health care: Resistant strains result in prolonged illnesses and higher mortality rates. One way to combat this is to determine bacteria's antibiotic resistance in a given patient, but that often takes days—and time is crucial in treatment. Arizona State University scientists have developed a technique that can sort antibiotic-resistant from "susceptible" bacteria, and it happens in a matter of minutes. More


Cost-Effective Catalyst Converts CO2 into Natural Gas
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The conversion of the greenhouse gas CO2 into natural gas is achieved using a chemical process in which CO2 is bubbled through an acid solution. The solution contains a graphite electrode — to which a small negative voltage is applied — with a cobalt-porphyrin catalyst attached to it. It was already known that this catalyst can convert CO2 into carbon monoxide and methane, but the reaction always released unwanted hydrogen. More


Career


Postdoctoral Fellow
University of Michigan
US – MI – Ann Arbor

Marketing Communications Specialist
Formulatrix
US – MA – Boston

Application Scientist (Automation Engineer)
New York Genome Center
US – NY – NY

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